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Items: 1 to 20 of 96

1.

Distinct gene expression responses of two anticonvulsant drugs in a novel human embryonic stem cell based neural differentiation assay protocol.

Schulpen SH, de Jong E, de la Fonteyne LJ, de Klerk A, Piersma AH.

Toxicol In Vitro. 2015 Apr;29(3):449-57. doi: 10.1016/j.tiv.2014.12.001. Epub 2014 Dec 15.

PMID:
25524013
2.

Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay.

Schulpen SH, Pennings JL, Piersma AH.

Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.

PMID:
25979313
3.

Comparison of gene expression regulation in mouse- and human embryonic stem cell assays during neural differentiation and in response to valproic acid exposure.

Schulpen SH, Theunissen PT, Pennings JL, Piersma AH.

Reprod Toxicol. 2015 Aug 15;56:77-86. doi: 10.1016/j.reprotox.2015.06.043. Epub 2015 Jun 11.

PMID:
26072468
4.

Estimation of the embryotoxic effect of CBZ using an ES cell differentiation system.

Murabe M, Yamauchi J, Fujiwara Y, Miyamoto Y, Hiroyama M, Sanbe A, Tanoue A.

Biochem Biophys Res Commun. 2007 May 11;356(3):739-44. Epub 2007 Mar 19.

PMID:
17382902
5.

Effects of valproic acid on gene expression during human embryonic stem cell differentiation into neurons.

Ehashi T, Suzuki N, Ando S, Sumida K, Saito K.

J Toxicol Sci. 2014 Jun;39(3):383-90.

6.

Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn).

Theunissen PT, Robinson JF, Pennings JL, de Jong E, Claessen SM, Kleinjans JC, Piersma AH.

Toxicol Sci. 2012 Feb;125(2):430-8. doi: 10.1093/toxsci/kfr293. Epub 2011 Nov 1.

PMID:
22045034
7.

Look-alikes may not act alike: Gene expression regulation and cell-type-specific responses of three valproic acid analogues in the neural embryonic stem cell test (ESTn).

de Leeuw VC, Hessel EVS, Piersma AH.

Toxicol Lett. 2019 Mar 15;303:28-37. doi: 10.1016/j.toxlet.2018.12.005. Epub 2018 Dec 19.

PMID:
30578912
8.

Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells.

Theunissen PT, Pennings JL, Robinson JF, Claessen SM, Kleinjans JC, Piersma AH.

Toxicol Sci. 2011 Aug;122(2):437-47. doi: 10.1093/toxsci/kfr134. Epub 2011 May 25.

PMID:
21613230
9.

Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells.

Jergil M, Forsberg M, Salter H, Stockling K, Gustafson AL, Dencker L, Stigson M.

Toxicol Sci. 2011 Jun;121(2):328-42. doi: 10.1093/toxsci/kfr070. Epub 2011 Apr 6.

PMID:
21427059
10.

Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn).

Theunissen PT, Robinson JF, Pennings JL, van Herwijnen MH, Kleinjans JC, Piersma AH.

Toxicol Appl Pharmacol. 2012 Aug 1;262(3):330-40. doi: 10.1016/j.taap.2012.05.011. Epub 2012 May 23.

PMID:
22634333
12.

c-Jun Amino-Terminal Kinase is Involved in Valproic Acid-Mediated Neuronal Differentiation of Mouse Embryonic NSCs and Neurite Outgrowth of NSC-Derived Neurons.

Lu L, Zhou H, Pan B, Li X, Fu Z, Liu J, Shi Z, Chu T, Wei Z, Ning G, Feng S.

Neurochem Res. 2017 Apr;42(4):1254-1266. doi: 10.1007/s11064-016-2167-7. Epub 2017 Mar 21.

13.

An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. II. Testing of compounds.

Festag M, Viertel B, Steinberg P, Sehner C.

Toxicol In Vitro. 2007 Dec;21(8):1631-40. Epub 2007 Jul 18.

PMID:
17719739
14.

Potency ranking of valproic acid analogues as to inhibition of cardiac differentiation of embryonic stem cells in comparison to their in vivo embryotoxicity.

de Jong E, Doedée AM, Reis-Fernandes MA, Nau H, Piersma AH.

Reprod Toxicol. 2011 May;31(4):375-82. doi: 10.1016/j.reprotox.2010.11.012. Epub 2010 Nov 27. Review.

PMID:
21115111
15.

A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons.

Fujiki R, Sato A, Fujitani M, Yamashita T.

Cell Death Dis. 2013 Jun 20;4:e677. doi: 10.1038/cddis.2013.205.

16.

An abbreviated protocol for multilineage neural differentiation of murine embryonic stem cells and its perturbation by methyl mercury.

Theunissen PT, Schulpen SH, van Dartel DA, Hermsen SA, van Schooten FJ, Piersma AH.

Reprod Toxicol. 2010 Jul;29(4):383-92. doi: 10.1016/j.reprotox.2010.04.003. Epub 2010 Apr 20.

PMID:
20412851
17.

Molecular multiple endpoint embryonic stem cell test--a possible approach to test for the teratogenic potential of compounds.

zur Nieden NI, Kempka G, Ahr HJ.

Toxicol Appl Pharmacol. 2004 Feb 1;194(3):257-69.

PMID:
14761682
18.

A comparative transcriptomic study on the effects of valproic acid on two different hESCs lines in a neural teratogenicity test system.

Colleoni S, Galli C, Gaspar JA, Meganathan K, Jagtap S, Hescheler J, Zagoura D, Bremer S, Sachinidis A, Lazzari G.

Toxicol Lett. 2014 Nov 18;231(1):38-44. doi: 10.1016/j.toxlet.2014.08.023. Epub 2014 Sep 2.

PMID:
25192806
19.

A novel embryotoxic estimation method of VPA using ES cells differentiation system.

Murabe M, Yamauchi J, Fujiwara Y, Hiroyama M, Sanbe A, Tanoue A.

Biochem Biophys Res Commun. 2007 Jan 5;352(1):164-9. Epub 2006 Nov 13.

PMID:
17112465
20.

The embryonic stem cell test as tool to assess structure-dependent teratogenicity: the case of valproic acid.

Riebeling C, Pirow R, Becker K, Buesen R, Eikel D, Kaltenhäuser J, Meyer F, Nau H, Slawik B, Visan A, Volland J, Spielmann H, Luch A, Seiler A.

Toxicol Sci. 2011 Apr;120(2):360-70. doi: 10.1093/toxsci/kfr001. Epub 2011 Jan 11.

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