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CD40 ligand exhibits a direct antiviral effect on Herpes Simplex Virus type-1 infection via a PI3K-dependent, autophagy-independent mechanism.

Vlahava VM, Eliopoulos AG, Sourvinos G.

Cell Signal. 2015 Jun;27(6):1253-63. doi: 10.1016/j.cellsig.2015.03.002. Epub 2015 Mar 10.


BX-795 inhibits HSV-1 and HSV-2 replication by blocking the JNK/p38 pathways without interfering with PDK1 activity in host cells.

Su AR, Qiu M, Li YL, Xu WT, Song SW, Wang XH, Song HY, Zheng N, Wu ZW.

Acta Pharmacol Sin. 2017 Mar;38(3):402-414. doi: 10.1038/aps.2016.160. Epub 2017 Jan 23.


CD40 inhibits replication of hepatitis C virus in primary human hepatocytes by c-Jun N terminal kinase activation independent from the interferon pathway.

Rau SJ, Hildt E, Himmelsbach K, Thimme R, Wakita T, Blum HE, Fischer R.

Hepatology. 2013 Jan;57(1):23-36. doi: 10.1002/hep.25966.


Resveratrol suppresses nuclear factor-kappaB in herpes simplex virus infected cells.

Faith SA, Sweet TJ, Bailey E, Booth T, Docherty JJ.

Antiviral Res. 2006 Dec;72(3):242-51. Epub 2006 Jul 14.


Phosphoinositide 3-kinase mediates CD40 ligand-induced oxidative stress and endothelial dysfunction via Rac1 and NADPH oxidase 2.

Xia M, Li G, Ma J, Ling W.

J Thromb Haemost. 2010 Feb;8(2):397-406. doi: 10.1111/j.1538-7836.2009.03683.x. Epub 2009 Nov 6.


Herpes simplex virus type 1 entry is inhibited by the cobalt chelate complex CTC-96.

Schwartz JA, Lium EK, Silverstein SJ.

J Virol. 2001 May;75(9):4117-28.


CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis.

Mineva ND, Rothstein TL, Meyers JA, Lerner A, Sonenshein GE.

J Biol Chem. 2007 Jun 15;282(24):17475-85. Epub 2007 Apr 19.


CK2 inhibitors increase the sensitivity of HSV-1 to interferon-β.

Smith MC, Bayless AM, Goddard ET, Davido DJ.

Antiviral Res. 2011 Sep;91(3):259-66. doi: 10.1016/j.antiviral.2011.06.009. Epub 2011 Jun 22.


Phosphatidylinositol 3-kinase and NF-kappa B/Rel are at the divergence of CD40-mediated proliferation and survival pathways.

Andjelic S, Hsia C, Suzuki H, Kadowaki T, Koyasu S, Liou HC.

J Immunol. 2000 Oct 1;165(7):3860-7.


Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication.

Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Fujii N.

Virology. 2005 Jul 20;338(1):173-81.


Efficacy of an aqueous Pelargonium sidoides extract against herpesvirus.

Schnitzler P, Schneider S, Stintzing FC, Carle R, Reichling J.

Phytomedicine. 2008 Dec;15(12):1108-16. doi: 10.1016/j.phymed.2008.06.009. Epub 2008 Aug 8.


Autophagy Negatively Regulates Transmissible Gastroenteritis Virus Replication.

Guo L, Yu H, Gu W, Luo X, Li R, Zhang J, Xu Y, Yang L, Shen N, Feng L, Wang Y.

Sci Rep. 2016 Mar 31;6:23864. doi: 10.1038/srep23864.


Downregulation of cellular c-Jun N-terminal protein kinase and NF-κB activation by berberine may result in inhibition of herpes simplex virus replication.

Song S, Qiu M, Chu Y, Chen D, Wang X, Su A, Wu Z.

Antimicrob Agents Chemother. 2014 Sep;58(9):5068-78. doi: 10.1128/AAC.02427-14. Epub 2014 Jun 9.


Xenophagy in herpes simplex virus replication and pathogenesis.

Alexander DE, Leib DA.

Autophagy. 2008 Jan;4(1):101-3. Epub 2007 Oct 31.


Inhibition of clinical pathogenic herpes simplex virus 1 strains with enzymatically created siRNA pools.

Paavilainen H, Lehtinen J, Romanovskaya A, Nygårdas M, Bamford DH, Poranen MM, Hukkanen V.

J Med Virol. 2016 Dec;88(12):2196-2205. doi: 10.1002/jmv.24578. Epub 2016 May 30.


Barrier to auto integration factor becomes dephosphorylated during HSV-1 Infection and Can Act as a host defense by impairing viral DNA replication and gene expression.

Jamin A, Thunuguntla P, Wicklund A, Jones C, Wiebe MS.

PLoS One. 2014 Jun 19;9(6):e100511. doi: 10.1371/journal.pone.0100511. eCollection 2014.


Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro.

Pei Y, Chen ZP, Ju HQ, Komatsu M, Ji YH, Liu G, Guo CW, Zhang YJ, Yang CR, Wang YF, Kitazato K.

Biochem Biophys Res Commun. 2011 Feb 11;405(2):186-91. doi: 10.1016/j.bbrc.2011.01.006. Epub 2011 Jan 7.


Herpes simplex virus internalization into epithelial cells requires Na+/H+ exchangers and p21-activated kinases but neither clathrin- nor caveolin-mediated endocytosis.

Devadas D, Koithan T, Diestel R, Prank U, Sodeik B, Döhner K.

J Virol. 2014 Nov;88(22):13378-95. doi: 10.1128/JVI.03631-13. Epub 2014 Sep 10.

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