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25844033,28243077,24348032,24127914,29805254,31500607,25834415,25683659,25331383,27695305,29042764,29180860,25759571,19569976,21388878,27501837,21311688,27217741,28720670,28732827,26040778,31920133,28223793,16439924,28825846,26045572,29413510,22233302,31449723,28431503,24615192,26774700,30387090,21944843,25609942,30538445,26648708,25515647,29534240,21084545,26229460,24910903,23037958,19399553,25587219,24238965,23890959,17548893,23269884,24477375,28360517,23041707,26346891,28459177,27424173,17472826,24330257,24621411,24656426,25709424,24431409,19897551,27536092,25482834,19375520,23597328,21454953,27423810,22942128,19423714,24579239,21881146,16899835,25010602,30568440,20116231,23844776,16052423,21115606,23169314,16324961,29849455,22427478,23551019,29608582,27695308,24195740,27177045,17504776,26033837,12797491,29614998,27442618,29731625,24868154,21037955,28794623,25195840,22758620,31039003,25087008,15947299,18823289,18071022,22429651,25534551,26379433,25782921,27089450,31091811,31520299,28378724,24143997,29563780,25700872,17505033,29988722,26937186,12206572,22069362,25071370,27984243,22554361,24856227,31859705,28779469,34594481,25669186,25599986,25827799,32103395,31417250,30065078,15326979,26808786,16840393,30404632,29247229,24477269,19543171,20158319,29587841,28008245,29227712,28715232,31103027,31040659,27729781,31518364,33749073,31908444,25787221,32081967,20836635,29542886,18046494,28282500,23819735,11689978,28576398,29606862,24983402,31755872,34394240,26805754,27832984,26899820,28026983,29662309,32635760,19996351,25625565,20929106,22187276,27914470,28770626,28343186,29268398,29282261,28353117,29606864,25448123,34522093,28442902,26289259,26244570,15557410,35527465,28082529,18229570,15759524,11462313,25896348,27206123,25737300,26073933,24907966,23732593,28536998,12749552,27042043,11787327,18804245,16953872,28049127,25749347,25189786,32065480,21546440,28927247,12723501,26830204,27733085,25879643,25548519,20966622,36656707,27330036,35244914,25674705,25622813,31114186,23799883,33829322,23947627,22137104,24741835,16304262,27095390,12500754,18046867,29801726,26085291,27125332,32586622,26280405,34345170,19968881,18413992,31817303,30897134,29028775,14702569,16547981,22752978,15167503,24733234,16281648,24026713,18071174,25782721,17312658,8796375,12197984,23320870,28492608,23443906,30746610,32811208,16265345,19538626,1583927,26495874,22116482,23705988,9515980,14505600,15651540,28991649,11919399,21843401,33669130,30277935,35098602,31342864,28573870,23526399,17644836,15764632,30381821,33907396,26802834,28452661,15931024,25828559,8816356,21697993,10693731,29438811,24022550,14706002,19690787,22137106,16112174,27995441,23614198,27731530,28063861,17043981,24921714,27262248,27577257,26619194,16676728,36250352,19720267,26353096,27229890,24759056,7607286,31474221,12433014,29436160,26960782,8638867,25701321,25640210,27067676,25700196,33491627,27355229,29582541,9646382,17112137,30999809,32957739,16789529,27742456,26774954,31906892,34333189,24834599,28960462,31488740,17048751,11211669,24170305,28684289,27294991,18665345,22796934,33549292,31999902,24460846,33780868,30683247,19952768,35362332,30341131,34479316,26337408,28664709,27070360,33907389,34252000,26084386,10102548,10394837,15020559,20505577,18682453,36498409,23043204,16408153,35409801,32772062,33828383,16537274,16730952,27672323,11059530,29610113,32631116,34536666,14622629,22979927,25565586,35877036,21554795,16979511,12830539,9759685,564680,14595207,31476995,32404586,32371667,23677769,28298403,2007794,25064378,24140616,31383056,25525346,26573455,31313271,19762138,30273159,11266237,22354881,12581002,31312165,37138746,35519439,29430939,25945557,3572914,14579711,8282984,36074407,27146391,18573477,27717664,37124911,23245377,20431417,34044630,24755090,31179887,23483378,22749247,8445820,22116475,8469572,34762056,28356814,16236831,21957596,27853173,36302225,32897128,28126197,17167026,24344371,24344370,16370922,29298606,23016183,22069895,10217030,27024183,17033906,23648921,34112595,19671908,7721307,34261745,34070391,15923996,23927941,32505298,6549888,24889455,4517842,21107612,26917609,24008970,10052425,22810749,36096320,16895253,26355248,623341,36198073,23799979,30354395,1608064,27201911,21808943,20976015,24415764,30869423,29248262,17910849,36828172,10985300,27201890,25644882,2729444,31700286,23347404,9585763,36815576,23684937,27320018,27117256,35105920,26066802[uid]

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Impact and factors associated with nighttime and early morning symptoms among patients with chronic obstructive pulmonary disease.

