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Items: 1 to 20 of 98

1.

Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction.

Igloi Z, Kazlauskas A, Saksela K, Macdonald A, Mankouri J, Harris M.

J Gen Virol. 2015 Aug;96(8):2133-44. doi: 10.1099/vir.0.000145. Epub 2015 Apr 13.

2.

The hepatitis C virus non-structural protein NS5A alters the trafficking profile of the epidermal growth factor receptor.

Mankouri J, Griffin S, Harris M.

Traffic. 2008 Sep;9(9):1497-509. doi: 10.1111/j.1600-0854.2008.00779.x. Epub 2008 Jun 9.

3.
4.

A single-amino-acid mutation in hepatitis C virus NS5A disrupts physical and functional interaction with the transcription factor HNF-1α.

Matsui C, Rosalyn Sianipar I, Minami N, Deng L, Hotta H, Shoji I.

J Gen Virol. 2015 Aug;96(8):2200-5. doi: 10.1099/vir.0.000179. Epub 2015 May 8.

PMID:
25957097
5.

The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.

Macdonald A, Crowder K, Street A, McCormick C, Harris M.

J Gen Virol. 2004 Mar;85(Pt 3):721-9.

PMID:
14993658
6.

Hepatitis C Virus NS5A Protein Promotes the Lysosomal Degradation of Hepatocyte Nuclear Factor 1α via Chaperone-Mediated Autophagy.

Matsui C, Deng L, Minami N, Abe T, Koike K, Shoji I.

J Virol. 2018 Jun 13;92(13). pii: e00639-18. doi: 10.1128/JVI.00639-18. Print 2018 Jul 1.

7.

Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.

Amako Y, Igloi Z, Mankouri J, Kazlauskas A, Saksela K, Dallas M, Peers C, Harris M.

J Biol Chem. 2013 Aug 23;288(34):24753-63. doi: 10.1074/jbc.M113.491985. Epub 2013 Jul 15.

8.

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.

Macdonald A, Mazaleyrat S, McCormick C, Street A, Burgoyne NJ, Jackson RM, Cazeaux V, Shelton H, Saksela K, Harris M.

J Gen Virol. 2005 Apr;86(Pt 4):1035-44.

PMID:
15784897
9.

The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.

Nanda SK, Herion D, Liang TJ.

Gastroenterology. 2006 Mar;130(3):794-809. Erratum in: Gastroenterology. 2006 Aug;131(2):687.

PMID:
16530520
10.

Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation.

George A, Panda S, Kudmulwar D, Chhatbar SP, Nayak SC, Krishnan HH.

J Biol Chem. 2012 Feb 10;287(7):5042-58. doi: 10.1074/jbc.M111.308916. Epub 2011 Dec 19.

11.

Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.

He Y, Nakao H, Tan SL, Polyak SJ, Neddermann P, Vijaysri S, Jacobs BL, Katze MG.

J Virol. 2002 Sep;76(18):9207-17.

12.

A conserved proline between domains II and III of hepatitis C virus NS5A influences both RNA replication and virus assembly.

Hughes M, Gretton S, Shelton H, Brown DD, McCormick CJ, Angus AG, Patel AH, Griffin S, Harris M.

J Virol. 2009 Oct;83(20):10788-96. doi: 10.1128/JVI.02406-08. Epub 2009 Aug 5.

13.

HCV NS5A co-operates with PKR in modulating HCV IRES-dependent translation.

Karamichali E, Foka P, Tsitoura E, Kalliampakou K, Kazazi D, Karayiannis P, Georgopoulou U, Mavromara P.

Infect Genet Evol. 2014 Aug;26:113-22. doi: 10.1016/j.meegid.2014.04.015. Epub 2014 May 9.

PMID:
24815730
14.

Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap.

Ngure M, Issur M, Shkriabai N, Liu HW, Cosa G, Kvaratskhelia M, Götte M.

ACS Infect Dis. 2016 Nov 11;2(11):839-851. Epub 2016 Oct 5.

PMID:
27676132
15.

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade.

Street A, Macdonald A, Crowder K, Harris M.

J Biol Chem. 2004 Mar 26;279(13):12232-41. Epub 2004 Jan 5.

16.

Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion.

Milward A, Mankouri J, Harris M.

J Gen Virol. 2010 Feb;91(Pt 2):373-81. doi: 10.1099/vir.0.015305-0. Epub 2009 Oct 21.

PMID:
19846673
17.

The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein.

Martin-Garcia JM, Luque I, Ruiz-Sanz J, Camara-Artigas A.

Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):1030-40. doi: 10.1107/S0907444912019798. Epub 2012 Jul 17.

PMID:
22868769
19.

Structure of the c-Src-SH3 domain in complex with a proline-rich motif of NS5A protein from the hepatitis C virus.

Bacarizo J, Martínez-Rodríguez S, Cámara-Artigas A.

J Struct Biol. 2015 Jan;189(1):67-72. doi: 10.1016/j.jsb.2014.11.004. Epub 2014 Nov 25.

PMID:
25447263
20.

Transient structure and SH3 interaction sites in an intrinsically disordered fragment of the hepatitis C virus protein NS5A.

Feuerstein S, Solyom Z, Aladag A, Favier A, Schwarten M, Hoffmann S, Willbold D, Brutscher B.

J Mol Biol. 2012 Jul 20;420(4-5):310-23. doi: 10.1016/j.jmb.2012.04.023. Epub 2012 Apr 26.

PMID:
22543239

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