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Items: 1 to 20 of 115

1.

Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorγT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung.

Balabko L, Andreev K, Burmann N, Schubert M, Mathews M, Trufa DI, Reppert S, Rau T, Schicht M, Sirbu H, Hartmann A, Finotto S.

Sci Rep. 2014 Dec 10;4:7396. doi: 10.1038/srep07396.

2.

Imbalance in the Th17/Treg and cytokine environment in peripheral blood of patients with adenocarcinoma and squamous cell carcinoma.

Zhao L, Yang J, Wang HP, Liu RY.

Med Oncol. 2013 Mar;30(1):461. doi: 10.1007/s12032-013-0461-7. Epub 2013 Jan 20.

PMID:
23335103
3.

Histone deacetylase inhibitors modulate interleukin 6-dependent CD4+ T cell polarization in vitro and in vivo.

Glauben R, Sonnenberg E, Wetzel M, Mascagni P, Siegmund B.

J Biol Chem. 2014 Feb 28;289(9):6142-51. doi: 10.1074/jbc.M113.517599. Epub 2014 Jan 13.

4.

Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer.

Punkenburg E, Vogler T, Büttner M, Amann K, Waldner M, Atreya R, Abendroth B, Mudter J, Merkel S, Gallmeier E, Rose-John S, Neurath MF, Hildner K.

Gut. 2016 Jul;65(7):1139-50. doi: 10.1136/gutjnl-2014-308227. Epub 2015 Apr 2.

PMID:
25838550
5.

Dysregulated development of IL-17- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt.

Wichner K, Stauss D, Kampfrath B, Krüger K, Müller G, Rehm A, Lipp M, Höpken UE.

FASEB J. 2016 Feb;30(2):761-74. doi: 10.1096/fj.15-274001. Epub 2015 Oct 23.

PMID:
26499265
6.

An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.

Massoud AH, Charbonnier LM, Lopez D, Pellegrini M, Phipatanakul W, Chatila TA.

Nat Med. 2016 Sep;22(9):1013-22. doi: 10.1038/nm.4147. Epub 2016 Aug 1.

7.

AT-rich-interactive domain-containing protein 5A functions as a negative regulator of retinoic acid receptor-related orphan nuclear receptor γt-induced Th17 cell differentiation.

Saito Y, Kagami S, Sanayama Y, Ikeda K, Suto A, Kashiwakuma D, Furuta S, Iwamoto I, Nonaka K, Ohara O, Nakajima H.

Arthritis Rheumatol. 2014 May;66(5):1185-94. doi: 10.1002/art.38324.

8.

The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell-driven immune responses in the setting of allergic asthma.

Übel C, Sopel N, Graser A, Hildner K, Reinhardt C, Zimmermann T, Rieker RJ, Maier A, Neurath MF, Murphy KM, Finotto S.

J Allergy Clin Immunol. 2014 Jan;133(1):198-206.e1-9. doi: 10.1016/j.jaci.2013.09.049. Epub 2013 Nov 28.

PMID:
24290279
9.

IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy.

Koch S, Mousset S, Graser A, Reppert S, Übel C, Reinhardt C, Zimmermann T, Rieker R, Lehr HA, Finotto S.

Sci Rep. 2013;3:1754. doi: 10.1038/srep01754.

10.

Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.

Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Galle PR, Neurath MF.

Int Immunol. 2007 Jun;19(6):685-93. Epub 2007 May 11.

PMID:
17496315
11.

IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis.

Yamashita T, Iwakura T, Matsui K, Kawaguchi H, Obana M, Hayama A, Maeda M, Izumi Y, Komuro I, Ohsugi Y, Fujimoto M, Naka T, Kishimoto T, Nakayama H, Fujio Y.

Cardiovasc Res. 2011 Sep 1;91(4):640-8. doi: 10.1093/cvr/cvr148. Epub 2011 May 27.

PMID:
21622681
12.

CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response.

Betts BC, Sagatys EM, Veerapathran A, Lloyd MC, Beato F, Lawrence HR, Yue B, Kim J, Sebti SM, Anasetti C, Pidala J.

J Leukoc Biol. 2015 Apr;97(4):807-19. doi: 10.1189/jlb.5A1114-532RR. Epub 2015 Feb 6.

13.

[Role of Foxp3/Treg and RORγt/Th17 cell imbalance in rat model of chronic obstructive pulmonary disease].

Wang C, Liu X, Peng Q, Fang L, Wang C, Li Z.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014 Dec;26(12):860-4. doi: 10.3760/cma.j.issn.2095-4352.2014.12.003. Chinese.

14.

A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer.

Reppert S, Boross I, Koslowski M, Türeci Ö, Koch S, Lehr HA, Finotto S.

Nat Commun. 2011 Dec 20;2:600. doi: 10.1038/ncomms1609.

PMID:
22186896
15.

FOXP3 and RORγt: transcriptional regulation of Treg and Th17.

Chen Z, Lin F, Gao Y, Li Z, Zhang J, Xing Y, Deng Z, Yao Z, Tsun A, Li B.

Int Immunopharmacol. 2011 May;11(5):536-42. doi: 10.1016/j.intimp.2010.11.008. Epub 2010 Nov 23. Review.

PMID:
21081189
16.

Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma.

Shinriki S, Jono H, Ota K, Ueda M, Kudo M, Ota T, Oike Y, Endo M, Ibusuki M, Hiraki A, Nakayama H, Yoshitake Y, Shinohara M, Ando Y.

Clin Cancer Res. 2009 Sep 1;15(17):5426-34. doi: 10.1158/1078-0432.CCR-09-0287. Epub 2009 Aug 25.

17.

Treg/Th17 imbalance in malignant pleural effusion partially predicts poor prognosis.

Yang G, Li H, Yao Y, Xu F, Bao Z, Zhou J.

Oncol Rep. 2015 Jan;33(1):478-84. doi: 10.3892/or.2014.3576. Epub 2014 Oct 30.

PMID:
25371165
18.

IL-12 inhibits the TGF-β-dependent T cell developmental programs and skews the TGF-β-induced differentiation into a Th1-like direction.

Prochazkova J, Pokorna K, Holan V.

Immunobiology. 2012 Jan;217(1):74-82. doi: 10.1016/j.imbio.2011.07.032. Epub 2011 Aug 5.

PMID:
21903294
19.

pSTAT3 Levels Have Divergent Expression Patterns and Associations with Survival in Squamous Cell Carcinoma and Adenocarcinoma of the Oesophagus.

O' Sullivan KE, Michielsen AJ, O' Regan E, Cathcart MC, Moore G, Breen E, Segurado R, Reynolds JV, Lysaght J, O' Sullivan J.

Int J Mol Sci. 2018 Jun 10;19(6). pii: E1720. doi: 10.3390/ijms19061720.

20.

Expression of Th17-related genes in PHA/IL-2-activated human T cells by Fas signaling via caspase-1- and Stat3-dependent pathway.

Su CC, Lin HC, Lin YP, Shan YS, Yang BC.

Cell Immunol. 2013 Feb;281(2):101-10. doi: 10.1016/j.cellimm.2013.03.002. Epub 2013 Mar 28.

PMID:
23590971

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