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Avibactam and inhibitor-resistant SHV β-lactamases.

Winkler ML, Papp-Wallace KM, Taracila MA, Bonomo RA.

Antimicrob Agents Chemother. 2015 Jul;59(7):3700-9. doi: 10.1128/AAC.04405-14. Epub 2015 Feb 17.


Variants of β-lactamase KPC-2 that are resistant to inhibition by avibactam.

Papp-Wallace KM, Winkler ML, Taracila MA, Bonomo RA.

Antimicrob Agents Chemother. 2015 Jul;59(7):3710-7. doi: 10.1128/AAC.04406-14. Epub 2015 Feb 9.


Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop.

Winkler ML, Papp-Wallace KM, Bonomo RA.

J Antimicrob Chemother. 2015 Aug;70(8):2279-86. doi: 10.1093/jac/dkv094. Epub 2015 May 8.


Reclaiming the efficacy of β-lactam-β-lactamase inhibitor combinations: avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime.

Papp-Wallace KM, Winkler ML, Gatta JA, Taracila MA, Chilakala S, Xu Y, Johnson JK, Bonomo RA.

Antimicrob Agents Chemother. 2014 Aug;58(8):4290-7. doi: 10.1128/AAC.02625-14. Epub 2014 May 12.


Efficacy of a Ceftazidime-Avibactam combination in a murine model of Septicemia caused by Enterobacteriaceae species producing ampc or extended-spectrum β-lactamases.

Levasseur P, Girard AM, Lavallade L, Miossec C, Pace J, Coleman K.

Antimicrob Agents Chemother. 2014 Nov;58(11):6490-5. doi: 10.1128/AAC.03579-14. Epub 2014 Aug 18.


Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study.

Krishnan NP, Nguyen NQ, Papp-Wallace KM, Bonomo RA, van den Akker F.

PLoS One. 2015 Sep 4;10(9):e0136813. doi: 10.1371/journal.pone.0136813. eCollection 2015.


Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC β-lactamases.

Lahiri SD, Mangani S, Durand-Reville T, Benvenuti M, De Luca F, Sanyal G, Docquier JD.

Antimicrob Agents Chemother. 2013 Jun;57(6):2496-505. doi: 10.1128/AAC.02247-12. Epub 2013 Feb 25.


Inhibitory activity of avibactam against selected β-lactamases expressed in an isogenic Escherichia coli strain.

Giani T, Cannatelli A, Di Pilato V, Testa R, Nichols WW, Rossolini GM.

Diagn Microbiol Infect Dis. 2016 Sep;86(1):83-5. doi: 10.1016/j.diagmicrobio.2016.03.002. Epub 2016 Mar 2.


Avibactam and class C β-lactamases: mechanism of inhibition, conservation of the binding pocket, and implications for resistance.

Lahiri SD, Johnstone MR, Ross PL, McLaughlin RE, Olivier NB, Alm RA.

Antimicrob Agents Chemother. 2014 Oct;58(10):5704-13. doi: 10.1128/AAC.03057-14. Epub 2014 Jul 14.


Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single β-lactamases.

Papp-Wallace KM, Bajaksouzian S, Abdelhamed AM, Foster AN, Winkler ML, Gatta JA, Nichols WW, Testa R, Bonomo RA, Jacobs MR.

Diagn Microbiol Infect Dis. 2015 May;82(1):65-9. doi: 10.1016/j.diagmicrobio.2015.02.003. Epub 2015 Feb 14.


Structural and sequence analysis of class A β-lactamases with respect to avibactam inhibition: impact of Ω-loop variations.

Lahiri SD, Bradford PA, Nichols WW, Alm RA.

J Antimicrob Chemother. 2016 Oct;71(10):2848-55. doi: 10.1093/jac/dkw248. Epub 2016 Jul 7.


Structural Insights into the TLA-3 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam and OP0595.

Jin W, Wachino JI, Yamaguchi Y, Kimura K, Kumar A, Yamada M, Morinaka A, Sakamaki Y, Yonezawa M, Kurosaki H, Arakawa Y.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00501-17. doi: 10.1128/AAC.00501-17. Print 2017 Oct.


Relebactam Is a Potent Inhibitor of the KPC-2 β-Lactamase and Restores Imipenem Susceptibility in KPC-Producing Enterobacteriaceae.

Papp-Wallace KM, Barnes MD, Alsop J, Taracila MA, Bethel CR, Becka SA, van Duin D, Kreiswirth BN, Kaye KS, Bonomo RA.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00174-18. doi: 10.1128/AAC.00174-18. Print 2018 Jun.


Exploring the Landscape of Diazabicyclooctane (DBO) Inhibition: Avibactam Inactivation of PER-2 β-Lactamase.

Ruggiero M, Papp-Wallace KM, Taracila MA, Mojica MF, Bethel CR, Rudin SD, Zeiser ET, Gutkind G, Bonomo RA, Power P.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02476-16. doi: 10.1128/AAC.02476-16. Print 2017 Jun.


In vitro antibacterial activity of the ceftazidime-avibactam combination against enterobacteriaceae, including strains with well-characterized β-lactamases.

Levasseur P, Girard AM, Miossec C, Pace J, Coleman K.

Antimicrob Agents Chemother. 2015 Apr;59(4):1931-4. doi: 10.1128/AAC.04218-14. Epub 2015 Jan 12.


Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.

Sulton D, Pagan-Rodriguez D, Zhou X, Liu Y, Hujer AM, Bethel CR, Helfand MS, Thomson JM, Anderson VE, Buynak JD, Ng LM, Bonomo RA.

J Biol Chem. 2005 Oct 21;280(42):35528-36. Epub 2005 Jun 29.


Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor combination.

Zhanel GG, Lawson CD, Adam H, Schweizer F, Zelenitsky S, Lagacé-Wiens PR, Denisuik A, Rubinstein E, Gin AS, Hoban DJ, Lynch JP 3rd, Karlowsky JA.

Drugs. 2013 Feb;73(2):159-77. doi: 10.1007/s40265-013-0013-7. Review.


OP0595, a new diazabicyclooctane: mode of action as a serine β-lactamase inhibitor, antibiotic and β-lactam 'enhancer'.

Morinaka A, Tsutsumi Y, Yamada M, Suzuki K, Watanabe T, Abe T, Furuuchi T, Inamura S, Sakamaki Y, Mitsuhashi N, Ida T, Livermore DM.

J Antimicrob Chemother. 2015 Oct;70(10):2779-86. doi: 10.1093/jac/dkv166. Epub 2015 Jun 18.


Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.

Helfand MS, Bethel CR, Hujer AM, Hujer KM, Anderson VE, Bonomo RA.

J Biol Chem. 2003 Dec 26;278(52):52724-9. Epub 2003 Oct 8.


The pharmacodynamics of avibactam in combination with ceftaroline or ceftazidime against β-lactamase-producing Enterobacteriaceae studied in an in vitro model of infection.

MacGowan A, Tomaselli S, Noel A, Bowker K.

J Antimicrob Chemother. 2017 Mar 1;72(3):762-769. doi: 10.1093/jac/dkw480.


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