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Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141.

Hsu JL, van den Boomen DJ, Tomasec P, Weekes MP, Antrobus R, Stanton RJ, Ruckova E, Sugrue D, Wilkie GS, Davison AJ, Wilkinson GW, Lehner PJ.

PLoS Pathog. 2015 Apr 14;11(4):e1004811. doi: 10.1371/journal.ppat.1004811. eCollection 2015 Apr.


Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.

van den Boomen DJ, Lehner PJ.

Mol Immunol. 2015 Dec;68(2 Pt A):106-11. doi: 10.1016/j.molimm.2015.07.005. Epub 2015 Jul 22. Review.


Inhibition of the MHC class II antigen presentation pathway by human cytomegalovirus.

Johnson DC, Hegde NR.

Curr Top Microbiol Immunol. 2002;269:101-15. Review.


Rhesus cytomegalovirus contains functional homologues of US2, US3, US6, and US11.

Pande NT, Powers C, Ahn K, Früh K.

J Virol. 2005 May;79(9):5786-98.


Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.

Barel MT, Ressing M, Pizzato N, van Leeuwen D, Le Bouteiller P, Lenfant F, Wiertz EJ.

J Immunol. 2003 Dec 15;171(12):6757-65.


TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein.

Oresic K, Ng CL, Tortorella D.

J Biol Chem. 2009 Feb 27;284(9):5905-14. doi: 10.1074/jbc.M807568200. Epub 2009 Jan 2.


Human cytomegalovirus-encoded immune modulators partner to downregulate major histocompatibility complex class I molecules.

Noriega VM, Tortorella D.

J Virol. 2009 Feb;83(3):1359-67. doi: 10.1128/JVI.01324-08. Epub 2008 Nov 12.


Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation.

Barel MT, Hassink GC, van Voorden S, Wiertz EJ.

Mol Immunol. 2006 Mar;43(8):1258-66. Epub 2005 Aug 10.


Human cytomegalovirus (HCMV) US2 protein interacts with human CD1d (hCD1d) and down-regulates invariant NKT (iNKT) cell activity.

Han J, Rho SB, Lee JY, Bae J, Park SH, Lee SJ, Lee SY, Ahn C, Kim JY, Chun T.

Mol Cells. 2013 Nov;36(5):455-64. doi: 10.1007/s10059-013-0221-8. Epub 2013 Nov 8.


Binding of human cytomegalovirus US2 to major histocompatibility complex class I and II proteins is not sufficient for their degradation.

Chevalier MS, Daniels GM, Johnson DC.

J Virol. 2002 Aug;76(16):8265-75. Erratum in: J Virol 2002 Dec;76(24):13126.


The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation.

Park B, Spooner E, Houser BL, Strominger JL, Ploegh HL.

J Exp Med. 2010 Aug 30;207(9):2033-41. doi: 10.1084/jem.20091793. Epub 2010 Aug 16.


Human CD1d molecules are resistant to human cytomegalovirus US2- and US11-mediated degradation.

Cho S, Jun Y.

Biochem Biophys Res Commun. 2011 Oct 7;413(4):616-22. doi: 10.1016/j.bbrc.2011.09.013. Epub 2011 Sep 6.


Human cytomegalovirus US3 modulates destruction of MHC class I molecules.

Noriega VM, Hesse J, Gardner TJ, Besold K, Plachter B, Tortorella D.

Mol Immunol. 2012 Jun;51(2):245-53. doi: 10.1016/j.molimm.2012.03.024. Epub 2012 Apr 10.


The role of BiP in endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain induced by cytomegalovirus proteins.

Hegde NR, Chevalier MS, Wisner TW, Denton MC, Shire K, Frappier L, Johnson DC.

J Biol Chem. 2006 Jul 28;281(30):20910-9. Epub 2006 May 25.


Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.

Rehm A, Engelsberg A, Tortorella D, Körner IJ, Lehmann I, Ploegh HL, Höpken UE.

J Virol. 2002 May;76(10):5043-50.

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