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When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.

Carré A, Louzada RA, Fortunato RS, Ameziane-El-Hassani R, Morand S, Ogryzko V, de Carvalho DP, Grasberger H, Leto TL, Dupuy C.

Antioxid Redox Signal. 2015 Sep 20;23(9):724-33. doi: 10.1089/ars.2015.6265. Epub 2015 Apr 20.


Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor.

Grasberger H, De Deken X, Miot F, Pohlenz J, Refetoff S.

Mol Endocrinol. 2007 Jun;21(6):1408-21. Epub 2007 Mar 20.


Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.

Louzada RA, Corre R, Ameziane-El-Hassani R, Hecht F, Cazarin J, Buffet C, Carvalho DP, Dupuy C.

Thyroid. 2018 Aug;28(8):1052-1062. doi: 10.1089/thy.2017.0596. Epub 2018 Jul 24.


Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.

Meitzler JL, Hinde S, Bánfi B, Nauseef WM, Ortiz de Montellano PR.

J Biol Chem. 2013 Mar 8;288(10):7147-57. doi: 10.1074/jbc.M112.414797. Epub 2013 Jan 28.


The extracellular A-loop of dual oxidases affects the specificity of reactive oxygen species release.

Ueyama T, Sakuma M, Ninoyu Y, Hamada T, Dupuy C, Geiszt M, Leto TL, Saito N.

J Biol Chem. 2015 Mar 6;290(10):6495-506. doi: 10.1074/jbc.M114.592717. Epub 2015 Jan 13.


Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2.

Raad H, Eskalli Z, Corvilain B, Miot F, De Deken X.

Free Radic Biol Med. 2013 Mar;56:216-25. doi: 10.1016/j.freeradbiomed.2012.09.003. Epub 2012 Sep 23.


Targeting of the dual oxidase 2 N-terminal region to the plasma membrane.

Morand S, Agnandji D, Noel-Hudson MS, Nicolas V, Buisson S, Macon-Lemaitre L, Gnidehou S, Kaniewski J, Ohayon R, Virion A, Dupuy C.

J Biol Chem. 2004 Jul 16;279(29):30244-51. Epub 2004 May 18.


Up-regulation and sustained activation of Stat1 are essential for interferon-gamma (IFN-gamma)-induced dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines.

Wu Y, Antony S, Juhasz A, Lu J, Ge Y, Jiang G, Roy K, Doroshow JH.

J Biol Chem. 2011 Apr 8;286(14):12245-56. doi: 10.1074/jbc.M110.191031. Epub 2011 Feb 14.


Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation.

Morand S, Ueyama T, Tsujibe S, Saito N, Korzeniowska A, Leto TL.

FASEB J. 2009 Apr;23(4):1205-18. doi: 10.1096/fj.08-120006. Epub 2008 Dec 12.


DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.

MacFie TS, Poulsom R, Parker A, Warnes G, Boitsova T, Nijhuis A, Suraweera N, Poehlmann A, Szary J, Feakins R, Jeffery R, Harper RW, Jubb AM, Lindsay JO, Silver A.

Inflamm Bowel Dis. 2014 Mar;20(3):514-24. doi: 10.1097/01.MIB.0000442012.45038.0e. Erratum in: Inflamm Bowel Dis. 2014 Apr;20(4):775.


Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody.

Wu Y, Antony S, Hewitt SM, Jiang G, Yang SX, Meitzler JL, Juhasz A, Lu J, Liu H, Doroshow JH, Roy K.

Int J Oncol. 2013 Apr;42(4):1229-38. doi: 10.3892/ijo.2013.1821. Epub 2013 Feb 11.


Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2.

Donkó Á, Morand S, Korzeniowska A, Boudreau HE, Zana M, Hunyady L, Geiszt M, Leto TL.

Free Radic Biol Med. 2014 Aug;73:190-200. doi: 10.1016/j.freeradbiomed.2014.05.006. Epub 2014 May 20.


Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.

Grasberger H, Refetoff S.

J Biol Chem. 2006 Jul 7;281(27):18269-72. Epub 2006 May 1.


A single copy of the recently identified dual oxidase maturation factor (DUOXA) 1 gene produces only mild transient hypothyroidism in a patient with a novel biallelic DUOXA2 mutation and monoallelic DUOXA1 deletion.

Hulur I, Hermanns P, Nestoris C, Heger S, Refetoff S, Pohlenz J, Grasberger H.

J Clin Endocrinol Metab. 2011 May;96(5):E841-5. doi: 10.1210/jc.2010-2321. Epub 2011 Mar 2.


Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.

Ameziane-El-Hassani R, Morand S, Boucher JL, Frapart YM, Apostolou D, Agnandji D, Gnidehou S, Ohayon R, Noël-Hudson MS, Francon J, Lalaoui K, Virion A, Dupuy C.

J Biol Chem. 2005 Aug 26;280(34):30046-54. Epub 2005 Jun 22.


Regulation of dual oxidase expression and H2O2 production by thyroglobulin.

Yoshihara A, Hara T, Kawashima A, Akama T, Tanigawa K, Wu H, Sue M, Ishido Y, Hiroi N, Ishii N, Yoshino G, Suzuki K.

Thyroid. 2012 Oct;22(10):1054-62. doi: 10.1089/thy.2012.0003. Epub 2012 Aug 8.


Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membrane.

Fortunato RS, Lima de Souza EC, Ameziane-el Hassani R, Boufraqech M, Weyemi U, Talbot M, Lagente-Chevallier O, de Carvalho DP, Bidart JM, Schlumberger M, Dupuy C.

J Clin Endocrinol Metab. 2010 Dec;95(12):5403-11. doi: 10.1210/jc.2010-1085. Epub 2010 Sep 8.


Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism.

Zamproni I, Grasberger H, Cortinovis F, Vigone MC, Chiumello G, Mora S, Onigata K, Fugazzola L, Refetoff S, Persani L, Weber G.

J Clin Endocrinol Metab. 2008 Feb;93(2):605-10. Epub 2007 Nov 27.


The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.

Hoste C, Dumont JE, Miot F, De Deken X.

Exp Cell Res. 2012 Nov 1;318(18):2353-64. doi: 10.1016/j.yexcr.2012.07.007. Epub 2012 Jul 16.


A novel missense mutation (I26M) in DUOXA2 causing congenital goiter hypothyroidism impairs NADPH oxidase activity but not protein expression.

Liu S, Liu L, Niu X, Lu D, Xia H, Yan S.

J Clin Endocrinol Metab. 2015 Apr;100(4):1225-9. doi: 10.1210/jc.2014-3964. Epub 2015 Feb 12.


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