Similar articles for PMID: 25377078

Year	Number of Results
2002	1
2003	2
2004	1
2005	3
2006	5
2007	3
2008	7
2009	4
2010	11
2011	11
2012	13
2013	8
2014	12
2015	14
2016	10
2017	8
2018	7
2019	4
2020	6
2021	10
2022	7
2023	1
2024	0

1

Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.

Kikuchi E, Mori T, Zeniya M, Isobe K, Ishigami-Yuasa M, Fujii S, Kagechika H, Ishihara T, Mizushima T, Sasaki S, Sohara E, Rai T, Uchida S. Kikuchi E, et al. J Am Soc Nephrol. 2015 Jul;26(7):1525-36. doi: 10.1681/ASN.2014060560. Epub 2014 Nov 5. J Am Soc Nephrol. 2015. PMID: 25377078 Free PMC article.

2

[WNK-SPAK-SLC12A signal cascade is a new therapeutic target for hypertension].

Kikuchi E, Mori T, Uchida S. Kikuchi E, et al. Nihon Rinsho. 2015 Sep;73(9):1597-605. Nihon Rinsho. 2015. PMID: 26394527 Review. Japanese.

3

Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.

Lin SH, Yu IS, Jiang ST, Lin SW, Chu P, Chen A, Sytwu HK, Sohara E, Uchida S, Sasaki S, Yang SS. Lin SH, et al. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17538-43. doi: 10.1073/pnas.1107452108. Epub 2011 Oct 4. Proc Natl Acad Sci U S A. 2011. PMID: 21972418 Free PMC article.

4

Cotransporters, WNKs and hypertension: an update.

Flatman PW. Flatman PW. Curr Opin Nephrol Hypertens. 2008 Mar;17(2):186-92. doi: 10.1097/MNH.0b013e3282f5244e. Curr Opin Nephrol Hypertens. 2008. PMID: 18277153 Review.

5

Development of WNK signaling inhibitors as a new class of antihypertensive drugs.

Ishigami-Yuasa M, Watanabe Y, Mori T, Masuno H, Fujii S, Kikuchi E, Uchida S, Kagechika H. Ishigami-Yuasa M, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3845-3852. doi: 10.1016/j.bmc.2017.05.034. Epub 2017 May 19. Bioorg Med Chem. 2017. PMID: 28566208

6

Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.

Mori T, Kikuchi E, Watanabe Y, Fujii S, Ishigami-Yuasa M, Kagechika H, Sohara E, Rai T, Sasaki S, Uchida S. Mori T, et al. Biochem J. 2013 Nov 1;455(3):339-45. doi: 10.1042/BJ20130597. Biochem J. 2013. PMID: 23981180

7

SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction.

Yang SS, Lo YF, Wu CC, Lin SW, Yeh CJ, Chu P, Sytwu HK, Uchida S, Sasaki S, Lin SH. Yang SS, et al. J Am Soc Nephrol. 2010 Nov;21(11):1868-77. doi: 10.1681/ASN.2009121295. Epub 2010 Sep 2. J Am Soc Nephrol. 2010. PMID: 20813865 Free PMC article.

8

Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents.

Fujii S, Kikuchi E, Suzuyama H, Watanabe Y, Ishigami-Yuasa M, Masuno H, Mori T, Isobe K, Uchida S, Kagechika H. Fujii S, et al. ChemMedChem. 2021 Sep 16;16(18):2817-2822. doi: 10.1002/cmdc.202100273. Epub 2021 Jul 2. ChemMedChem. 2021. PMID: 34109743

9

Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.

Nishida H, Sohara E, Nomura N, Chiga M, Alessi DR, Rai T, Sasaki S, Uchida S. Nishida H, et al. Hypertension. 2012 Oct;60(4):981-90. doi: 10.1161/HYPERTENSIONAHA.112.201509. Epub 2012 Sep 4. Hypertension. 2012. PMID: 22949526 Free PMC article.

10

Role of the WNK-activated SPAK kinase in regulating blood pressure.

Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanović S, Jovanović A, O'Shaughnessy KM, Alessi DR. Rafiqi FH, et al. EMBO Mol Med. 2010 Feb;2(2):63-75. doi: 10.1002/emmm.200900058. EMBO Mol Med. 2010. PMID: 20091762 Free PMC article.

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