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Items: 1 to 20 of 90

1.

Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.

Prasad MA, Ungerbäck J, Åhsberg J, Somasundaram R, Strid T, Larsson M, Månsson R, De Paepe A, Lilljebjörn H, Fioretos T, Hagman J, Sigvardsson M.

Blood. 2015 Jun 25;125(26):4052-9. doi: 10.1182/blood-2014-12-617282. Epub 2015 Apr 2.

2.

Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.

Ungerbäck J, Åhsberg J, Strid T, Somasundaram R, Sigvardsson M.

J Exp Med. 2015 Jun 29;212(7):1109-23. doi: 10.1084/jem.20132100. Epub 2015 Jun 8.

3.

Ebf1 in DNA repair and leukemogenesis.

Georgopoulos K.

Blood. 2015 Jun 25;125(26):3969-71. doi: 10.1182/blood-2015-05-639427.

4.

Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.

Åhsberg J, Ungerbäck J, Strid T, Welinder E, Stjernberg J, Larsson M, Qian H, Sigvardsson M.

J Biol Chem. 2013 Nov 15;288(46):33449-61. doi: 10.1074/jbc.M113.506261. Epub 2013 Sep 27.

5.

A dose-dependent role for EBF1 in repressing non-B-cell-specific genes.

Lukin K, Fields S, Guerrettaz L, Straign D, Rodriguez V, Zandi S, Månsson R, Cambier JC, Sigvardsson M, Hagman J.

Eur J Immunol. 2011 Jun;41(6):1787-93. doi: 10.1002/eji.201041137. Epub 2011 May 9.

6.

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.

Heltemes-Harris LM, Willette MJ, Ramsey LB, Qiu YH, Neeley ES, Zhang N, Thomas DA, Koeuth T, Baechler EC, Kornblau SM, Farrar MA.

J Exp Med. 2011 Jun 6;208(6):1135-49. doi: 10.1084/jem.20101947. Epub 2011 May 23.

7.

Comprehensive Proteomic Investigation of Ebf1 Heterozygosity in Pro-B Lymphocytes Utilizing Data Independent Acquisition.

Musa YR, Boller S, Puchalska M, Grosschedl R, Mittler G.

J Proteome Res. 2018 Jan 5;17(1):76-85. doi: 10.1021/acs.jproteome.7b00369. Epub 2017 Dec 11.

PMID:
29181981
8.

Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression.

Lukin K, Fields S, Lopez D, Cherrier M, Ternyak K, Ramírez J, Feeney AJ, Hagman J.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7869-74. doi: 10.1073/pnas.1003525107. Epub 2010 Apr 12.

9.

Runx1-Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1.

Seo W, Ikawa T, Kawamoto H, Taniuchi I.

J Exp Med. 2012 Jul 2;209(7):1255-62. doi: 10.1084/jem.20112745. Epub 2012 Jun 4.

10.

The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells.

Ebert A, McManus S, Tagoh H, Medvedovic J, Salvagiotto G, Novatchkova M, Tamir I, Sommer A, Jaritz M, Busslinger M.

Immunity. 2011 Feb 25;34(2):175-87. doi: 10.1016/j.immuni.2011.02.005.

11.

Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5.

Roessler S, Györy I, Imhof S, Spivakov M, Williams RR, Busslinger M, Fisher AG, Grosschedl R.

Mol Cell Biol. 2007 Jan;27(2):579-94. Epub 2006 Nov 13.

12.

The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.

Itoh-Nakadai A, Hikota R, Muto A, Kometani K, Watanabe-Matsui M, Sato Y, Kobayashi M, Nakamura A, Miura Y, Yano Y, Tashiro S, Sun J, Ikawa T, Ochiai K, Kurosaki T, Igarashi K.

Nat Immunol. 2014 Dec;15(12):1171-80. doi: 10.1038/ni.3024. Epub 2014 Oct 26.

PMID:
25344725
13.

Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma.

Bohle V, Döring C, Hansmann ML, Küppers R.

Leukemia. 2013 Mar;27(3):671-9. doi: 10.1038/leu.2012.280. Epub 2012 Oct 1.

PMID:
23174882
14.

Independent regulation of the two Pax5 alleles during B-cell development.

Nutt SL, Vambrie S, Steinlein P, Kozmik Z, Rolink A, Weith A, Busslinger M.

Nat Genet. 1999 Apr;21(4):390-5.

PMID:
10192389
15.

Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis.

Decker T, Pasca di Magliano M, McManus S, Sun Q, Bonifer C, Tagoh H, Busslinger M.

Immunity. 2009 Apr 17;30(4):508-20. doi: 10.1016/j.immuni.2009.01.012. Epub 2009 Apr 2.

16.

Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming.

Li R, Cauchy P, Ramamoorthy S, Boller S, Chavez L, Grosschedl R.

Genes Dev. 2018 Jan 15;32(2):96-111. doi: 10.1101/gad.309583.117. Epub 2018 Feb 9.

17.

Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development.

Simmons S, Knoll M, Drewell C, Wolf I, Mollenkopf HJ, Bouquet C, Melchers F.

Blood. 2012 Nov 1;120(18):3688-98. doi: 10.1182/blood-2012-03-414821. Epub 2012 Aug 27.

18.

Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin.

Treiber T, Mandel EM, Pott S, Györy I, Firner S, Liu ET, Grosschedl R.

Immunity. 2010 May 28;32(5):714-25. doi: 10.1016/j.immuni.2010.04.013. Epub 2010 May 6.

19.

EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors.

Zandi S, Mansson R, Tsapogas P, Zetterblad J, Bryder D, Sigvardsson M.

J Immunol. 2008 Sep 1;181(5):3364-72.

20.

Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.

Mansson R, Zandi S, Welinder E, Tsapogas P, Sakaguchi N, Bryder D, Sigvardsson M.

Blood. 2010 Apr 1;115(13):2601-9. doi: 10.1182/blood-2009-08-236398. Epub 2009 Dec 8.

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