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Items: 1 to 20 of 199

1.

Hedgehog signaling is synergistically enhanced by nutritional deprivation and ligand stimulation in human fibroblasts of Gorlin syndrome.

Mizuochi H, Fujii K, Shiohama T, Uchikawa H, Shimojo N.

Biochem Biophys Res Commun. 2015 Feb 13;457(3):318-23. doi: 10.1016/j.bbrc.2014.12.108. Epub 2015 Jan 7.

PMID:
25576868
2.

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.

Svärd J, Heby-Henricson K, Persson-Lek M, Rozell B, Lauth M, Bergström A, Ericson J, Toftgård R, Teglund S.

Dev Cell. 2006 Feb;10(2):187-97. Erratum in: Dev Cell. 2006 Mar;10(3):409. Henricson, Karin Heby [corrected to Heby-Henricson, Karin].

3.

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.

Wickström M, Dyberg C, Shimokawa T, Milosevic J, Baryawno N, Fuskevåg OM, Larsson R, Kogner P, Zaphiropoulos PG, Johnsen JI.

Int J Cancer. 2013 Apr 1;132(7):1516-24. doi: 10.1002/ijc.27820. Epub 2012 Oct 3.

4.

Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.

Walter K, Omura N, Hong SM, Griffith M, Vincent A, Borges M, Goggins M.

Clin Cancer Res. 2010 Mar 15;16(6):1781-9. doi: 10.1158/1078-0432.CCR-09-1913. Epub 2010 Mar 9.

5.

Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.

Hasegawa D, Ochiai-Shino H, Onodera S, Nakamura T, Saito A, Onda T, Watanabe K, Nishimura K, Ohtaka M, Nakanishi M, Kosaki K, Yamaguchi A, Shibahara T, Azuma T.

PLoS One. 2017 Oct 31;12(10):e0186879. doi: 10.1371/journal.pone.0186879. eCollection 2017.

6.

Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.

Werminghaus P, Haase M, Hornsby PJ, Schinner S, Schott M, Malendowicz LK, Lammers BJ, Goretzki PE, Müller-Mattheis V, Markus Giessing, Willenberg HS.

J Steroid Biochem Mol Biol. 2014 Jan;139:7-15. doi: 10.1016/j.jsbmb.2013.09.007. Epub 2013 Sep 21.

PMID:
24063979
7.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

8.

Smoothened as a new therapeutic target for human osteosarcoma.

Hirotsu M, Setoguchi T, Sasaki H, Matsunoshita Y, Gao H, Nagao H, Kunigou O, Komiya S.

Mol Cancer. 2010 Jan 12;9:5. doi: 10.1186/1476-4598-9-5.

9.

Targeting hedgehog signaling pathway in pediatric tumors: in vitro evaluation of SMO and GLI inhibitors.

Arnhold V, Boos J, Lanvers-Kaminsky C.

Cancer Chemother Pharmacol. 2016 Mar;77(3):495-505. doi: 10.1007/s00280-016-2962-5. Epub 2016 Jan 19.

PMID:
26781311
10.

Hedgehog signaling drives cellular survival in human colon carcinoma cells.

Mazumdar T, DeVecchio J, Shi T, Jones J, Agyeman A, Houghton JA.

Cancer Res. 2011 Feb 1;71(3):1092-102. doi: 10.1158/0008-5472.CAN-10-2315. Epub 2010 Dec 6.

11.

Small-molecule modulators of the Sonic Hedgehog signaling pathway.

Stanton BZ, Peng LF.

Mol Biosyst. 2010 Jan;6(1):44-54. doi: 10.1039/b910196a. Epub 2009 Aug 27. Review.

PMID:
20024066
12.

Hedgehog- and mTOR-targeted therapies for advanced basal cell carcinomas.

Piérard-Franchimont C, Hermanns-Lê T, Paquet P, Herfs M, Delvenne P, Piérard GE.

Future Oncol. 2015 Nov;11(22):2997-3002. doi: 10.2217/fon.15.181. Epub 2015 Oct 5. Review.

PMID:
26437034
13.

Protein and mRNA expression of Shh, Smo and Gli1 and inhibition by cyclopamine in hepatocytes of rats with chronic fluorosis.

Zhao L, Yu Y, Deng C.

Toxicol Lett. 2014 Mar 3;225(2):318-24. doi: 10.1016/j.toxlet.2013.12.022. Epub 2014 Jan 2.

PMID:
24388991
14.

Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria.

Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL, Petricci E, Manetti F, Taddei M, Knight MM, Santucci A.

J Cell Physiol. 2017 Nov;232(11):3103-3111. doi: 10.1002/jcp.25761. Epub 2017 Mar 29.

PMID:
28019670
15.

Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma.

Lo WW, Wunder JS, Dickson BC, Campbell V, McGovern K, Alman BA, Andrulis IL.

Cancer. 2014 Feb 15;120(4):537-47. doi: 10.1002/cncr.28439. Epub 2013 Oct 21.

16.

Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells.

van der Horst G, Farih-Sips H, Löwik CW, Karperien M.

Bone. 2003 Dec;33(6):899-910.

PMID:
14678849
17.

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.

Hu MC, Mo R, Bhella S, Wilson CW, Chuang PT, Hui CC, Rosenblum ND.

Development. 2006 Feb;133(3):569-78. Epub 2006 Jan 5.

18.

Targeting the hedgehog-glioma-associated oncogene homolog pathway inhibits bleomycin-induced lung fibrosis in mice.

Moshai EF, Wémeau-Stervinou L, Cigna N, Brayer S, Sommé JM, Crestani B, Mailleux AA.

Am J Respir Cell Mol Biol. 2014 Jul;51(1):11-25. doi: 10.1165/rcmb.2013-0154OC.

PMID:
24450438
19.

Role of Hedgehog-Gli1 signaling in the enhanced proliferation and differentiation of MG63 cells enabled by hierarchical micro-/nanotextured topography.

Lin Y, Huang Y, He J, Chen F, He Y, Zhang W.

Int J Nanomedicine. 2017 Apr 20;12:3267-3280. doi: 10.2147/IJN.S135045. eCollection 2017.

20.

Noncanonical regulation of the Hedgehog mediator GLI1 by c-MYC in Burkitt lymphoma.

Yoon JW, Gallant M, Lamm ML, Iannaccone S, Vieux KF, Proytcheva M, Hyjek E, Iannaccone P, Walterhouse D.

Mol Cancer Res. 2013 Jun;11(6):604-15. doi: 10.1158/1541-7786.MCR-12-0441. Epub 2013 Mar 22.

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