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Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells.

Nguyen TT, Quan X, Hwang KH, Xu S, Das R, Choi SK, Wiederkehr A, Wollheim CB, Cha SK, Park KS.

Am J Physiol Endocrinol Metab. 2015 Jun 1;308(11):E933-41. doi: 10.1152/ajpendo.00009.2015. Epub 2015 Apr 7.


Intracellular alkalinization by phosphate uptake via type III sodium-phosphate cotransporter participates in high-phosphate-induced mitochondrial oxidative stress and defective insulin secretion.

Nguyen TT, Quan X, Xu S, Das R, Cha SK, Kong ID, Shong M, Wollheim CB, Park KS.

FASEB J. 2016 Dec;30(12):3979-3988. Epub 2016 Aug 26.


Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.

Quan X, Nguyen TT, Choi SK, Xu S, Das R, Cha SK, Kim N, Han J, Wiederkehr A, Wollheim CB, Park KS.

J Biol Chem. 2015 Feb 13;290(7):4086-96. doi: 10.1074/jbc.M114.632547. Epub 2014 Dec 29.


Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non-stimulating glucose concentration.

Roma LP, Pascal SM, Duprez J, Jonas JC.

Diabetologia. 2012 Aug;55(8):2226-37. doi: 10.1007/s00125-012-2581-6. Epub 2012 May 29.


Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets.

Liu L, Liu J, Gao Y, Yu X, Xu G, Huang Y.

Br J Pharmacol. 2014 Jul;171(13):3246-54. doi: 10.1111/bph.12666.


Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity.

Lim S, Rashid MA, Jang M, Kim Y, Won H, Lee J, Woo JT, Kim YS, Murphy MP, Ali L, Ha J, Kim SS.

Cell Physiol Biochem. 2011;28(5):873-86. doi: 10.1159/000335802. Epub 2011 Dec 15.


Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: An effect attenuated by phycocyanin.

Li XL, Chen T, Wong YS, Xu G, Fan RR, Zhao HL, Chan JC.

Int J Biochem Cell Biol. 2011 Apr;43(4):525-34. doi: 10.1016/j.biocel.2010.12.008. Epub 2010 Dec 14.


Mitochondrial phosphate transport during nutrient stimulation of INS-1E insulinoma cells.

Quan X, Das R, Xu S, Cline GW, Wiederkehr A, Wollheim CB, Park KS.

Mol Cell Endocrinol. 2013 Dec 5;381(1-2):198-209. doi: 10.1016/j.mce.2013.08.003. Epub 2013 Aug 9.


Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1.

Nishi Y, Fujimoto S, Sasaki M, Mukai E, Sato H, Sato Y, Tahara Y, Nakamura Y, Inagaki N.

Biochem J. 2011 Apr 15;435(2):421-30. doi: 10.1042/BJ20101708.


Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation.

Chang KC, Hsu CC, Liu SH, Su CC, Yen CC, Lee MJ, Chen KL, Ho TJ, Hung DZ, Wu CC, Lu TH, Su YC, Chen YW, Huang CF.

PLoS One. 2013;8(2):e54374. doi: 10.1371/journal.pone.0054374. Epub 2013 Feb 6.


Arsenic induces pancreatic β-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways.

Lu TH, Su CC, Chen YW, Yang CY, Wu CC, Hung DZ, Chen CH, Cheng PW, Liu SH, Huang CF.

Toxicol Lett. 2011 Feb 25;201(1):15-26. doi: 10.1016/j.toxlet.2010.11.019. Epub 2010 Dec 8.


Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion.

Zhang S, Carper MJ, Lei X, Cade WT, Yarasheski KE, Ramanadham S.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E925-35. doi: 10.1152/ajpendo.90445.2008. Epub 2009 Feb 10.


Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.

Li N, Brun T, Cnop M, Cunha DA, Eizirik DL, Maechler P.

J Biol Chem. 2009 Aug 28;284(35):23602-12. doi: 10.1074/jbc.M109.024323. Epub 2009 Jun 22.


Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells.

Park KS, Wiederkehr A, Kirkpatrick C, Mattenberger Y, Martinou JC, Marchetti P, Demaurex N, Wollheim CB.

J Biol Chem. 2008 Nov 28;283(48):33347-56. doi: 10.1074/jbc.M806251200. Epub 2008 Oct 2.


Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo.

Tang C, Han P, Oprescu AI, Lee SC, Gyulkhandanyan AV, Chan GN, Wheeler MB, Giacca A.

Diabetes. 2007 Nov;56(11):2722-31. Epub 2007 Aug 6.


Chlorella protects against hydrogen peroxide-induced pancreatic β-cell damage.

Lin CY, Huang PJ, Chao CY.

J Med Food. 2014 Dec;17(12):1273-80. doi: 10.1089/jmf.2013.3002.


Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes.

Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB.

Diabetes. 2010 Feb;59(2):448-59. doi: 10.2337/db09-0129. Epub 2009 Nov 10.


Respective effects of oxygen and energy substrate deprivation on beta cell viability.

Lablanche S, Cottet-Rousselle C, Argaud L, Laporte C, Lamarche F, Richard MJ, Berney T, Benhamou PY, Fontaine E.

Biochim Biophys Acta. 2015 Jun-Jul;1847(6-7):629-39. doi: 10.1016/j.bbabio.2015.04.002. Epub 2015 Apr 11.

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