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Items: 1 to 20 of 61

1.

Nonstructural protein 1 (NS1)-mediated inhibition of c-Abl results in acute lung injury and priming for bacterial co-infections: insights into 1918 H1N1 pandemic?

Hrincius ER, Liedmann S, Finkelstein D, Vogel P, Gansebom S, Ehrhardt C, Ludwig S, Hains DS, Webby R, McCullers JA.

J Infect Dis. 2015 May 1;211(9):1418-28. doi: 10.1093/infdis/jiu609. Epub 2014 Nov 2.

PMID:
25367299
2.

Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses.

Clark AM, Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML.

J Virol. 2017 Aug 10;91(17). pii: e00721-17. doi: 10.1128/JVI.00721-17. Print 2017 Sep 1.

3.

Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses.

Ozawa M, Basnet S, Burley LM, Neumann G, Hatta M, Kawaoka Y.

J Virol. 2011 May;85(9):4596-601. doi: 10.1128/JVI.00029-11. Epub 2011 Feb 16.

4.

Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translation.

Kainov DE, Müller KH, Theisen LL, Anastasina M, Kaloinen M, Muller CP.

J Biol Chem. 2011 Mar 4;286(9):7239-47. doi: 10.1074/jbc.M110.203489. Epub 2010 Dec 16.

5.

Avian influenza viruses inhibit the major cellular signalling integrator c-Abl.

Hrincius ER, Liedmann S, Anhlan D, Wolff T, Ludwig S, Ehrhardt C.

Cell Microbiol. 2014 Dec;16(12):1854-74. doi: 10.1111/cmi.12332. Epub 2014 Aug 26.

PMID:
25052580
6.

Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus.

Nogales A, Rodriguez L, DeDiego ML, Topham DJ, Martínez-Sobrido L.

J Virol. 2017 Aug 10;91(17). pii: e00720-17. doi: 10.1128/JVI.00720-17. Print 2017 Sep 1.

7.

Effects of the C-terminal truncation in NS1 protein of the 2009 pandemic H1N1 influenza virus on host gene expression.

Tu J, Guo J, Zhang A, Zhang W, Zhao Z, Zhou H, Liu C, Chen H, Jin M.

PLoS One. 2011;6(10):e26175. doi: 10.1371/journal.pone.0026175. Epub 2011 Oct 12.

8.

Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein.

Zielecki F, Semmler I, Kalthoff D, Voss D, Mauel S, Gruber AD, Beer M, Wolff T.

J Virol. 2010 Oct;84(20):10708-18. doi: 10.1128/JVI.00610-10. Epub 2010 Aug 4.

9.

Mutations in the C-terminal tail of NS1 protein facilitate the replication of classical swine H1N1 influenza A virus in mice.

Wang J, Qi X, Lu C.

Folia Microbiol (Praha). 2012 May;57(3):169-75. doi: 10.1007/s12223-012-0110-0. Epub 2012 Mar 20.

PMID:
22430886
10.

G45R on nonstructural protein 1 of influenza A virus contributes to virulence by increasing the expression of proinflammatory cytokines in mice.

Kaewborisuth C, Kaplan B, Zanin M, Finkelstein D, Webby RJ, Lekcharoensuk P.

Arch Virol. 2017 Jan;162(1):45-55. doi: 10.1007/s00705-016-3072-8. Epub 2016 Sep 23.

PMID:
27664027
11.

Synergism of co-mutation of two amino acid residues in NS1 protein increases the pathogenicity of influenza virus in mice.

Pu J, Wang J, Zhang Y, Fu G, Bi Y, Sun Y, Liu J.

Virus Res. 2010 Aug;151(2):200-4. doi: 10.1016/j.virusres.2010.05.007. Epub 2010 May 28.

PMID:
20546807
12.

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

Heikkinen LS, Kazlauskas A, Melén K, Wagner R, Ziegler T, Julkunen I, Saksela K.

J Biol Chem. 2008 Feb 29;283(9):5719-27. doi: 10.1074/jbc.M707195200. Epub 2007 Dec 28.

13.

Inhibition of host innate immune responses and pathogenicity of recombinant Newcastle disease viruses expressing NS1 genes of influenza A viruses.

Kim SH, Samal SK.

J Gen Virol. 2010 Aug;91(Pt 8):1996-2001. doi: 10.1099/vir.0.021766-0. Epub 2010 Apr 21.

PMID:
20410312
14.

Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene.

Kochs G, Martínez-Sobrido L, Lienenklaus S, Weiss S, García-Sastre A, Staeheli P.

J Gen Virol. 2009 Dec;90(Pt 12):2990-4. doi: 10.1099/vir.0.015727-0. Epub 2009 Sep 2.

15.

Virulence and genetic compatibility of polymerase reassortant viruses derived from the pandemic (H1N1) 2009 influenza virus and circulating influenza A viruses.

Song MS, Pascua PN, Lee JH, Baek YH, Park KJ, Kwon HI, Park SJ, Kim CJ, Kim H, Webby RJ, Webster RG, Choi YK.

J Virol. 2011 Jul;85(13):6275-86. doi: 10.1128/JVI.02125-10. Epub 2011 Apr 20.

16.

Shortening the unstructured, interdomain region of the non-structural protein NS1 of an avian H1N1 influenza virus increases its replication and pathogenicity in chickens.

Trapp S, Soubieux D, Marty H, Esnault E, Hoffmann TW, Chandenier M, Lion A, Kut E, Quéré P, Larcher T, Ledevin M, Munier S, Naffakh N, Marc D.

J Gen Virol. 2014 Jun;95(Pt 6):1233-43. doi: 10.1099/vir.0.063776-0. Epub 2014 Apr 2.

PMID:
24694396
17.

Effect on virulence and pathogenicity of H5N1 influenza A virus through truncations of NS1 eIF4GI binding domain.

Zhou H, Zhu J, Tu J, Zou W, Hu Y, Yu Z, Yin W, Li Y, Zhang A, Wu Y, Yu Z, Chen H, Jin M.

J Infect Dis. 2010 Nov 1;202(9):1338-46. doi: 10.1086/656536.

PMID:
20854176
18.

Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses.

Lee J, Yu H, Li Y, Ma J, Lang Y, Duff M, Henningson J, Liu Q, Li Y, Nagy A, Bawa B, Li Z, Tong G, Richt JA, Ma W.

Virology. 2017 Apr;504:25-35. doi: 10.1016/j.virol.2017.01.015. Epub 2017 Jan 29.

19.

[Transmissibility and pathogenicity of influenza viruses].

Horimoto T, Yamada S, Kawaoka Y.

Nihon Rinsho. 2010 Sep;68(9):1616-23. Review. Japanese.

PMID:
20845737
20.

Phenotypic differences in virulence and immune response in closely related clinical isolates of influenza A 2009 H1N1 pandemic viruses in mice.

Camp JV, Chu YK, Chung DH, McAllister RC, Adcock RS, Gerlach RL, Wiemken TL, Peyrani P, Ramirez JA, Summersgill JT, Jonsson CB.

PLoS One. 2013;8(2):e56602. doi: 10.1371/journal.pone.0056602. Epub 2013 Feb 18.

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