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Items: 1 to 20 of 129

1.

Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery.

Rodionova IA, Zuccola HJ, Sorci L, Aleshin AE, Kazanov MD, Ma CT, Sergienko E, Rubin EJ, Locher CP, Osterman AL.

J Biol Chem. 2015 Mar 20;290(12):7693-706. doi: 10.1074/jbc.M114.628016. Epub 2015 Jan 28.

2.

Metabolic and bactericidal effects of targeted suppression of NadD and NadE enzymes in mycobacteria.

Rodionova IA, Schuster BM, Guinn KM, Sorci L, Scott DA, Li X, Kheterpal I, Shoen C, Cynamon M, Locher C, Rubin EJ, Osterman AL.

MBio. 2014 Feb 18;5(1). pii: e00747-13. doi: 10.1128/mBio.00747-13.

3.

Kinetic and X-ray structural evidence for negative cooperativity in substrate binding to nicotinate mononucleotide adenylyltransferase (NMAT) from Bacillus anthracis.

Sershon VC, Santarsiero BD, Mesecar AD.

J Mol Biol. 2009 Jan 23;385(3):867-88. doi: 10.1016/j.jmb.2008.10.037. Epub 2008 Oct 19.

5.

Crystal structure of nicotinic acid mononucleotide adenylyltransferase from Staphyloccocus aureus: structural basis for NaAD interaction in functional dimer.

Han S, Forman MD, Loulakis P, Rosner MH, Xie Z, Wang H, Danley DE, Yuan W, Schafer J, Xu Z.

J Mol Biol. 2006 Jul 21;360(4):814-25. Epub 2006 Jun 6.

PMID:
16784754
6.

Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.

Olland AM, Underwood KW, Czerwinski RM, Lo MC, Aulabaugh A, Bard J, Stahl ML, Somers WS, Sullivan FX, Chopra R.

J Biol Chem. 2002 Feb 1;277(5):3698-707. Epub 2001 Nov 9.

7.

Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.

Zhou T, Kurnasov O, Tomchick DR, Binns DD, Grishin NV, Marquez VE, Osterman AL, Zhang H.

J Biol Chem. 2002 Apr 12;277(15):13148-54. Epub 2002 Jan 11.

8.

Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD.

Sorci L, Pan Y, Eyobo Y, Rodionova I, Huang N, Kurnasov O, Zhong S, MacKerell AD Jr, Zhang H, Osterman AL.

Chem Biol. 2009 Aug 28;16(8):849-61. doi: 10.1016/j.chembiol.2009.07.006.

9.

Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement.

Huang N, Kolhatkar R, Eyobo Y, Sorci L, Rodionova I, Osterman AL, Mackerell AD, Zhang H.

J Med Chem. 2010 Jul 22;53(14):5229-39. doi: 10.1021/jm100377f.

10.

Structure of nicotinamide mononucleotide adenylyltransferase: a key enzyme in NAD(+) biosynthesis.

D'Angelo I, Raffaelli N, Dabusti V, Lorenzi T, Magni G, Rizzi M.

Structure. 2000 Sep 15;8(9):993-1004.

11.

Nicotinamide mononucleotide adenylyltransferase displays alternate binding modes for nicotinamide nucleotides.

Pfoh R, Pai EF, Saridakis V.

Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2032-9. doi: 10.1107/S1399004715015497. Epub 2015 Sep 26.

12.

Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase.

Bathke J, Fritz-Wolf K, Brandst├Ądter C, Burkhardt A, Jortzik E, Rahlfs S, Becker K.

J Mol Biol. 2016 Dec 4;428(24 Pt B):4946-4961. doi: 10.1016/j.jmb.2016.10.023. Epub 2016 Oct 27.

PMID:
27984041
13.

Engineering Escherichia coli Nicotinic Acid Mononucleotide Adenylyltransferase for Fully Active Amidated NAD Biosynthesis.

Wang X, Zhou YJ, Wang L, Liu W, Liu Y, Peng C, Zhao ZK.

Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00692-17. doi: 10.1128/AEM.00692-17. Print 2017 Jul 1.

15.

Insights into ligand binding and catalysis of a central step in NAD+ synthesis: structures of Methanobacterium thermoautotrophicum NMN adenylyltransferase complexes.

Saridakis V, Christendat D, Kimber MS, Dharamsi A, Edwards AM, Pai EF.

J Biol Chem. 2001 Mar 9;276(10):7225-32. Epub 2000 Nov 3.

16.
17.

Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis.

Lu S, Smith CD, Yang Z, Pruett PS, Nagy L, McCombs D, Delucas LJ, Brouillette WJ, Brouillette CG.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Oct 1;64(Pt 10):893-8. doi: 10.1107/S1744309108029102. Epub 2008 Sep 30.

18.

Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD.

Zhang H, Zhou T, Kurnasov O, Cheek S, Grishin NV, Osterman A.

Structure. 2002 Jan;10(1):69-79.

19.

Crystallization and preliminary X-ray crystallographic analysis of nicotinic acid mononucleotide adenylyltransferase from Pseudomonas aeruginosa.

Kim HL, Yoon HJ, Ha JY, Lee BI, Lee HH, Mikami B, Suh SW.

Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):948-9. Epub 2004 Apr 21.

PMID:
15103148
20.

Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.

Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L.

ACS Chem Biol. 2019 May 17;14(5):949-958. doi: 10.1021/acschembio.9b00124. Epub 2019 Apr 17.

PMID:
30969758

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