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Items: 1 to 20 of 138

1.

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.

Agirre X, Castellano G, Pascual M, Heath S, Kulis M, Segura V, Bergmann A, Esteve A, Merkel A, Raineri E, Agueda L, Blanc J, Richardson D, Clarke L, Datta A, Russiñol N, Queirós AC, Beekman R, Rodríguez-Madoz JR, San José-Enériz E, Fang F, Gutiérrez NC, García-Verdugo JM, Robson MI, Schirmer EC, Guruceaga E, Martens JH, Gut M, Calasanz MJ, Flicek P, Siebert R, Campo E, Miguel JF, Melnick A, Stunnenberg HG, Gut IG, Prosper F, Martín-Subero JI.

Genome Res. 2015 Apr;25(4):478-87. doi: 10.1101/gr.180240.114. Epub 2015 Feb 2.

2.

Hypermethylated LTR retrotransposon exhibits enhancer activity.

Hu T, Zhu X, Pi W, Yu M, Shi H, Tuan D.

Epigenetics. 2017 Mar 4;12(3):226-237. doi: 10.1080/15592294.2017.1289300. Epub 2017 Feb 6.

3.

Intragenic CpG islands play important roles in bivalent chromatin assembly of developmental genes.

Lee SM, Lee J, Noh KM, Choi WY, Jeon S, Oh GT, Kim-Ha J, Jin Y, Cho SW, Kim YJ.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1885-E1894. doi: 10.1073/pnas.1613300114. Epub 2017 Feb 21.

4.

An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells.

Holm K, Staaf J, Lauss M, Aine M, Lindgren D, Bendahl PO, Vallon-Christersson J, Barkardottir RB, Höglund M, Borg Å, Jönsson G, Ringnér M.

Breast Cancer Res. 2016 Feb 29;18(1):27. doi: 10.1186/s13058-016-0685-5.

5.

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia.

Akalin A, Garrett-Bakelman FE, Kormaksson M, Busuttil J, Zhang L, Khrebtukova I, Milne TA, Huang Y, Biswas D, Hess JL, Allis CD, Roeder RG, Valk PJ, Löwenberg B, Delwel R, Fernandez HF, Paietta E, Tallman MS, Schroth GP, Mason CE, Melnick A, Figueroa ME.

PLoS Genet. 2012;8(6):e1002781. doi: 10.1371/journal.pgen.1002781. Epub 2012 Jun 21.

6.

Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer.

Bae MG, Kim JY, Choi JK.

BMC Med Genomics. 2016 Aug 12;9 Suppl 1:38. doi: 10.1186/s12920-016-0198-1.

7.

The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers.

Harten SK, Oey H, Bourke LM, Bharti V, Isbel L, Daxinger L, Faou P, Robertson N, Matthews JM, Whitelaw E.

BMC Biol. 2015 Mar 26;13:21. doi: 10.1186/s12915-015-0128-2.

8.

5'-Hydroxymethylcytosine Precedes Loss of CpG Methylation in Enhancers and Genes Undergoing Activation in Cardiomyocyte Maturation.

Kranzhöfer DK, Gilsbach R, Grüning BA, Backofen R, Nührenberg TG, Hein L.

PLoS One. 2016 Nov 16;11(11):e0166575. doi: 10.1371/journal.pone.0166575. eCollection 2016.

9.

Kidney cancer is characterized by aberrant methylation of tissue-specific enhancers that are prognostic for overall survival.

Hu CY, Mohtat D, Yu Y, Ko YA, Shenoy N, Bhattacharya S, Izquierdo MC, Park AS, Giricz O, Vallumsetla N, Gundabolu K, Ware K, Bhagat TD, Suzuki M, Pullman J, Liu XS, Greally JM, Susztak K, Verma A.

Clin Cancer Res. 2014 Aug 15;20(16):4349-60. doi: 10.1158/1078-0432.CCR-14-0494. Epub 2014 Jun 10.

10.

Genome-wide DNA methylation analysis reveals molecular subtypes of pancreatic cancer.

Mishra NK, Guda C.

Oncotarget. 2017 Apr 25;8(17):28990-29012. doi: 10.18632/oncotarget.15993.

11.

Genome-wide methylation sequencing of paired primary and metastatic cell lines identifies common DNA methylation changes and a role for EBF3 as a candidate epigenetic driver of melanoma metastasis.

Chatterjee A, Stockwell PA, Ahn A, Rodger EJ, Leichter AL, Eccles MR.

Oncotarget. 2017 Jan 24;8(4):6085-6101. doi: 10.18632/oncotarget.14042.

12.

Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.

Yuan J, Luo RZ, Fujii S, Wang L, Hu W, Andreeff M, Pan Y, Kadota M, Oshimura M, Sahin AA, Issa JP, Bast RC Jr, Yu Y.

Cancer Res. 2003 Jul 15;63(14):4174-80.

13.

Hypomethylation coordinates antagonistically with hypermethylation in cancer development: a case study of leukemia.

Kushwaha G, Dozmorov M, Wren JD, Qiu J, Shi H, Xu D.

Hum Genomics. 2016 Jul 25;10 Suppl 2:18. doi: 10.1186/s40246-016-0071-5.

14.

Aberrant CpG island hypermethylation and down-regulation of Oct-6 mRNA expression in human hepatocellular carcinoma.

Sun JZ, Yang XX, Li XH, Xu WW, Wang Y, Zhu W, Li M.

Dig Dis Sci. 2011 Oct;56(10):3072-7. doi: 10.1007/s10620-011-1686-y. Epub 2011 Mar 30.

PMID:
21448695
15.

DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease.

Jeziorska DM, Murray RJS, De Gobbi M, Gaentzsch R, Garrick D, Ayyub H, Chen T, Li E, Telenius J, Lynch M, Graham B, Smith AJH, Lund JN, Hughes JR, Higgs DR, Tufarelli C.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7526-E7535. doi: 10.1073/pnas.1703087114. Epub 2017 Aug 21.

16.

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.

Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, He R, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Kantarjian HM, Liang S, Estecio MR, Godley LA, Issa JP.

Cancer Res. 2015 Jul 15;75(14):2833-43. doi: 10.1158/0008-5472.CAN-14-0739. Epub 2015 May 13.

17.

Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73.

van Doorn R, Zoutman WH, Dijkman R, de Menezes RX, Commandeur S, Mulder AA, van der Velden PA, Vermeer MH, Willemze R, Yan PS, Huang TH, Tensen CP.

J Clin Oncol. 2005 Jun 10;23(17):3886-96. Epub 2005 May 16.

PMID:
15897551
18.

Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas.

Peng D, Hu TL, Jiang A, Washington MK, Moskaluk CA, Schneider-Stock R, El-Rifai W.

PLoS One. 2011;6(7):e22009. doi: 10.1371/journal.pone.0022009. Epub 2011 Jul 19.

19.

Genome-wide DNA methylation sequencing reveals miR-663a is a novel epimutation candidate in CIMP-high endometrial cancer.

Yanokura M, Banno K, Adachi M, Aoki D, Abe K.

Int J Oncol. 2017 Jun;50(6):1934-1946. doi: 10.3892/ijo.2017.3966. Epub 2017 Apr 19.

20.

Global epigenetic regulation of microRNAs in multiple myeloma.

Zhang W, Wang YE, Zhang Y, Leleu X, Reagan M, Zhang Y, Mishima Y, Glavey S, Manier S, Sacco A, Jiang B, Roccaro AM, Ghobrial IM.

PLoS One. 2014 Oct 17;9(10):e110973. doi: 10.1371/journal.pone.0110973. eCollection 2014.

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