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Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression.

Ramasubramanyan S, Osborn K, Al-Mohammad R, Naranjo Perez-Fernandez IB, Zuo J, Balan N, Godfrey A, Patel H, Peters G, Rowe M, Jenner RG, Sinclair AJ.

Nucleic Acids Res. 2015 Apr 20;43(7):3563-77. doi: 10.1093/nar/gkv212. Epub 2015 Mar 16.


Genome-wide analyses of Zta binding to the Epstein-Barr virus genome reveals interactions in both early and late lytic cycles and an epigenetic switch leading to an altered binding profile.

Ramasubramanyan S, Kanhere A, Osborn K, Flower K, Jenner RG, Sinclair AJ.

J Virol. 2012 Dec;86(23):12494-502. doi: 10.1128/JVI.01705-12. Epub 2012 Sep 26.


Repression of CIITA by the Epstein-Barr virus transcription factor Zta is independent of its dimerization and DNA binding.

Balan N, Osborn K, Sinclair AJ.

J Gen Virol. 2016 Mar;97(3):725-32. doi: 10.1099/jgv.0.000369. Epub 2015 Dec 11.


Dynamic chromatin environment of key lytic cycle regulatory regions of the Epstein-Barr virus genome.

Ramasubramanyan S, Osborn K, Flower K, Sinclair AJ.

J Virol. 2012 Feb;86(3):1809-19. doi: 10.1128/JVI.06334-11. Epub 2011 Nov 16.


CpG-methylation regulates a class of Epstein-Barr virus promoters.

Bergbauer M, Kalla M, Schmeinck A, Göbel C, Rothbauer U, Eck S, Benet-Pagès A, Strom TM, Hammerschmidt W.

PLoS Pathog. 2010 Sep 23;6(9):e1001114. doi: 10.1371/journal.ppat.1001114.


DNA-binding-defective mutants of the Epstein-Barr virus lytic switch activator Zta transactivate with altered specificities.

Flemington EK, Lytle JP, Cayrol C, Borras AM, Speck SH.

Mol Cell Biol. 1994 May;14(5):3041-52.


Mechanism of activation of the BNLF2a immune evasion gene of Epstein-Barr virus by Zta.

Almohammed R, Osborn K, Ramasubramanyan S, Perez-Fernandez IBN, Godfrey A, Mancini EJ, Sinclair AJ.

J Gen Virol. 2018 Jun;99(6):805-817. doi: 10.1099/jgv.0.001056. Epub 2018 Mar 26.


A redox-sensitive cysteine in Zta is required for Epstein-Barr virus lytic cycle DNA replication.

Wang P, Day L, Dheekollu J, Lieberman PM.

J Virol. 2005 Nov;79(21):13298-309.


The Epstein-Barr virus lytic cycle activator Zta interacts with methylated ZRE in the promoter of host target gene egr1.

Heather J, Flower K, Isaac S, Sinclair AJ.

J Gen Virol. 2009 Jun;90(Pt 6):1450-4. doi: 10.1099/vir.0.007922-0. Epub 2009 Mar 4.


Epstein-Barr virus lytic transactivator Zta enhances chemotactic activity through induction of interleukin-8 in nasopharyngeal carcinoma cells.

Hsu M, Wu SY, Chang SS, Su IJ, Tsai CH, Lai SJ, Shiau AL, Takada K, Chang Y.

J Virol. 2008 Apr;82(7):3679-88. doi: 10.1128/JVI.02301-07. Epub 2008 Jan 30.


Enhancement of Zta-activated lytic transcription of Epstein-Barr virus by Ku80.

Chen CC, Yang YC, Wang WH, Chen CS, Chang LK.

J Gen Virol. 2011 Mar;92(Pt 3):661-8. doi: 10.1099/vir.0.026302-0. Epub 2010 Dec 1.


Down-regulation of MHC class II expression through inhibition of CIITA transcription by lytic transactivator Zta during Epstein-Barr virus reactivation.

Li D, Qian L, Chen C, Shi M, Yu M, Hu M, Song L, Shen B, Guo N.

J Immunol. 2009 Feb 15;182(4):1799-809. doi: 10.4049/jimmunol.0802686.


Evaluation of a prediction protocol to identify potential targets of epigenetic reprogramming by the cancer associated Epstein Barr virus.

Flower K, Hellen E, Newport MJ, Jones S, Sinclair AJ.

PLoS One. 2010 Feb 26;5(2):e9443. doi: 10.1371/journal.pone.0009443.


Epigenetic control of viral life-cycle by a DNA-methylation dependent transcription factor.

Flower K, Thomas D, Heather J, Ramasubramanyan S, Jones S, Sinclair AJ.

PLoS One. 2011;6(10):e25922. doi: 10.1371/journal.pone.0025922. Epub 2011 Oct 11.

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