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25703330,22090358,21447797,22442268,29320991,20699365,22668349,22964644,26802026,30809081,21985784,24489653,20179705,27154822,22261800,25029414,26272063,25199829,24947927,27226552,19372556,26799289,20130576,24746704,24121058,26245900,24675361,21674991,30300582,21447798,29348459,19276360,30563872,26678033,29059158,22892241,23614898,19843849,19010912,19474002,22797077,22392911,33113355,24071646,22441145,27699948,27999210,24371145,31048689,19637312,18676837,28640835,28002807,22430215,22696593,33795873,19018267,24011934,24300897,24848561,30466782,20926530,22205714,16854453,25297634,25361980,23095323,22583421,30154150,23058743,30104724,29760222,16140948,22871572,25644510,26404261,30115483,26725216,22270368,23085539,20664172,20942929,23580196,22773810,28797845,27391062,34759319,23153539,23006971,34830283,20664174,22260668,28674184,23454899,24163374,35272617,26676756,21411864,17353198,28167505,27911794,34737198,23667175,25002494,23752269,24612015,34337566,25624485,28423521,26820797,33318037,26343582,27686868,27655129,19401449,24642271,30429107,26140595,23934108,32139876,27936234,22402123,19492075,33294856,33355204,31668570,23580570,19881948,32245042,25155755,22511580,35139374,31536726,28270557,26028026,25524577,31577942,30353166,22351689,30294831,26090869,28775144,31182717,33589518,26898828,26028035,21277645,21289294,36856908,26369631,22140652,24747911,30482246,30021885,22342683,25753158,33821796,25182533,22752425,35091470,28982154,27437872,21388951,31266962,19029981,19087308,25697003,34304249,29440321,36056964,25435214,31362929,22983922,26582644,36321226,19966866,21451123,30262568,19351816,22628411,21148749,30007540,27437940,28174173,27423883,29129563,25889965,29970458,23547054,26299805,27793696,21738705,19490892,29196297,23390495,27576686,31439581,19965690,21898400,25908604,27669459,26999821,29395869,25150293,24568222,25414119,33242077,29896883,22065586,30709910,21813464,31243962,25847954,29907857,34192548,21196179,33203698,26384305,25813020,28280521,22082529,32605999,26832798,25975913,23604129,22043453,29288529,24948110,30988000,21200439,23489586,30194764,27764698,30065098,34688654,31262731,23637129,26418750,34470822,25152578,35806187,26350096,27301828,18268007,30977659,21441104,19608870,33989908,36493900,29510196,26065894,19274086,31043489,28554329,24931611,27340238,28819643,25695333,22323609,16505104,33896272,31213532,28282860,36197750,26880715,28551618,33672357,29947013,26575954,27979926,34301793,27072130,26876154,33901448,30605687,29488071,27940576,21169357,25341034,33793658,28969371,24969890,22383492,22064482,27733477,22193779,23658296,27713963,35787369,21209378,29346301,24525237,25955298,32873792,29679238,30577618,31042025,22341439,30482887,22826122,25167228,33073539,30475204,25946136,21336309,29180761,27893461,22613949,27922010,19789336,22087839,25981859,25023700,36533617,32492656,19520853,29170065,27805296,23288781,30605831,28286738,22393091,34450320,29915291,22535956,35766855,21910869,20046837,29432815,35288294,24913553,28783725,29454854,23403635,31316177,22833671,33414552,25584887,24095280,27841290,18725993,28178529,19098454,18948081,29084939,33279609,24496383,15668520,31596728,29431672,31040156,26500282,33060766,22653334,36319849,29524560,26438159,27159396,25466250,23820584,29307569,30201956,32719131,31186280,22451720,30978703,22515520,19177005,35039569,22886659,34919787,30664964,29983389,20972333,25034101,32877650,24497849,21531565,27155372,33203961,32385388,26284568,30282811,30045908,23161513,32163057,25339352,30171261,24416731,26373275,30833752,24469059,27925667,30149880,35149086,19490893,29551131,36451866,30206308,33208845,32156782,34725361,33461973,30426981,28512244,23092099,34433654,30785867,35059897,25073112,32069380,28320962,36920903,24632612,29336889,25543165,21835307,33198372,30166458,31744895,31602313,30275173,36534167,31389313,31439712,21076620,29438690,28148904,35325867,35276360,20718706,31740452,23459937,21364986,25599653,30311220,23419283,29258623,28202657,25643809,33784561,24996772,33340965,27936345,29930381,24954536,29101114,30509235,30424720,30857244,31133691,24606580,19190631,19805051,33500359,21903676,22671702,33675084,32194893,28079897,24211266,26807315,26885666,23746401,28562352,29050198,27510948,22227015,28580280,27461835,35398967,36682330,35262628,10597313,25303301,28118599,29156677,24928447,23246410,34685488,29748115,26423694,30194290,33925206,23814489,29316436,36418460,28210154,34645806,30167080,32609833,30400219,34121659,22130230,28207208,33976200,29970615,21829637,35513296,36138080,22615393,23599344,22318779,28730469,32405640,23535008,28199803,29374019,33328217,23566315,29444439,27803104,27389825,27587266,35582726,19745602,24435447,15343278,28086984,25833940,32375238,22829590,35831322,24444711,19366732,35585049,32191874,25023699,30186180,33309959,27822414,27941888,29295962,29518522,23907581,33007229,35883626,27422332,31208693,27984728,15876869,28077300,24479809,30381447,31247990,28207209,31698452,31057104,31040047,20427710,30764494,29199017,35858545,34347396,35014625,31935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Year	Number of Results
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686 results

