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25891085,21482827,17055174,22561406,18031715,24793311,26883430,18289510,15930385,17150266,17416967,18222494,28559121,21259330,18590784,17116346,19357288,20931782,22613839,15896866,25640839,26068423,19046381,12558997,28093254,17531386,25858697,15194435,22705730,19077054,24164737,16714296,16882358,21243427,17007737,20506302,29705343,26032477,22278629,20636640,23088308,16038626,21129477,18289787,22419736,21683092,12419309,16277616,19071093,26266487,18041091,29141245,30474774,14535944,19591849,12933679,18512759,25543463,31403945,27087442,16978655,21978835,25446602,22994425,12125077,16497458,18322105,10830966,26271717,11162625,12605412,19362124,31698056,22186599,24183963,26118757,22855810,23816368,10526177,16538228,19087881,23711227,24055498,17980476,16181430,23838475,25827781,23581463,14769384,12401334,15028639,12504778,14720205,17965932,32592731,27511125,26887582,19895631,25575682,28138159,20071340,23493042,25654502,23537659,19926863,27034843,27498145,16354912,27372641,25521332,29200096,30031108,28848085,22982592,21876249,25011606,20816828,16175362,27709490,31203911,8356085,29257340,23783030,15982794,25331900,21633390,10344789,26635026,26010513,28069373,27108601,29704550,27213824,23244426,21359008,10526127,28358580,25678460,33186609,32816241,27036949,28137266,14643758,22921154,12975376,25811848,30452955,12540054,17804190,23618906,18686032,23807728,20136701,18385542,15475565,33456665,36221038,20540782,31482248,17897354,17879740,26846170,17336275,30512229,19574995,25577170,28411582,29345339,35358667,27086970,28271615,23583326,27112440,33131696,28060833,18354027,16234245,29596798,28882305,27647473,25964330,34751792,28400058,30158515,20606308,30155805,22796753,26285901,11083861,12917374,24349798,30082009,10825507,23919677,28130160,27277673,19741129,20826658,21289177,29608860,24960633,27616705,23144711,25645683,31424393,24013888,19038340,16014628,31561361,28445771,20473637,23755149,26655463,18175960,18619356,30718944,22487998,31895745,28383560,29468822,10405156,30497524,32739157,30562750,25270371,28112442,22751172,29665406,17402852,22983118,29227343,25096780,29721855,20971854,30910747,15659394,31006091,29416015,31640160,34469725,25667991,8742040,19158499,29845194,29891453,28302722,12358768,28797057,30981749,30824683,10996435,27318120,32377738,30040734,27142962,9224796,26805000,26346600,28647556,9770641,29682750,12425945,27543203,19520166,15494420,32627970,17032354,28441758,8858966,15750211,12972164,28126466,21047784,12467886,27152883,9114067,12686375,34414533,35993674,26711827,30402707,28634862,22160219,10617113,23922702,26651837,11483660,25137850,30796971,32278788,21222634,26385829,27230708,26940239,28372990,28550283,28655613,32667705,19554425,27546824,24101432,21435449,17452809,1461342,25343357,27350199,22610785,9084433,25776136,28787459,8592647,12128080,28251948,10215511,9840428,7478225,21441921,34374897,24997566,20233208,31912704,28107387,29298849,28844006,15055449,12372252,31792359,26586206,16906355,12074099,7696573,33139536,30213552,30395005,29886542,28130175,19995977,31432127,26629917,33182454,16641670,34616501,33067366,19688630,21289184,9736630,28815598,20969723,15325964,32144989,31715309,23244428,21858230,8553387,31010378,18077683,27926980,26143616,11462768,30773488,11208902,9282919,15180313,9089703,23054638,28840430,19377823,8627310,29499310,17569662,32707070,27449758,35430389,12832844,20842535,12544832,36898255,22720745,23508964,17571303,18718455,14664910,12895653,26940997,19657019,22333440,24126961,11767124,18368144,20964623,30995880,28790888,22717581,18710920,24083988,12697278,14615799,8276179,23333589,14604781,25702415,10774752,14572470,28805483,30807795,32170713,8512209,15020222,28319750,7616252,27589517,24128662,30301140,11689174,29878234,20490276,7777136,21983748,14964686,20714114,19562525,12498789,1461345,14507468,28882304,33001416,17360912,27034735,28763058,22536436,26599052,27879670,27883937,23400779,18672021,26224867,21443524,8699533,33971235,28552936,19291393,29234273,24861936,35272285,8476058,7723935,27345730,7504801,29385627,1783006,23412472,31278888,22006312,7600254,24917042,19006085,17761669,36089238,27301640,20838929,26653655,33838288,32677644,30149198,7554434,33156613,17915029,33893293,10192215,18474854,19617626,24788226,11274743,24363090,31229689,12400154,27390005,12214106,22354809,18680453,29238386,15532542,32536837,35995336,22930402,37086756,22666290,27975260,8995328,28828727,8856709,28112201,8832632,21369758,32427805,37030595,12214112,25368633,30626051,35642311,26507296,29441243,19194485,27865555,34417015,27986274,30527499,30854229,26807101,33907025[uid]

