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Items: 1 to 20 of 136

1.

Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation.

Jolly L, Stavrou A, Vanderstoken G, Meliopoulos VA, Habgood A, Tatler AL, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli MR, Schultz-Cherry S, Jenkins G.

J Biol Chem. 2014 Dec 19;289(51):35246-63. doi: 10.1074/jbc.M114.582262. Epub 2014 Oct 22.

2.

Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.

Tatler AL, Goodwin AT, Gbolahan O, Saini G, Porte J, John AE, Clifford RL, Violette SM, Weinreb PH, Parfrey H, Wolters PJ, Gauldie J, Kolb M, Jenkins G.

PLoS One. 2016 Aug 5;11(8):e0158047. doi: 10.1371/journal.pone.0158047. eCollection 2016.

3.

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

Xu MY, Porte J, Knox AJ, Weinreb PH, Maher TM, Violette SM, McAnulty RJ, Sheppard D, Jenkins G.

Am J Pathol. 2009 Apr;174(4):1264-79. doi: 10.2353/ajpath.2009.080160. Epub 2009 Jan 15.

4.

Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.

Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L.

Am J Pathol. 2008 Apr;172(4):1127-40. doi: 10.2353/ajpath.2008.070448. Epub 2008 Mar 18.

5.

Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis.

Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L726-35. doi: 10.1152/ajplung.00357.2013. Epub 2014 Feb 7.

6.

Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression.

Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman SL, Schuppan D.

Gastroenterology. 2008 Aug;135(2):660-70. doi: 10.1053/j.gastro.2008.04.009. Epub 2008 Apr 16.

7.

Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.

Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF.

Circ Res. 2008 Apr 11;102(7):804-12. doi: 10.1161/CIRCRESAHA.107.161067. Epub 2008 Feb 14.

8.

Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-β activation by epithelial cells and fibroblasts.

Sheppard D.

Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S21-3. doi: 10.1513/AnnalsATS.201406-245MG. Review.

9.

Preclinical SPECT/CT imaging of αvβ6 integrins for molecular stratification of idiopathic pulmonary fibrosis.

John AE, Luckett JC, Tatler AL, Awais RO, Desai A, Habgood A, Ludbrook S, Blanchard AD, Perkins AC, Jenkins RG, Marshall JF.

J Nucl Med. 2013 Dec;54(12):2146-52. doi: 10.2967/jnumed.113.120592. Epub 2013 Oct 28.

10.

γ-Herpes virus-68, but not Pseudomonas aeruginosa or influenza A (H1N1), exacerbates established murine lung fibrosis.

Ashley SL, Jegal Y, Moore TA, van Dyk LF, Laouar Y, Moore BB.

Am J Physiol Lung Cell Mol Physiol. 2014 Aug 1;307(3):L219-30. doi: 10.1152/ajplung.00300.2013. Epub 2014 May 30.

11.

Role of alphavbeta6 integrin in acute biliary fibrosis.

Wang B, Dolinski BM, Kikuchi N, Leone DR, Peters MG, Weinreb PH, Violette SM, Bissell DM.

Hepatology. 2007 Nov;46(5):1404-12.

12.

Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-β release in lung epithelial cells.

Roberson EC, Tully JE, Guala AS, Reiss JN, Godburn KE, Pociask DA, Alcorn JF, Riches DW, Dienz O, Janssen-Heininger YM, Anathy V.

Am J Respir Cell Mol Biol. 2012 May;46(5):573-81. doi: 10.1165/rcmb.2010-0460OC. Epub 2011 Jul 28.

13.

Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence.

Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA, Dickinson S, Edwards DR, Pennington CJ, Sestak I, Cuzick J, Marshall JF, Hart IR, Jones JL.

Clin Cancer Res. 2014 Jan 15;20(2):344-57. doi: 10.1158/1078-0432.CCR-13-1504. Epub 2013 Oct 22.

14.

Interleukin-1β Promotes Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β Activation.

Wang J, Bao L, Yu B, Liu Z, Han W, Deng C, Guo C.

Cell Physiol Biochem. 2015;36(6):2198-216. doi: 10.1159/000430185. Epub 2015 Jul 24.

15.

Localization of ανβ6 integrin-TGF-β1/Smad3, mTOR and PPARγ in experimental colorectal fibrosis.

Latella G, Vetuschi A, Sferra R, Speca S, Gaudio E.

Eur J Histochem. 2013 Dec 4;57(4):e40. doi: 10.4081/ejh.2013.e40.

16.

Integrin-mediated activation of latent transforming growth factor beta.

Sheppard D.

Cancer Metastasis Rev. 2005 Sep;24(3):395-402. Review.

PMID:
16258727
17.

IL-6 ameliorates acute lung injury in influenza virus infection.

Yang ML, Wang CT, Yang SJ, Leu CH, Chen SH, Wu CL, Shiau AL.

Sci Rep. 2017 Mar 6;7:43829. doi: 10.1038/srep43829.

18.

Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice.

Pi L, Robinson PM, Jorgensen M, Oh SH, Brown AR, Weinreb PH, Trinh TL, Yianni P, Liu C, Leask A, Violette SM, Scott EW, Schultz GS, Petersen BE.

Hepatology. 2015 Feb;61(2):678-91. doi: 10.1002/hep.27425.

19.

Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression.

Tatler AL, Habgood A, Porte J, John AE, Stavrou A, Hodge E, Kerama-Likoko C, Violette SM, Weinreb PH, Knox AJ, Laurent G, Parfrey H, Wolters PJ, Wallace W, Alberti S, Nordheim A, Jenkins G.

J Biol Chem. 2016 Apr 29;291(18):9540-53. doi: 10.1074/jbc.M115.692368. Epub 2016 Feb 9.

20.

E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin αvβ6 and maintained through TGFβ signalling.

Eberlein C, Rooney C, Ross SJ, Farren M, Weir HM, Barry ST.

Oncogene. 2015 Feb 5;34(6):704-16. doi: 10.1038/onc.2013.600. Epub 2014 Feb 3.

PMID:
24488011

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