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Items: 1 to 20 of 119

1.

Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia.

Khan MP, Singh AK, Joharapurkar AA, Yadav M, Shree S, Kumar H, Gurjar A, Mishra JS, Tiwari MC, Nagar GK, Kumar S, Ramachandran R, Sharan A, Jain MR, Trivedi AK, Maurya R, Godbole MM, Gayen JR, Sanyal S, Chattopadhyay N.

Diabetes. 2015 Jul;64(7):2609-23. doi: 10.2337/db14-1611. Epub 2015 Jan 29. Erratum in: Diabetes. 2017 Dec;66(12 ):3142-3143.

2.

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.

Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T.

Nature. 2013 Nov 28;503(7477):493-9. doi: 10.1038/nature12656. Epub 2013 Oct 30.

PMID:
24172895
3.

Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy.

Singh AK, Shree S, Chattopadhyay S, Kumar S, Gurjar A, Kushwaha S, Kumar H, Trivedi AK, Chattopadhyay N, Maurya R, Ramachandran R, Sanyal S.

Mol Cell Endocrinol. 2017 Jan 5;439:273-285. doi: 10.1016/j.mce.2016.09.013. Epub 2016 Sep 16.

PMID:
27645900
4.

Orally active osteoanabolic agent GTDF binds to adiponectin receptors, with a preference for AdipoR1, induces adiponectin-associated signaling, and improves metabolic health in a rodent model of diabetes.

Singh AK, Joharapurkar AA, Khan MP, Mishra JS, Singh N, Yadav M, Hossain Z, Khan K, Kumar S, Dhanesha NA, Mishra DP, Maurya R, Sharma S, Jain MR, Trivedi AK, Godbole MM, Gayen JR, Chattopadhyay N, Sanyal S.

Diabetes. 2014 Oct;63(10):3530-44. doi: 10.2337/db13-1619. Epub 2014 May 21.

5.

Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy.

Park HS, Lim JH, Kim MY, Kim Y, Hong YA, Choi SR, Chung S, Kim HW, Choi BS, Kim YS, Chang YS, Park CW.

J Transl Med. 2016 Jun 11;14(1):176. doi: 10.1186/s12967-016-0922-9. Erratum in: J Transl Med. 2016;14(1):210.

7.

An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation.

Miura S, Kawanaka K, Kai Y, Tamura M, Goto M, Shiuchi T, Minokoshi Y, Ezaki O.

Endocrinology. 2007 Jul;148(7):3441-8. Epub 2007 Apr 19.

PMID:
17446185
8.

Erratum. Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia. Diabetes 2015;64:2609-2623.

Khan MP, Singh AK, Joharapurkar AA, Yadav M, Shree S, Kumar H, Gurjar A, Mishra JS, Tiwari MC, Nagar GK, Kumar S, Ramachandran R, Sharan A, Jain MR, Trivedi AK, Maurya R, Godbole MM, Gayen JR, Sanyal S, Chattopadhyay N.

Diabetes. 2017 Dec;66(12):3142-3143. doi: 10.2337/db17-er12b. Epub 2017 Oct 5. No abstract available.

9.

Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.

Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T.

Nature. 2010 Apr 29;464(7293):1313-9. doi: 10.1038/nature08991. Epub 2010 Mar 31.

PMID:
20357764
10.

The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.

Kim Y, Lim JH, Kim MY, Kim EN, Yoon HE, Shin SJ, Choi BS, Kim YS, Chang YS, Park CW.

J Am Soc Nephrol. 2018 Apr;29(4):1108-1127. doi: 10.1681/ASN.2017060627. Epub 2018 Jan 12.

11.

PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity.

Lira VA, Benton CR, Yan Z, Bonen A.

Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E145-61. doi: 10.1152/ajpendo.00755.2009. Epub 2010 Apr 6. Review.

12.

Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation.

Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, Ruas JL, Haibe-Kains B, Estall JL.

Am J Physiol Endocrinol Metab. 2014 Jan 15;306(2):E157-67. doi: 10.1152/ajpendo.00578.2013. Epub 2013 Nov 26.

13.

Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.

Koentges C, König A, Pfeil K, Hölscher ME, Schnick T, Wende AR, Schrepper A, Cimolai MC, Kersting S, Hoffmann MM, Asal J, Osterholt M, Odening KE, Doenst T, Hein L, Abel ED, Bode C, Bugger H.

Basic Res Cardiol. 2015;110(4):37. doi: 10.1007/s00395-015-0495-4. Epub 2015 May 16.

PMID:
25982881
14.
15.

Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice.

Zhang LN, Zhou HY, Fu YY, Li YY, Wu F, Gu M, Wu LY, Xia CM, Dong TC, Li JY, Shen JK, Li J.

Diabetes. 2013 Apr;62(4):1297-307. doi: 10.2337/db12-0703. Epub 2012 Dec 18.

16.

Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity.

Liang H, Balas B, Tantiwong P, Dube J, Goodpaster BH, O'Doherty RM, DeFronzo RA, Richardson A, Musi N, Ward WF.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E945-54. doi: 10.1152/ajpendo.90292.2008. Epub 2009 Feb 10.

17.

Hyperhomocysteinemia attenuates angiogenesis through reduction of HIF-1α and PGC-1α levels in muscle fibers during hindlimb ischemia.

Veeranki S, Givvimani S, Pushpakumar S, Tyagi SC.

Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1116-27. doi: 10.1152/ajpheart.00003.2014. Epub 2014 Feb 28.

18.

PGC-1α over-expression suppresses the skeletal muscle atrophy and myofiber-type composition during hindlimb unloading.

Wang J, Wang F, Zhang P, Liu H, He J, Zhang C, Fan M, Chen X.

Biosci Biotechnol Biochem. 2017 Mar;81(3):500-513. doi: 10.1080/09168451.2016.1254531. Epub 2016 Nov 21.

PMID:
27869526
19.

Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program.

Hindi SM, Mishra V, Bhatnagar S, Tajrishi MM, Ogura Y, Yan Z, Burkly LC, Zheng TS, Kumar A.

FASEB J. 2014 Mar;28(3):1398-411. doi: 10.1096/fj.13-242123. Epub 2013 Dec 10.

20.

Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1alpha) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats.

Benton CR, Holloway GP, Han XX, Yoshida Y, Snook LA, Lally J, Glatz JF, Luiken JJ, Chabowski A, Bonen A.

Diabetologia. 2010 Sep;53(9):2008-19. doi: 10.1007/s00125-010-1773-1. Epub 2010 May 20.

PMID:
20490453

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