Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 84

1.

C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action.

Murza A, Besserer-Offroy É, Côté J, Bérubé P, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Sarret P, Marsault É.

J Med Chem. 2015 Mar 12;58(5):2431-40. doi: 10.1021/jm501916k. Epub 2015 Feb 24.

PMID:
25668242
2.

The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment.

Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P.

Pharmacol Res. 2018 May;131:7-16. doi: 10.1016/j.phrs.2018.02.032. Epub 2018 Mar 9.

PMID:
29530600
3.

Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability.

Murza A, Parent A, Besserer-Offroy E, Tremblay H, Karadereye F, Beaudet N, Leduc R, Sarret P, Marsault É.

ChemMedChem. 2012 Feb 6;7(2):318-25. doi: 10.1002/cmdc.201100492. Epub 2011 Dec 13.

PMID:
22170700
4.

By interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization.

Iturrioz X, Gerbier R, Leroux V, Alvear-Perez R, Maigret B, Llorens-Cortes C.

J Biol Chem. 2010 Oct 15;285(42):32627-37. doi: 10.1074/jbc.M110.127167. Epub 2010 Jul 30.

5.

Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure.

El Messari S, Iturrioz X, Fassot C, De Mota N, Roesch D, Llorens-Cortes C.

J Neurochem. 2004 Sep;90(6):1290-301.

6.

Structure-activity relationship of novel macrocyclic biased apelin receptor agonists.

Murza A, Sainsily X, Côté J, Bruneau-Cossette L, Besserer-Offroy É, Longpré JM, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É.

Org Biomol Chem. 2017 Jan 4;15(2):449-458. doi: 10.1039/c6ob02247b.

PMID:
27924341
7.

[Functional dissociation between apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure].

Iturrioz X, El Messari S, De Mota N, Fassot C, Alvear-Perez R, Maigret B, Llorens-Cortes C.

Arch Mal Coeur Vaiss. 2007 Aug;100(8):704-8. French.

PMID:
17928781
8.

Evaluation of novel cyclic analogues of apelin.

Hamada J, Kimura J, Ishida J, Kohda T, Morishita S, Ichihara S, Fukamizu A.

Int J Mol Med. 2008 Oct;22(4):547-52.

PMID:
18813863
9.

New structural insights into the apelin receptor: identification of key residues for apelin binding.

Gerbier R, Leroux V, Couvineau P, Alvear-Perez R, Maigret B, Llorens-Cortes C, Iturrioz X.

FASEB J. 2015 Jan;29(1):314-22. doi: 10.1096/fj.14-256339. Epub 2014 Oct 30.

PMID:
25359495
10.

Cardiovascular responses to apelin in two-kidney-one-clip hypertensive rats and its receptor expression in ischemic and non-ischemic kidneys.

Soltani Hekmat A, Najafipour H, Nekooian AA, Esmaeli-Mahani S, Javanmardi K.

Regul Pept. 2011 Dec 10;172(1-3):62-8. doi: 10.1016/j.regpep.2011.08.010. Epub 2011 Sep 10.

PMID:
21911011
11.

Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin.

Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, Lawrie KW, Hervieu G, Riley G, Bolaky JE, Herrity NC, Murdock P, Darker JG.

J Neurochem. 2003 Mar;84(5):1162-72.

12.

Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling.

Chen X, Bai B, Tian Y, Du H, Chen J.

J Biol Chem. 2014 Nov 7;289(45):31173-87. doi: 10.1074/jbc.M114.574020. Epub 2014 Sep 30.

13.

Identifying structural determinants of potency for analogs of apelin-13: integration of C-terminal truncation with structure-activity.

Zhang Y, Maitra R, Harris DL, Dhungana S, Snyder R, Runyon SP.

Bioorg Med Chem. 2014 Jun 1;22(11):2992-7. doi: 10.1016/j.bmc.2014.04.001. Epub 2014 Apr 13.

PMID:
24755525
14.

Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13.

Moon MJ, Oh DY, Moon JS, Kim DK, Hwang JI, Lee JY, Kim JI, Cho S, Kwon HB, Seong JY.

Mol Cell Endocrinol. 2007 Oct 15;277(1-2):51-60. Epub 2007 Aug 2.

PMID:
17825479
15.

Structural and functional study of the apelin-13 peptide, an endogenous ligand of the HIV-1 coreceptor, APJ.

Fan X, Zhou N, Zhang X, Mukhtar M, Lu Z, Fang J, DuBois GC, Pomerantz RJ.

Biochemistry. 2003 Sep 2;42(34):10163-8.

PMID:
12939143
16.

Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling.

Galon-Tilleman H, Yang H, Bednarek MA, Spurlock SM, Paavola KJ, Ko B, To C, Luo J, Tian H, Jermutus L, Grimsby J, Rondinone CM, Konkar A, Kaplan DD.

J Biol Chem. 2017 Feb 3;292(5):1925-1933. doi: 10.1074/jbc.M116.748103. Epub 2016 Dec 19.

17.

Structure-activity relationship studies toward the discovery of selective apelin receptor agonists.

Margathe JF, Iturrioz X, Alvear-Perez R, Marsol C, Riché S, Chabane H, Tounsi N, Kuhry M, Heissler D, Hibert M, Llorens-Cortes C, Bonnet D.

J Med Chem. 2014 Apr 10;57(7):2908-19. doi: 10.1021/jm401789v. Epub 2014 Mar 27.

PMID:
24625069
18.

G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility.

Hashimoto Y, Ishida J, Yamamoto R, Fujiwara K, Asada S, Kasuya Y, Mochizuki N, Fukamizu A.

Int J Mol Med. 2005 Nov;16(5):787-92.

PMID:
16211245
19.

Structural insight into G-protein coupled receptor binding by apelin.

Langelaan DN, Bebbington EM, Reddy T, Rainey JK.

Biochemistry. 2009 Jan 27;48(3):537-48. doi: 10.1021/bi801864b.

PMID:
19123778
20.

Apelin ameliorates TNF-α-induced reduction of glycogen synthesis in the hepatocytes through G protein-coupled receptor APJ.

Chu J, Zhang H, Huang X, Lin Y, Shen T, Chen B, Man Y, Wang S, Li J.

PLoS One. 2013;8(2):e57231. doi: 10.1371/journal.pone.0057231. Epub 2013 Feb 21. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/15dd6d58-5cea-4252-94a6-52778c6ee55e.

Supplemental Content

Support Center