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Items: 1 to 20 of 94

1.

The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2.

Thomas JB, Giddings AM, Olepu S, Wiethe RW, Warner KR, Sarret P, Longpre JM, Runyon SP, Gilmour BP.

Bioorg Med Chem Lett. 2015;25(10):2060-4. doi: 10.1016/j.bmcl.2015.03.083. Epub 2015 Apr 3.

2.

Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.

Thomas JB, Giddings AM, Olepu S, Wiethe RW, Harris DL, Narayanan S, Warner KR, Sarret P, Longpre JM, Runyon SP, Gilmour BP.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):292-6. doi: 10.1016/j.bmcl.2014.11.047. Epub 2014 Nov 24.

3.

Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2.

Thomas JB, Vivancos M, Giddings AM, Wiethe RW, Warner KR, Murza A, Besserer-Offroy É, Longpré JM, Runyon SP, Decker AM, Gilmour BP, Sarret P.

ACS Chem Neurosci. 2016 Sep 21;7(9):1225-31. doi: 10.1021/acschemneuro.6b00097. Epub 2016 Jul 13.

PMID:
27359371
4.

Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.

Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP.

J Med Chem. 2014 Sep 11;57(17):7472-7. doi: 10.1021/jm500857r. Epub 2014 Aug 26.

5.

Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.

Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP.

J Med Chem. 2014 Jun 26;57(12):5318-32. doi: 10.1021/jm5003843. Epub 2014 Jun 5.

6.

Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells.

Sarret P, Gendron L, Kilian P, Nguyen HM, Gallo-Payet N, Payet MD, Beaudet A.

J Biol Chem. 2002 Sep 27;277(39):36233-43. Epub 2002 Jun 25.

7.

Impact of the proline residue on ligand binding of neurotensin receptor 2 (NTS2)-selective peptide-peptoid hybrids.

Held C, Hübner H, Kling R, Nagel YA, Wennemers H, Gmeiner P.

ChemMedChem. 2013 May;8(5):772-8. doi: 10.1002/cmdc.201300054. Epub 2013 Mar 26.

PMID:
23532897
8.

The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay.

Thomas JB, Navarro H, Warner KR, Gilmour B.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1438-41. doi: 10.1016/j.bmcl.2009.01.024. Epub 2009 Jan 15.

9.

NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain.

Smith KE, Boules M, Williams K, Richelson E.

Behav Brain Res. 2012 Jun 15;232(1):93-7. doi: 10.1016/j.bbr.2012.03.044. Epub 2012 Apr 5.

PMID:
22504145
10.

Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system.

Perron A, Sarret P, Gendron L, Stroh T, Beaudet A.

J Biol Chem. 2005 Mar 18;280(11):10219-27. Epub 2005 Jan 6.

11.

Characterization of neurotensin receptors.

Kitabgi P, Pélaprat D.

Curr Protoc Pharmacol. 2004 May;Chapter 1:Unit 1.29. doi: 10.1002/0471141755.ph0129s24.

PMID:
22294115
12.

Development of a metabolically stable neurotensin receptor 2 (NTS2) ligand.

Held C, Plomer M, Hübner H, Meltretter J, Pischetsrieder M, Gmeiner P.

ChemMedChem. 2013 Jan;8(1):75-81. doi: 10.1002/cmdc.201200376. Epub 2012 Oct 24.

PMID:
23097347
13.

Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues.

Fanelli R, Floquet N, Besserer-Offroy É, Delort B, Vivancos M, Longpré JM, Renault P, Martinez J, Sarret P, Cavelier F.

J Med Chem. 2017 Apr 27;60(8):3303-3313. doi: 10.1021/acs.jmedchem.6b01848. Epub 2017 Apr 10.

PMID:
28368584
14.

The Administration of Levocabastine, a NTS2 Receptor Antagonist, Modifies Na(+), K(+)-ATPase Properties.

Gutnisky A, López Ordieres MG, Rodríguez de Lores Arnaiz G.

Neurochem Res. 2016 Jun;41(6):1274-80. doi: 10.1007/s11064-015-1823-7. Epub 2016 Jan 7.

PMID:
26738992
15.

Neurotensin NTS1 and NTS2 receptor agonists produce anxiolytic-like effects in the 22-kHz ultrasonic vocalization model in rats.

Steele FF 3rd, Whitehouse SC, Aday JS, Prus AJ.

Brain Res. 2017 Mar 1;1658:31-35. doi: 10.1016/j.brainres.2017.01.012. Epub 2017 Jan 12.

PMID:
28089664
16.

Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2.

Gendron L, Perron A, Payet MD, Gallo-Payet N, Sarret P, Beaudet A.

Mol Pharmacol. 2004 Dec;66(6):1421-30. Epub 2004 Sep 10.

PMID:
15361549
17.

Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity.

Roussy G, Dansereau MA, Baudisson S, Ezzoubaa F, Belleville K, Beaudet N, Martinez J, Richelson E, Sarret P.

Mol Pain. 2009 Jul 6;5:38. doi: 10.1186/1744-8069-5-38.

18.

Synthesis and binding characteristics of [(3)H]neuromedin N, a NTS2 receptor ligand.

Tóth F, Mallareddy JR, Tourwé D, Lipkowski AW, Bujalska-Zadrozny M, Benyhe S, Ballet S, Tóth G, Kleczkowska P.

Neuropeptides. 2016 Jun;57:15-20. doi: 10.1016/j.npep.2015.12.004. Epub 2015 Dec 8.

PMID:
26707235
19.

Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice.

Bredeloux P, Costentin J, Dubuc I.

Behav Brain Res. 2006 Dec 15;175(2):399-407. Epub 2006 Oct 30.

PMID:
17074405
20.

Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor.

Da Costa G, Bondon A, Coutant J, Curmi P, Monti JP.

J Biomol Struct Dyn. 2013 Dec;31(12):1381-92. doi: 10.1080/07391102.2012.736776. Epub 2012 Nov 12. Erratum in: J Biomol Struct Dyn. 2014;32(1):170.

PMID:
23140271

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