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Items: 1 to 20 of 42

1.

F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.

Liu Y, Lear T, Zhao Y, Zhao J, Zou C, Chen BB, Mallampalli RK.

Cell Death Dis. 2015 Feb 5;6:e1630. doi: 10.1038/cddis.2014.585.

2.

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.

Liu Y, Lear T, Iannone O, Shiva S, Corey C, Rajbhandari S, Jerome J, Chen BB, Mallampalli RK.

J Biol Chem. 2015 May 8;290(19):11843-52. doi: 10.1074/jbc.M114.629931. Epub 2015 Mar 16.

3.

SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation.

Zhao J, Mialki RK, Wei J, Coon TA, Zou C, Chen BB, Mallampalli RK, Zhao Y.

FASEB J. 2013 Jul;27(7):2611-9. doi: 10.1096/fj.12-223099. Epub 2013 Mar 19.

4.

A new mechanism of RhoA ubiquitination and degradation: roles of SCF(FBXL19) E3 ligase and Erk2.

Wei J, Mialki RK, Dong S, Khoo A, Mallampalli RK, Zhao Y, Zhao J.

Biochim Biophys Acta. 2013 Dec;1833(12):2757-2764. doi: 10.1016/j.bbamcr.2013.07.005. Epub 2013 Jul 18.

5.

Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.

Ding X, Barodia SK, Ma L, Goldberg MS.

Neurobiol Dis. 2017 Feb;98:122-136. doi: 10.1016/j.nbd.2016.11.004. Epub 2016 Nov 24.

6.

Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron.

Lai Y, Li J, Li X, Zou C.

J Cell Sci. 2017 Oct 15;130(20):3578-3587. doi: 10.1242/jcs.206904. Epub 2017 Sep 7.

7.

The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt.

Zhang J, Yang Z, Ou J, Xia X, Zhi F, Cui J.

FEBS Lett. 2017 Jan;591(1):145-154. doi: 10.1002/1873-3468.12521. Epub 2016 Dec 20.

8.

Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.

Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser MG, Wucherpfenning KW, Marto JA, Kaelin WG Jr.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15372-7. doi: 10.1073/pnas.1522006112. Epub 2015 Dec 2.

9.

Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death.

Lutz M, Wempe F, Bahr I, Zopf D, von Melchner H.

FEBS Lett. 2006 Jul 10;580(16):3921-30. Epub 2006 Jun 21.

10.

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.

Duan S, Cermak L, Pagan JK, Rossi M, Martinengo C, di Celle PF, Chapuy B, Shipp M, Chiarle R, Pagano M.

Nature. 2012 Jan 5;481(7379):90-3. doi: 10.1038/nature10688.

11.

F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation.

Li D, Xie P, Zhao F, Shu J, Li L, Zhan Y, Zhang L.

Biochem Biophys Res Commun. 2015 Mar 20;458(4):941-5. doi: 10.1016/j.bbrc.2015.02.089. Epub 2015 Feb 24.

PMID:
25721664
12.

Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B.

van de Kooij B, Rooswinkel RW, Kok F, Herrebout M, de Vries E, Paauwe M, Janssen GM, van Veelen PA, Borst J.

Oncogene. 2013 Nov 28;32(48):5439-48. doi: 10.1038/onc.2013.99. Epub 2013 Apr 8.

13.

FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.

Watanabe K, Yumimoto K, Nakayama KI.

Genes Cells. 2015 Aug;20(8):667-74. doi: 10.1111/gtc.12260. Epub 2015 Jun 18.

14.

SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation.

Zou C, Chen Y, Smith RM, Snavely C, Li J, Coon TA, Chen BB, Zhao Y, Mallampalli RK.

J Biol Chem. 2013 Mar 1;288(9):6306-16. doi: 10.1074/jbc.M112.426882. Epub 2013 Jan 14.

15.
16.

Spironolactone-induced XPB degradation depends on CDK7 kinase and SCFFBXL18 E3 ligase.

Ueda M, Matsuura K, Kawai H, Wakasugi M, Matsunaga T.

Genes Cells. 2019 Apr;24(4):284-296. doi: 10.1111/gtc.12674. Epub 2019 Mar 18.

17.

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.

Chen X, Sahasrabuddhe AA, Szankasi P, Chung F, Basrur V, Rangnekar VM, Pagano M, Lim MS, Elenitoba-Johnson KS.

Cell Death Differ. 2014 Oct;21(10):1535-45. doi: 10.1038/cdd.2014.92. Epub 2014 Jul 4.

18.

F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest.

Chen BB, Glasser JR, Coon TA, Mallampalli RK.

Oncogene. 2012 May 17;31(20):2566-79. doi: 10.1038/onc.2011.432. Epub 2011 Oct 24.

19.

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A, Phu L, Arnott D, Aghajan M, Zobel K, Bazan JF, Fairbrother WJ, Deshayes K, Vucic D.

Biochem J. 2009 Jan 1;417(1):149-60. doi: 10.1042/BJ20081885.

PMID:
18939944
20.

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade.

Kuchay S, Duan S, Schenkein E, Peschiaroli A, Saraf A, Florens L, Washburn MP, Pagano M.

Nat Cell Biol. 2013 May;15(5):472-80. doi: 10.1038/ncb2731. Epub 2013 Apr 21.

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