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mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells.

Komatsu N, Fujita Y, Matsuda M, Aoki K. Komatsu N, et al. Oncogene. 2015 Nov 5;34(45):5607-16. doi: 10.1038/onc.2015.16. Epub 2015 Feb 23. Oncogene. 2015. PMID: 25703330 Free article.

Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways.

Yuen HF, Chan KK, Grills C, Murray JT, Platt-Higgins A, Eldin OS, O'Byrne K, Janne P, Fennell DA, Johnston PG, Rudland PS, El-Tanani M. Yuen HF, et al. Clin Cancer Res. 2012 Jan 15;18(2):380-91. doi: 10.1158/1078-0432.CCR-11-2035. Epub 2011 Nov 16. Clin Cancer Res. 2012. PMID: 22090358 Free PMC article.

Resistance to MEK inhibitors: should we co-target upstream?

Poulikakos PI, Solit DB. Poulikakos PI, et al. Sci Signal. 2011 Mar 29;4(166):pe16. doi: 10.1126/scisignal.2001948. Sci Signal. 2011. PMID: 21447797 Review.

Activation of the RAS/RAF/ERK signaling pathway contributes to resistance to sunitinib in thyroid carcinoma cell lines.

Piscazzi A, Costantino E, Maddalena F, Natalicchio MI, Gerardi AM, Antonetti R, Cignarelli M, Landriscina M. Piscazzi A, et al. J Clin Endocrinol Metab. 2012 Jun;97(6):E898-906. doi: 10.1210/jc.2011-3269. Epub 2012 Mar 22. J Clin Endocrinol Metab. 2012. PMID: 22442268

An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation.

Heard JJ, Phung I, Potes MI, Tamanoi F. Heard JJ, et al. BMC Cancer. 2018 Jan 10;18(1):69. doi: 10.1186/s12885-017-3938-5. BMC Cancer. 2018. PMID: 29320991 Free PMC article.

PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling.

Halilovic E, She QB, Ye Q, Pagliarini R, Sellers WR, Solit DB, Rosen N. Halilovic E, et al. Cancer Res. 2010 Sep 1;70(17):6804-14. doi: 10.1158/0008-5472.CAN-10-0409. Epub 2010 Aug 10. Cancer Res. 2010. PMID: 20699365 Free PMC article.

Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells.

Yuen HF, Abramczyk O, Montgomery G, Chan KK, Huang YH, Sasazuki T, Shirasawa S, Gopesh S, Chan KW, Fennell D, Janne P, El-Tanani M, Murray JT. Yuen HF, et al. Biosci Rep. 2012 Aug;32(4):413-22. doi: 10.1042/BSR20120050. Biosci Rep. 2012. PMID: 22668349 Free PMC article.

Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer.

Sunaga N, Kaira K, Imai H, Shimizu K, Nakano T, Shames DS, Girard L, Soh J, Sato M, Iwasaki Y, Ishizuka T, Gazdar AF, Minna JD, Mori M. Sunaga N, et al. Oncogene. 2013 Aug 22;32(34):4034-42. doi: 10.1038/onc.2012.402. Epub 2012 Sep 10. Oncogene. 2013. PMID: 22964644 Free PMC article.

BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells.

Goulielmaki M, Koustas E, Moysidou E, Vlassi M, Sasazuki T, Shirasawa S, Zografos G, Oikonomou E, Pintzas A. Goulielmaki M, et al. Oncotarget. 2016 Feb 23;7(8):9188-221. doi: 10.18632/oncotarget.6942. Oncotarget. 2016. PMID: 26802026 Free PMC article.

Relationships among KRAS mutation status, expression of RAS pathway signaling molecules, and clinicopathological features and prognosis of patients with colorectal cancer.

Wan XB, Wang AQ, Cao J, Dong ZC, Li N, Yang S, Sun MM, Li Z, Luo SX. Wan XB, et al. World J Gastroenterol. 2019 Feb 21;25(7):808-823. doi: 10.3748/wjg.v25.i7.808. World J Gastroenterol. 2019. PMID: 30809081 Free PMC article.

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