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Items: 1 to 20 of 68

1.

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM.

Nat Chem Biol. 2015 Mar;11(3):189-91. doi: 10.1038/nchembio.1735. Epub 2015 Jan 26.

2.

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation.

Wang Y, Li M, Stadler S, Correll S, Li P, Wang D, Hayama R, Leonelli L, Han H, Grigoryev SA, Allis CD, Coonrod SA.

J Cell Biol. 2009 Jan 26;184(2):205-13. doi: 10.1083/jcb.200806072. Epub 2009 Jan 19.

3.

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps.

Li P, Li M, Lindberg MR, Kennett MJ, Xiong N, Wang Y.

J Exp Med. 2010 Aug 30;207(9):1853-62. doi: 10.1084/jem.20100239. Epub 2010 Aug 23.

4.

Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model.

Biron BM, Chung CS, O'Brien XM, Chen Y, Reichner JS, Ayala A.

J Innate Immun. 2017;9(1):22-32. doi: 10.1159/000448808. Epub 2016 Sep 14.

5.

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.

Bozdag M, Dreker T, Henry C, Tosco P, Vallaro M, Fruttero R, Scozzafava A, Carta F, Supuran CT.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):715-9. doi: 10.1016/j.bmcl.2012.11.102. Epub 2012 Dec 2.

6.

Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.

Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, Coonrod SA, Guo M, Thompson PR.

ACS Chem Biol. 2012 Jan 20;7(1):160-5. doi: 10.1021/cb200258q. Epub 2011 Oct 21.

7.

Facile fluorescence-based detection of PAD4-mediated citrullination.

Wildeman E, Pires MM.

Chembiochem. 2013 May 27;14(8):963-7. doi: 10.1002/cbic.201300173. Epub 2013 May 2.

PMID:
23640867
8.

Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.

Mastronardi FG, Wood DD, Mei J, Raijmakers R, Tseveleki V, Dosch HM, Probert L, Casaccia-Bonnefil P, Moscarello MA.

J Neurosci. 2006 Nov 1;26(44):11387-96.

9.

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.

Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8674-9. doi: 10.1073/pnas.1301059110. Epub 2013 May 6.

10.

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures.

Leshner M, Wang S, Lewis C, Zheng H, Chen XA, Santy L, Wang Y.

Front Immunol. 2012 Oct 4;3:307. doi: 10.3389/fimmu.2012.00307. eCollection 2012.

11.

Recognition of the N-terminal histone H2A and H3 peptides by peptidylarginine deiminase IV.

Saiki M, Watase M, Matsubayashi H, Hidaka Y.

Protein Pept Lett. 2009;16(9):1012-6. Epub 2009 Sep 1.

PMID:
19508226
12.

Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.

Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB.

Sci Adv. 2016 Feb 5;2(2):e1501257. doi: 10.1126/sciadv.1501257. eCollection 2016 Feb.

13.

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock.

Martinod K, Fuchs TA, Zitomersky NL, Wong SL, Demers M, Gallant M, Wang Y, Wagner DD.

Blood. 2015 Mar 19;125(12):1948-56. doi: 10.1182/blood-2014-07-587709. Epub 2015 Jan 26.

14.

PAD2 Activity Monitored via a Fluorescent Substrate Analog.

Sabulski MJ, Wang Y, Pires MM.

Chem Biol Drug Des. 2015 Oct;86(4):599-605. doi: 10.1111/cbdd.12526. Epub 2015 Feb 16.

PMID:
25643806
15.

Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.

Knuckley B, Causey CP, Jones JE, Bhatia M, Dreyton CJ, Osborne TC, Takahara H, Thompson PR.

Biochemistry. 2010 Jun 15;49(23):4852-63. doi: 10.1021/bi100363t.

16.

Neutrophil extracellular traps are critical for pregnancy loss in sphingosine kinase-deficient mice on 129Sv/C57BL/6 background.

Mizugishi K, Yamashita K.

FASEB J. 2017 Dec;31(12):5577-5591. doi: 10.1096/fj.201700399RR. Epub 2017 Aug 21.

PMID:
28842426
17.

Activation of PAD4 in NET formation.

Rohrbach AS, Slade DJ, Thompson PR, Mowen KA.

Front Immunol. 2012 Nov 29;3:360. doi: 10.3389/fimmu.2012.00360. eCollection 2012.

18.

Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2.

Guo Q, Bedford MT, Fast W.

Mol Biosyst. 2011 Jul;7(7):2286-95. doi: 10.1039/c1mb05089c. Epub 2011 May 16.

19.

Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3.

Clark HL, Abbondante S, Minns MS, Greenberg EN, Sun Y, Pearlman E.

Front Immunol. 2018 May 29;9:1182. doi: 10.3389/fimmu.2018.01182. eCollection 2018.

20.

Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis.

Kearney PL, Bhatia M, Jones NG, Yuan L, Glascock MC, Catchings KL, Yamada M, Thompson PR.

Biochemistry. 2005 Aug 9;44(31):10570-82.

PMID:
16060666

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