Stephenson JJ, Cai Q, Mocarski M, Tan H, Doshi JA, Sullivan SD. Stephenson JJ, et al. Int J Chron Obstruct Pulmon Dis. 2015 Mar 17;10:577-86. doi: 10.2147/COPD.S76157. eCollection 2015. Int J Chron Obstruct Pulmon Dis. 2015. PMID: 25844033 Free PMC article.

A cross-sectional survey of night-time symptoms and impact of sleep disturbance on symptoms and health status in patients with COPD.

Ding B, Small M, Bergström G, Holmgren U. Ding B, et al. Int J Chron Obstruct Pulmon Dis. 2017 Feb 13;12:589-599. doi: 10.2147/COPD.S122485. eCollection 2017. Int J Chron Obstruct Pulmon Dis. 2017. PMID: 28243077 Free PMC article.

Impact of night-time symptoms in COPD: a real-world study in five European countries.

Price D, Small M, Milligan G, Higgins V, Gil EG, Estruch J. Price D, et al. Int J Chron Obstruct Pulmon Dis. 2013;8:595-603. doi: 10.2147/COPD.S48570. Epub 2013 Nov 27. Int J Chron Obstruct Pulmon Dis. 2013. PMID: 24348032 Free PMC article.

Real world COPD: association of morning symptoms with clinical and patient reported outcomes.

Roche N, Small M, Broomfield S, Higgins V, Pollard R. Roche N, et al. COPD. 2013 Dec;10(6):679-86. doi: 10.3109/15412555.2013.844784. Epub 2013 Oct 15. COPD. 2013. PMID: 24127914

The impacts of morning, daytime, and nighttime symptoms on disease burden in real-world patients with COPD.

Muñoz A, Small M, Wood R, Ribera A, Nuevo J. Muñoz A, et al. Int J Chron Obstruct Pulmon Dis. 2018 May 15;13:1557-1568. doi: 10.2147/COPD.S157874. eCollection 2018. Int J Chron Obstruct Pulmon Dis. 2018. PMID: 29805254 Free PMC article.

Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study.

Scichilone N, Antonelli Incalzi R, Blasi F, Schino P, Cuttitta G, Zullo A, Ori A, Canonica GW; STORICO study group. Scichilone N, et al. BMC Pulm Med. 2019 Sep 9;19(1):171. doi: 10.1186/s12890-019-0935-2. BMC Pulm Med. 2019. PMID: 31500607 Free PMC article.

Evaluation of the psychometric properties of the Nighttime Symptoms of COPD Instrument.

Mocarski M, Zaiser E, Trundell D, Make BJ, Hareendran A. Mocarski M, et al. Int J Chron Obstruct Pulmon Dis. 2015 Mar 6;10:475-87. doi: 10.2147/COPD.S75776. eCollection 2015. Int J Chron Obstruct Pulmon Dis. 2015. PMID: 25834415 Free PMC article.

Impact of sleep quality on functional capacity, peripheral muscle strength and quality of life in patients with chronic obstructive pulmonary disease.

Vardar-Yagli N, Saglam M, Savci S, Inal-Ince D, Calik-Kutukcu E, Arikan H, Coplu L. Vardar-Yagli N, et al. Expert Rev Respir Med. 2015 Apr;9(2):233-9. doi: 10.1586/17476348.2015.1009041. Epub 2015 Feb 15. Expert Rev Respir Med. 2015. PMID: 25683659

Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study.

Miravitlles M, Worth H, Soler Cataluña JJ, Price D, De Benedetto F, Roche N, Godtfredsen NS, van der Molen T, Löfdahl CG, Padullés L, Ribera A. Miravitlles M, et al. Respir Res. 2014 Oct 21;15(1):122. doi: 10.1186/s12931-014-0122-1. Respir Res. 2014. PMID: 25331383 Free PMC article.

Impact of current cough on health-related quality of life in patients with COPD.

Deslee G, Burgel PR, Escamilla R, Chanez P, Court-Fortune I, Nesme-Meyer P, Brinchault-Rabin G, Perez T, Jebrak G, Caillaud D, Paillasseur JL, Roche N. Deslee G, et al. Int J Chron Obstruct Pulmon Dis. 2016 Sep 13;11:2091-2097. doi: 10.2147/COPD.S106883. eCollection 2016. Int J Chron Obstruct Pulmon Dis. 2016. PMID: 27695305 Free PMC article.

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