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Items: 1 to 20 of 93

1.

TIM-1 signaling is required for maintenance and induction of regulatory B cells.

Yeung MY, Ding Q, Brooks CR, Xiao S, Workman CJ, Vignali DA, Ueno T, Padera RF, Kuchroo VK, Najafian N, Rothstein DM.

Am J Transplant. 2015 Apr;15(4):942-53. doi: 10.1111/ajt.13087. Epub 2015 Feb 2.

2.

Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation.

Xiao S, Brooks CR, Sobel RA, Kuchroo VK.

J Immunol. 2015 Feb 15;194(4):1602-8. doi: 10.4049/jimmunol.1402632. Epub 2015 Jan 12.

3.

Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.

Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12105-10. doi: 10.1073/pnas.1120914109. Epub 2012 Jul 5.

4.

Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice.

Ding Q, Yeung M, Camirand G, Zeng Q, Akiba H, Yagita H, Chalasani G, Sayegh MH, Najafian N, Rothstein DM.

J Clin Invest. 2011 Sep;121(9):3645-56. doi: 10.1172/JCI46274. Epub 2011 Aug 8.

5.

Identification of the Subsets of IL-10-Producing Regulatory B Cells in the Course of Tolerance Induction and Maintenance in Islet Allotransplantation.

Li S, Li X, Yang M, Wei L, Wei L, Deng S, Zhao G.

Transplant Proc. 2018 Dec;50(10):3900-3905. doi: 10.1016/j.transproceed.2018.04.065. Epub 2018 May 4.

PMID:
30577284
6.

TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients.

Aravena O, Ferrier A, Menon M, Mauri C, Aguillón JC, Soto L, Catalán D.

Arthritis Res Ther. 2017 Jan 19;19(1):8. doi: 10.1186/s13075-016-1213-9.

7.

TIM-4 Identifies IFN-γ-Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection.

Ding Q, Mohib K, Kuchroo VK, Rothstein DM.

J Immunol. 2017 Oct 1;199(7):2585-2595. doi: 10.4049/jimmunol.1602107. Epub 2017 Aug 28.

8.

Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival.

Yeung MY, McGrath MM, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka LA, Najafian N.

J Immunol. 2013 Oct 15;191(8):4447-55. doi: 10.4049/jimmunol.1300992. Epub 2013 Sep 13.

9.

Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.

Foks AC, Engelbertsen D, Kuperwaser F, Alberts-Grill N, Gonen A, Witztum JL, Lederer J, Jarolim P, DeKruyff RH, Freeman GJ, Lichtman AH.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):456-65. doi: 10.1161/ATVBAHA.115.306860. Epub 2016 Jan 28.

10.

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.

Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10734-9. doi: 10.1073/pnas.0812538106. Epub 2009 Jun 15.

11.

Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response.

Wong SH, Barlow JL, Nabarro S, Fallon PG, McKenzie AN.

Immunology. 2010 Sep;131(1):77-88. doi: 10.1111/j.1365-2567.2010.03276.x. Epub 2010 May 26.

12.

The amelioration of composite tissue allograft rejection by TIM-3-modified dendritic cell: Regulation of the balance of regulatory and effector T cells.

Wang Y, Zheng Z, Zhu X, Han J, Dong M, Tao K, Wang H, Wang Y, Hu D.

Immunol Lett. 2016 Jan;169:15-22. doi: 10.1016/j.imlet.2015.11.004. Epub 2015 Nov 10.

PMID:
26561949
13.

Tim-1 blockade with RMT1-10 increases T regulatory cells and prolongs the survival of high-risk corneal allografts in mice.

Tan X, Jie Y, Zhang Y, Qin Y, Xu Q, Pan Z.

Exp Eye Res. 2014 May;122:86-93. doi: 10.1016/j.exer.2014.02.019. Epub 2014 Mar 5.

PMID:
24613782
14.

TIM-3: a novel regulatory molecule of alloimmune activation.

Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N.

J Immunol. 2010 Nov 15;185(10):5806-19. doi: 10.4049/jimmunol.0903435. Epub 2010 Oct 18.

15.

Tim-1-Fc suppresses chronic cardiac allograft rejection and vasculopathy by reducing IL-17 production.

Shi X, Zhang M, Liu F, Wang Z, Zhang L, Cheng H, Zhang S, Fei T, Guo M, Bian J, Wang Q, Ding G.

Int J Clin Exp Pathol. 2014 Jan 15;7(2):509-20. eCollection 2014.

16.

Suppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells.

Xiao L, Fu ZR, Liu F, Zhang LD, Shi XM, Shen XY, Ni ZJ, Fu H, Li RD, Cao XT, Ding GS, Wang QX.

PLoS One. 2011;6(7):e21697. doi: 10.1371/journal.pone.0021697. Epub 2011 Jul 5.

17.

Disruption of TIM-4 in dendritic cell ameliorates hepatic warm IR injury through the induction of regulatory T cells.

Li J, Zhao X, Liu X, Liu H.

Mol Immunol. 2015 Aug;66(2):117-25. doi: 10.1016/j.molimm.2015.02.004. Epub 2015 Mar 12.

PMID:
25771178
18.

Tim-1+ B cells suppress T cell interferon-gamma production and promote Foxp3 expression, but have impaired regulatory function in coronary artery disease.

Gu XL, He H, Lin L, Luo GX, Wen YF, Xiang DC, Qiu J.

APMIS. 2017 Oct;125(10):872-879. doi: 10.1111/apm.12729. Epub 2017 Jul 24.

PMID:
28736945
19.

The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease.

Kaneyama T, Tomiki H, Tsugane S, Inaba Y, Ichikawa M, Akiba H, Yagita H, Kim BS, Koh CS.

Int Immunol. 2014 Jul;26(7):369-81. doi: 10.1093/intimm/dxt056. Epub 2014 Jan 31.

PMID:
24486565
20.

The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse.

Uchida Y, Ke B, Freitas MC, Ji H, Zhao D, Benjamin ER, Najafian N, Yagita H, Akiba H, Busuttil RW, Kupiec-Weglinski JW.

Hepatology. 2010 Apr;51(4):1363-72. doi: 10.1002/hep.23442.

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