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Items: 1 to 20 of 246

1.

Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.

Anandhan A, Rodriguez-Rocha H, Bohovych I, Griggs AM, Zavala-Flores L, Reyes-Reyes EM, Seravalli J, Stanciu LA, Lee J, Rochet JC, Khalimonchuk O, Franco R.

Neurobiol Dis. 2015 Sep;81:76-92. doi: 10.1016/j.nbd.2014.11.018. Epub 2014 Dec 8.

2.

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.

Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, Ross CA.

Hum Mol Genet. 2005 Dec 15;14(24):3801-11. Epub 2005 Oct 20.

PMID:
16239241
3.

Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions.

Anandhan A, Lei S, Levytskyy R, Pappa A, Panayiotidis MI, Cerny RL, Khalimonchuk O, Powers R, Franco R.

Mol Neurobiol. 2017 Jul;54(5):3825-3842. doi: 10.1007/s12035-016-9906-2. Epub 2016 Jun 20.

4.

Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.

Navarro-Yepes J, Anandhan A, Bradley E, Bohovych I, Yarabe B, de Jong A, Ovaa H, Zhou Y, Khalimonchuk O, Quintanilla-Vega B, Franco R.

Mol Neurobiol. 2016 Oct;53(8):5229-51. doi: 10.1007/s12035-015-9414-9. Epub 2015 Sep 26.

5.

TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopaminergic cells.

Wang MX, Cheng XY, Jin M, Cao YL, Yang YP, Wang JD, Li Q, Wang F, Hu LF, Liu CF.

Exp Neurol. 2015 Sep;271:112-21. doi: 10.1016/j.expneurol.2015.05.008. Epub 2015 May 19.

PMID:
26001614
6.

α-Synuclein Enhances Cadmium Uptake and Neurotoxicity via Oxidative Stress and Caspase Activated Cell Death Mechanisms in a Dopaminergic Cell Model of Parkinson's Disease.

Chong W, Jiménez J, McIIvin M, Saito MA, Kwakye GF.

Neurotox Res. 2017 Aug;32(2):231-246. doi: 10.1007/s12640-017-9725-x. Epub 2017 Mar 28.

PMID:
28353032
7.

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.

Butler EK, Voigt A, Lutz AK, Toegel JP, Gerhardt E, Karsten P, Falkenburger B, Reinartz A, Winklhofer KF, Schulz JB.

PLoS Genet. 2012 Feb;8(2):e1002488. doi: 10.1371/journal.pgen.1002488. Epub 2012 Feb 2.

8.

A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.

Luo J, Sun L, Lin X, Liu G, Yu J, Parisiadou L, Xie C, Ding J, Cai H.

Hum Mol Genet. 2014 Dec 15;23(24):6567-74. doi: 10.1093/hmg/ddu377. Epub 2014 Jul 22.

9.

Thioredoxin-interacting protein induced α-synuclein accumulation via inhibition of autophagic flux: Implications for Parkinson's disease.

Su CJ, Feng Y, Liu TT, Liu X, Bao JJ, Shi AM, Hu DM, Liu T, Yu YL.

CNS Neurosci Ther. 2017 Sep;23(9):717-723. doi: 10.1111/cns.12721. Epub 2017 Jul 29.

PMID:
28755477
10.

Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate α-Synuclein Disrupted Gene Expression.

Volakakis N, Tiklova K, Decressac M, Papathanou M, Mattsson B, Gillberg L, Nobre A, Björklund A, Perlmann T.

J Neurosci. 2015 Oct 21;35(42):14370-85. doi: 10.1523/JNEUROSCI.1155-15.2015.

11.

alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress.

Sharma N, Brandis KA, Herrera SK, Johnson BE, Vaidya T, Shrestha R, Debburman SK.

J Mol Neurosci. 2006;28(2):161-78.

PMID:
16679556
12.

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.

Decressac M, Mattsson B, Lundblad M, Weikop P, Björklund A.

Neurobiol Dis. 2012 Mar;45(3):939-53. doi: 10.1016/j.nbd.2011.12.013. Epub 2011 Dec 11.

PMID:
22182688
14.

Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons.

Caudal D, Alvarsson A, Björklund A, Svenningsson P.

Exp Neurol. 2015 Nov;273:243-52. doi: 10.1016/j.expneurol.2015.09.002. Epub 2015 Sep 9.

PMID:
26363495
15.

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.

Tanaka Y, Engelender S, Igarashi S, Rao RK, Wanner T, Tanzi RE, Sawa A, L Dawson V, Dawson TM, Ross CA.

Hum Mol Genet. 2001 Apr 15;10(9):919-26.

PMID:
11309365
16.

DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity.

Zhou W, Freed CR.

J Biol Chem. 2005 Dec 30;280(52):43150-8. Epub 2005 Oct 14.

17.

Beclin1 and HMGB1 ameliorate the α-synuclein-mediated autophagy inhibition in PC12 cells.

Wang K, Huang J, Xie W, Huang L, Zhong C, Chen Z.

Diagn Pathol. 2016 Jan 29;11:15. doi: 10.1186/s13000-016-0459-5.

18.

Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells.

Bisaglia M, Greggio E, Maric D, Miller DW, Cookson MR, Bubacco L.

BMC Neurosci. 2010 Mar 25;11:41. doi: 10.1186/1471-2202-11-41.

19.

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

Zhou W, Hurlbert MS, Schaack J, Prasad KN, Freed CR.

Brain Res. 2000 Jun 2;866(1-2):33-43.

PMID:
10825478
20.

Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease.

Lasser-Katz E, Simchovitz A, Chiu WH, Oertel WH, Sharon R, Soreq H, Roeper J, Goldberg JA.

J Neurosci. 2017 Jan 4;37(1):47-57. doi: 10.1523/JNEUROSCI.1079-16.2016.

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