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Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.

Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A.

Science. 2015 Jan 2;347(6217):75-8. doi: 10.1126/science.1259724.


Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex.

Lyumkis D, Oliveira dos Passos D, Tahara EB, Webb K, Bennett EJ, Vinterbo S, Potter CS, Carragher B, Joazeiro CA.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15981-6. doi: 10.1073/pnas.1413882111. Epub 2014 Oct 27.


Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits.

Defenouillère Q, Zhang E, Namane A, Mouaikel J, Jacquier A, Fromont-Racine M.

J Biol Chem. 2016 Jun 3;291(23):12245-53. doi: 10.1074/jbc.M116.722264. Epub 2016 Apr 18.


Vms1p is a release factor for the ribosome-associated quality control complex.

Zurita Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J.

Nat Commun. 2018 Jun 6;9(1):2197. doi: 10.1038/s41467-018-04564-3.


CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides.

Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS.

Science. 2017 Jul 28;357(6349):414-417. doi: 10.1126/science.aam7787.


In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing.

Osuna BA, Howard CJ, Kc S, Frost A, Weinberg DE.

Elife. 2017 Jul 18;6. pii: e27949. doi: 10.7554/eLife.27949.


Failure of RQC machinery causes protein aggregation and proteotoxic stress.

Choe YJ, Park SH, Hassemer T, Körner R, Vincenz-Donnelly L, Hayer-Hartl M, Hartl FU.

Nature. 2016 Mar 10;531(7593):191-5. doi: 10.1038/nature16973. Epub 2016 Feb 29.


The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation.

Yonashiro R, Tahara EB, Bengtson MH, Khokhrina M, Lorenz H, Chen KC, Kigoshi-Tansho Y, Savas JN, Yates JR, Kay SA, Craig EA, Mogk A, Bukau B, Joazeiro CA.

Elife. 2016 Mar 4;5:e11794. doi: 10.7554/eLife.11794.


Modular assembly of the nucleolar pre-60S ribosomal subunit.

Sanghai ZA, Miller L, Molloy KR, Barandun J, Hunziker M, Chaker-Margot M, Wang J, Chait BT, Klinge S.

Nature. 2018 Apr 5;556(7699):126-129. doi: 10.1038/nature26156. Epub 2018 Mar 5.


The ribosome-bound quality control complex remains associated to aberrant peptides during their proteasomal targeting and interacts with Tom1 to limit protein aggregation.

Defenouillère Q, Namane A, Mouaikel J, Jacquier A, Fromont-Racine M.

Mol Biol Cell. 2017 May 1;28(9):1165-1176. doi: 10.1091/mbc.E16-10-0746. Epub 2017 Mar 15.


The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon.

von der Malsburg K, Shao S, Hegde RS.

Mol Biol Cell. 2015 Jun 15;26(12):2168-80. doi: 10.1091/mbc.E15-01-0040. Epub 2015 Apr 15.


Crystal structure of the eukaryotic ribosome.

Ben-Shem A, Jenner L, Yusupova G, Yusupov M.

Science. 2010 Nov 26;330(6008):1203-9. doi: 10.1126/science.1194294.


Interaction between 25S rRNA A loop and eukaryotic translation initiation factor 5B promotes subunit joining and ensures stringent AUG selection.

Hiraishi H, Shin BS, Udagawa T, Nemoto N, Chowdhury W, Graham J, Cox C, Reid M, Brown SJ, Asano K.

Mol Cell Biol. 2013 Sep;33(18):3540-8. doi: 10.1128/MCB.00771-13. Epub 2013 Jul 8.


Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation.

Greber BJ, Gerhardy S, Leitner A, Leibundgut M, Salem M, Boehringer D, Leulliot N, Aebersold R, Panse VG, Ban N.

Cell. 2016 Jan 14;164(1-2):91-102. doi: 10.1016/j.cell.2015.11.027. Epub 2015 Dec 17.


Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis.

Malyutin AG, Musalgaonkar S, Patchett S, Frank J, Johnson AW.

EMBO J. 2017 Apr 3;36(7):854-868. doi: 10.15252/embj.201696012. Epub 2017 Feb 8.


Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products.

Defenouillère Q, Yao Y, Mouaikel J, Namane A, Galopier A, Decourty L, Doyen A, Malabat C, Saveanu C, Jacquier A, Fromont-Racine M.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5046-51. doi: 10.1073/pnas.1221724110. Epub 2013 Mar 11.


Why Dom34 stimulates growth of cells with defects of 40S ribosomal subunit biosynthesis.

Bhattacharya A, McIntosh KB, Willis IM, Warner JR.

Mol Cell Biol. 2010 Dec;30(23):5562-71. doi: 10.1128/MCB.00618-10. Epub 2010 Sep 27.


Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation.

Sitron CS, Park JH, Brandman O.

RNA. 2017 May;23(5):798-810. doi: 10.1261/rna.060897.117. Epub 2017 Feb 21.


Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit.

Sengupta J, Bussiere C, Pallesen J, West M, Johnson AW, Frank J.

J Cell Biol. 2010 Jun 28;189(7):1079-86. doi: 10.1083/jcb.201001124.


The ribosome-bound quality control complex: from aberrant peptide clearance to proteostasis maintenance.

Defenouillère Q, Fromont-Racine M.

Curr Genet. 2017 Dec;63(6):997-1005. doi: 10.1007/s00294-017-0708-5. Epub 2017 May 20. Review.


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