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Items: 1 to 20 of 83

1.

Probing residues in the pore-forming (M2) domain of the Cys-loop receptor homologue GLIC reveals some unusual features.

Alqazzaz MA, Lummis SC.

Mol Membr Biol. 2015;32(1):26-31. doi: 10.3109/09687688.2015.1023377. Epub 2015 Apr 13.

PMID:
25865129
2.

Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function.

Thompson AJ, Alqazzaz M, Price KL, Weston DA, Lummis SC.

Biochemistry. 2014 Oct 7;53(39):6183-8. doi: 10.1021/bi5008035. Epub 2014 Sep 19.

3.

Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors.

Rienzo M, Rocchi AR, Threatt SD, Dougherty DA, Lummis SC.

J Biol Chem. 2016 Mar 18;291(12):6272-80. doi: 10.1074/jbc.M115.694372. Epub 2015 Dec 14.

4.

Cys-loop receptor channel blockers also block GLIC.

Alqazzaz M, Thompson AJ, Price KL, Breitinger HG, Lummis SC.

Biophys J. 2011 Dec 21;101(12):2912-8. doi: 10.1016/j.bpj.2011.10.055. Epub 2011 Dec 20.

5.

The Proton Responsiveness in the Extracellular Domain of GLIC Differs in the Presence of the ELIC Transmembrane Domain.

Alqazzaz MA, Price KL, Lummis SCR.

Biochemistry. 2017 Apr 18;56(15):2134-2138. doi: 10.1021/acs.biochem.6b00900. Epub 2017 Apr 6.

PMID:
28383883
6.
7.

Crotonic Acid Blocks the Gloeobacter Ligand-Gated Ion Channel (GLIC) via the Extracellular Domain.

Alqazzaz MA, Price KL, Lummis SCR.

Biochemistry. 2016 Oct 25;55(42):5947-5951. doi: 10.1021/acs.biochem.6b00531. Epub 2016 Oct 14.

PMID:
27739668
8.

Structural insights into Cys-loop receptor function and ligand recognition.

Nys M, Kesters D, Ulens C.

Biochem Pharmacol. 2013 Oct 15;86(8):1042-53. doi: 10.1016/j.bcp.2013.07.001. Epub 2013 Jul 10. Review.

PMID:
23850718
9.

Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine.

Nys M, Wijckmans E, Farinha A, Yoluk Ö, Andersson M, Brams M, Spurny R, Peigneur S, Tytgat J, Lindahl E, Ulens C.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6696-E6703. Epub 2016 Oct 10.

10.

Unravelling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR.

Chasapis CT, Argyriou AI, Corringer PJ, Bentrop D, Spyroulias GA.

Biochemistry. 2011 Nov 15;50(45):9681-3. doi: 10.1021/bi201223u. Epub 2011 Oct 20.

PMID:
22007668
11.

Characterization of cys-loop receptor genes involved in inhibitory amine neurotransmission in parasitic and free living nematodes.

Beech RN, Callanan MK, Rao VT, Dawe GB, Forrester SG.

Parasitol Int. 2013 Dec;62(6):599-605. doi: 10.1016/j.parint.2013.03.010. Epub 2013 Apr 16.

PMID:
23602737
12.

Structural titration of receptor ion channel GLIC gating by HS-AFM.

Ruan Y, Kao K, Lefebvre S, Marchesi A, Corringer PJ, Hite RK, Scheuring S.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10333-10338. doi: 10.1073/pnas.1805621115. Epub 2018 Sep 4.

13.

Probing Proline Residues in the Prokaryotic Ligand-Gated Ion Channel, ELIC.

Mosesso R, Dougherty DA, Lummis SCR.

Biochemistry. 2018 Jul 10;57(27):4036-4043. doi: 10.1021/acs.biochem.8b00379. Epub 2018 Jun 21.

PMID:
29927250
14.

Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility.

Parikh RB, Bali M, Akabas MH.

J Biol Chem. 2011 Apr 22;286(16):14098-109. doi: 10.1074/jbc.M111.221895. Epub 2011 Mar 1.

15.

Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions.

Dellisanti CD, Ghosh B, Hanson SM, Raspanti JM, Grant VA, Diarra GM, Schuh AM, Satyshur K, Klug CS, Czajkowski C.

PLoS Biol. 2013 Nov;11(11):e1001714. doi: 10.1371/journal.pbio.1001714. Epub 2013 Nov 19.

16.

A locally closed conformation of a bacterial pentameric proton-gated ion channel.

Prevost MS, Sauguet L, Nury H, Van Renterghem C, Huon C, Poitevin F, Baaden M, Delarue M, Corringer PJ.

Nat Struct Mol Biol. 2012 May 13;19(6):642-9. doi: 10.1038/nsmb.2307.

PMID:
22580559
17.

Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.

Hu H, Ataka K, Menny A, Fourati Z, Sauguet L, Corringer PJ, Koehl P, Heberle J, Delarue M.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12172-E12181. doi: 10.1073/pnas.1813378116. Epub 2018 Dec 12.

PMID:
30541892
18.

An internally modulated, thermostable, pH-sensitive Cys loop receptor from the hydrothermal vent worm Alvinella pompejana.

Juneja P, Horlacher R, Bertrand D, Krause R, Marger F, Welte W.

J Biol Chem. 2014 May 23;289(21):15130-40. doi: 10.1074/jbc.M113.525576. Epub 2014 Apr 9.

19.

Molecular dissection of Cl--selective Cys-loop receptor points to components that are dispensable or essential for channel activity.

Bar-Lev DD, Degani-Katzav N, Perelman A, Paas Y.

J Biol Chem. 2011 Dec 23;286(51):43830-41. doi: 10.1074/jbc.M111.282715. Epub 2011 Oct 10.

20.

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.

Murail S, Howard RJ, Broemstrup T, Bertaccini EJ, Harris RA, Trudell JR, Lindahl E.

PLoS Comput Biol. 2012;8(10):e1002710. doi: 10.1371/journal.pcbi.1002710. Epub 2012 Oct 4.

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