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Atorvastatin prevents Aβ oligomer-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting Tau cleavage.

Sui HJ, Zhang LL, Liu Z, Jin Y. Sui HJ, et al. Acta Pharmacol Sin. 2015 May;36(5):553-64. doi: 10.1038/aps.2014.161. Epub 2015 Apr 20. Acta Pharmacol Sin. 2015. PMID: 25891085 Free PMC article.

Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation.

Reifert J, Hartung-Cranston D, Feinstein SC. Reifert J, et al. J Biol Chem. 2011 Jun 10;286(23):20797-811. doi: 10.1074/jbc.M111.234674. Epub 2011 Apr 11. J Biol Chem. 2011. PMID: 21482827 Free PMC article.

Caspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons.

Park SY, Tournell C, Sinjoanu RC, Ferreira A. Park SY, et al. Neuroscience. 2007 Jan 5;144(1):119-27. doi: 10.1016/j.neuroscience.2006.09.012. Epub 2006 Oct 19. Neuroscience. 2007. PMID: 17055174 Free PMC article.

The protective effects of tanshinone IIA on neurotoxicity induced by β-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons.

Shi LL, Yang WN, Chen XL, Zhang JS, Yang PB, Hu XD, Han H, Qian YH, Liu Y. Shi LL, et al. Neurochem Int. 2012 Jul;61(2):227-35. doi: 10.1016/j.neuint.2012.04.019. Epub 2012 Apr 25. Neurochem Int. 2012. PMID: 22561406

Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3.

Koh SH, Noh MY, Kim SH. Koh SH, et al. Brain Res. 2008 Jan 10;1188:254-62. doi: 10.1016/j.brainres.2007.10.064. Epub 2007 Nov 1. Brain Res. 2008. PMID: 18031715

Atorvastatin prevents amyloid-β peptide oligomer-induced synaptotoxicity and memory dysfunction in rats through a p38 MAPK-dependent pathway.

Zhang LL, Sui HJ, Liang B, Wang HM, Qu WH, Yu SX, Jin Y. Zhang LL, et al. Acta Pharmacol Sin. 2014 Jun;35(6):716-26. doi: 10.1038/aps.2013.203. Epub 2014 May 5. Acta Pharmacol Sin. 2014. PMID: 24793311 Free PMC article.

Atorvastatin ameliorates cognitive impairment, Aβ1-42 production and Tau hyperphosphorylation in APP/PS1 transgenic mice.

Zhou D, Liu H, Li C, Wang F, Shi Y, Liu L, Zhao X, Liu A, Zhang J, Wang C, Chen Z. Zhou D, et al. Metab Brain Dis. 2016 Jun;31(3):693-703. doi: 10.1007/s11011-016-9803-4. Epub 2016 Feb 16. Metab Brain Dis. 2016. PMID: 26883430

Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons.

Chen X, Huang T, Zhang J, Song J, Chen L, Zhu Y. Chen X, et al. Brain Res. 2008 Mar 20;1200:99-106. doi: 10.1016/j.brainres.2007.12.029. Epub 2008 Mar 4. Brain Res. 2008. PMID: 18289510

The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

Park SY, Ferreira A. Park SY, et al. J Neurosci. 2005 Jun 1;25(22):5365-75. doi: 10.1523/JNEUROSCI.1125-05.2005. J Neurosci. 2005. PMID: 15930385 Free PMC article.

Neuroprotective effect of TNFalpha against the beta-amyloid neurotoxicity mediated by CDK5 kinase.

Orellana DI, Quintanilla RA, Maccioni RB. Orellana DI, et al. Biochim Biophys Acta. 2007 Feb;1773(2):254-63. doi: 10.1016/j.bbamcr.2006.10.010. Epub 2006 Oct 21. Biochim Biophys Acta. 2007. PMID: 17150266 Free article.

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