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Items: 1 to 20 of 138

1.

Herpes simplex virus type 1 infection in neurons leads to production and nuclear localization of APP intracellular domain (AICD): implications for Alzheimer's disease pathogenesis.

Civitelli L, Marcocci ME, Celestino I, Piacentini R, Garaci E, Grassi C, De Chiara G, Palamara AT.

J Neurovirol. 2015 Oct;21(5):480-90. doi: 10.1007/s13365-015-0344-0. Epub 2015 Apr 30.

PMID:
25925093
2.

The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway.

Belyaev ND, Kellett KA, Beckett C, Makova NZ, Revett TJ, Nalivaeva NN, Hooper NM, Turner AJ.

J Biol Chem. 2010 Dec 31;285(53):41443-54. doi: 10.1074/jbc.M110.141390. Epub 2010 Oct 20.

3.

The Aβ-clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain.

Kerridge C, Belyaev ND, Nalivaeva NN, Turner AJ.

J Neurochem. 2014 Aug;130(3):419-31. doi: 10.1111/jnc.12680. Epub 2014 Mar 12.

4.

Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation.

Piacentini R, Li Puma DD, Ripoli C, Marcocci ME, De Chiara G, Garaci E, Palamara AT, Grassi C.

Sci Rep. 2015 Oct 21;5:15444. doi: 10.1038/srep15444.

5.

APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells.

De Chiara G, Marcocci ME, Civitelli L, Argnani R, Piacentini R, Ripoli C, Manservigi R, Grassi C, Garaci E, Palamara AT.

PLoS One. 2010 Nov 15;5(11):e13989. doi: 10.1371/journal.pone.0013989.

6.

Herpes simplex virus type 2 infection induces AD-like neurodegeneration markers in human neuroblastoma cells.

Kristen H, Santana S, Sastre I, Recuero M, Bullido MJ, Aldudo J.

Neurobiol Aging. 2015 Oct;36(10):2737-47. doi: 10.1016/j.neurobiolaging.2015.06.014. Epub 2015 Jun 18.

PMID:
26163986
7.

Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.

Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E.

J Neurosci Res. 2006 May 15;83(7):1252-61.

PMID:
16511867
8.

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M.

Prog Neurobiol. 2013 Jul-Aug;106-107:33-54. doi: 10.1016/j.pneurobio.2013.06.002. Epub 2013 Jul 1. Review.

PMID:
23827971
10.

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

Kim HS, Kim EM, Lee JP, Park CH, Kim S, Seo JH, Chang KA, Yu E, Jeong SJ, Chong YH, Suh YH.

FASEB J. 2003 Oct;17(13):1951-3. Epub 2003 Aug 15.

PMID:
12923068
11.

HSV-1 promotes Ca2+ -mediated APP phosphorylation and Aβ accumulation in rat cortical neurons.

Piacentini R, Civitelli L, Ripoli C, Marcocci ME, De Chiara G, Garaci E, Azzena GB, Palamara AT, Grassi C.

Neurobiol Aging. 2011 Dec;32(12):2323.e13-26. doi: 10.1016/j.neurobiolaging.2010.06.009. Epub 2010 Jul 31.

PMID:
20674092
12.

Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β.

Park H, Kam TI, Kim Y, Choi H, Gwon Y, Kim C, Koh JY, Jung YK.

Hum Mol Genet. 2012 Jun 15;21(12):2725-37. doi: 10.1093/hmg/dds100. Epub 2012 Mar 13.

PMID:
22419736
13.

Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice.

Ghosal K, Fan Q, Dawson HN, Pimplikar SW.

PLoS One. 2016 Jul 26;11(7):e0159435. doi: 10.1371/journal.pone.0159435. eCollection 2016.

14.
15.

Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-beta peptide in vivo.

Hong CS, Goins WF, Goss JR, Burton EA, Glorioso JC.

Gene Ther. 2006 Jul;13(14):1068-79. Epub 2006 Mar 16.

PMID:
16541122
16.
17.

Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration.

Chang KA, Kim HS, Ha TY, Ha JW, Shin KY, Jeong YH, Lee JP, Park CH, Kim S, Baik TK, Suh YH.

Mol Cell Biol. 2006 Jun;26(11):4327-38.

18.

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression.

Grimm MO, Mett J, Stahlmann CP, Grösgen S, Haupenthal VJ, Blümel T, Hundsdörfer B, Zimmer VC, Mylonas NT, Tanila H, Müller U, Grimm HS, Hartmann T.

Front Aging Neurosci. 2015 May 19;7:77. doi: 10.3389/fnagi.2015.00077. eCollection 2015.

19.

Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.

Grimm MO, Zinser EG, Grösgen S, Hundsdörfer B, Rothhaar TL, Burg VK, Kaestner L, Bayer TA, Lipp P, Müller U, Grimm HS, Hartmann T.

PLoS One. 2012;7(3):e34095. doi: 10.1371/journal.pone.0034095. Epub 2012 Mar 28.

20.

Alphabeta hinders nuclear targeting of AICD and Fe65 in primary neuronal cultures.

Henriques AG, Vieira SI, da Cruz e Silva EF, da Cruz e Silva OA.

J Mol Neurosci. 2009 Sep;39(1-2):248-55. doi: 10.1007/s12031-009-9192-9. Epub 2009 Apr 2.

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