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Attenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp.

Nakayama M, Inoue T, Naito M, Nakayama K, Ohara N.

J Biol Chem. 2015 Feb 20;290(8):5190-202. doi: 10.1074/jbc.M114.591610. Epub 2015 Jan 6.


Noncanonical activation of β-catenin by Porphyromonas gingivalis.

Zhou Y, Sztukowska M, Wang Q, Inaba H, Potempa J, Scott DA, Wang H, Lamont RJ.

Infect Immun. 2015 Aug;83(8):3195-203. doi: 10.1128/IAI.00302-15. Epub 2015 Jun 1.


The roles of RgpB and Kgp in late onset gingipain activity in the vimA-defective mutant of Porphyromonas gingivalis W83.

Dou Y, Robles A, Roy F, Aruni AW, Sandberg L, Nothnagel E, Fletcher HM.

Mol Oral Microbiol. 2015 Oct;30(5):347-60. doi: 10.1111/omi.12098. Epub 2015 May 8.


Role of RgpA, RgpB, and Kgp proteinases in virulence of Porphyromonas gingivalis W50 in a murine lesion model.

O'Brien-Simpson NM, Paolini RA, Hoffmann B, Slakeski N, Dashper SG, Reynolds EC.

Infect Immun. 2001 Dec;69(12):7527-34.


Gingipain-dependent degradation of mammalian target of rapamycin pathway proteins by the periodontal pathogen Porphyromonas gingivalis during invasion.

Stafford P, Higham J, Pinnock A, Murdoch C, Douglas CW, Stafford GP, Lambert DW.

Mol Oral Microbiol. 2013 Oct;28(5):366-78. doi: 10.1111/omi.12030. Epub 2013 May 29.


Porphyromonas gingivalis gingipains: the molecular teeth of a microbial vampire.

O-Brien-Simpson NM, Veith PD, Dashper SG, Reynolds EC.

Curr Protein Pept Sci. 2003 Dec;4(6):409-26. Review.


The role of gingipains in the pathogenesis of periodontal disease.

Imamura T.

J Periodontol. 2003 Jan;74(1):111-8. Review.


Identification of a novel Porphyromonas gingivalis outer membrane protein, PG534, required for the production of active gingipains.

Saiki K, Konishi K.

FEMS Microbiol Lett. 2010 Sep 1;310(2):168-74. doi: 10.1111/j.1574-6968.2010.02059.x. Epub 2010 Jul 12.


Kgp and RgpB, but not RgpA, are important for Porphyromonas gingivalis virulence in the murine periodontitis model.

Pathirana RD, O'Brien-Simpson NM, Brammar GC, Slakeski N, Reynolds EC.

Infect Immun. 2007 Mar;75(3):1436-42. Epub 2007 Jan 12.


Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.

Pomowski A, Usón I, Nowakowska Z, Veillard F, Sztukowska MN, Guevara T, Goulas T, Mizgalska D, Nowak M, Potempa B, Huntington JA, Potempa J, Gomis-Rüth FX.

J Biol Chem. 2017 Apr 7;292(14):5724-5735. doi: 10.1074/jbc.M117.776724. Epub 2017 Feb 14.


Generation of lys-gingipain protease activity in Porphyromonas gingivalis W50 is independent of Arg-gingipain protease activities.

Aduse-Opoku J, Davies NN, Gallagher A, Hashim A, Evans HE, Rangarajan M, Slaney JM, Curtis MA.

Microbiology. 2000 Aug;146 ( Pt 8):1933-40.


Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis.

Palm E, Khalaf H, Bengtsson T.

Mol Oral Microbiol. 2015 Feb;30(1):74-85. doi: 10.1111/omi.12073. Epub 2014 Sep 19.


Gingipain-dependent augmentation by Porphyromonas gingivalis of phagocytosis of Tannerella forsythia.

Jung YJ, Jun HK, Choi BK.

Mol Oral Microbiol. 2016 Dec;31(6):457-471. doi: 10.1111/omi.12139. Epub 2015 Nov 13.


Gingipains inactivate a cell surface ligand on Porphyromonas gingivalis that induces TLR2-and TLR4-independent signaling.

Kishimoto M, Yoshimura A, Naito M, Okamoto K, Yamamoto K, Golenbock DT, Hara Y, Nakayama K.

Microbiol Immunol. 2006;50(4):315-25.


Gingipains from the Periodontal Pathogen Porphyromonas gingivalis Play a Significant Role in Regulation of Angiopoietin 1 and Angiopoietin 2 in Human Aortic Smooth Muscle Cells.

Zhang B, Khalaf H, Sirsjö A, Bengtsson T.

Infect Immun. 2015 Nov;83(11):4256-65. doi: 10.1128/IAI.00498-15. Epub 2015 Aug 17.


Contradictory roles of Porphyromonas gingivalis gingipains in caspase-1 activation.

Jung YJ, Jun HK, Choi BK.

Cell Microbiol. 2015 Sep;17(9):1304-19. doi: 10.1111/cmi.12435. Epub 2015 Apr 16.


Expression of Arg-Gingipain RgpB is required for correct glycosylation and stability of monomeric Arg-gingipain RgpA from Porphyromonas gingivalis W50.

Rangarajan M, Hashim A, Aduse-Opoku J, Paramonov N, Hounsell EF, Curtis MA.

Infect Immun. 2005 Aug;73(8):4864-78.


Antibody responses to Porphyromonas gingivalis infection in a murine abscess model--involvement of gingipains and responses to re-infection.

Yoneda M, Hirofuji T, Motooka N, Anan H, Hamachi T, Miura M, Ishihara Y, Maeda K.

J Periodontal Res. 2003 Dec;38(6):551-6.


Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner.

Glowczyk I, Wong A, Potempa B, Babyak O, Lech M, Lamont RJ, Potempa J, Koziel J.

Front Cell Infect Microbiol. 2017 Apr 27;7:140. doi: 10.3389/fcimb.2017.00140. eCollection 2017.

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