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Items: 1 to 20 of 84

1.

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS.

Cell. 2014 Oct 23;159(3):647-61. doi: 10.1016/j.cell.2014.09.029. Epub 2014 Oct 9.

2.

CRISPR Technology for Genome Activation and Repression in Mammalian Cells.

Du D, Qi LS.

Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.prot090175. doi: 10.1101/pdb.prot090175.

PMID:
26729910
3.

Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation.

Dominguez AA, Lim WA, Qi LS.

Nat Rev Mol Cell Biol. 2016 Jan;17(1):5-15. doi: 10.1038/nrm.2015.2. Epub 2015 Dec 16. Review.

4.

CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine.

Kampmann M.

ACS Chem Biol. 2018 Feb 16;13(2):406-416. doi: 10.1021/acschembio.7b00657. Epub 2017 Oct 24.

PMID:
29035510
5.

The New State of the Art: Cas9 for Gene Activation and Repression.

La Russa MF, Qi LS.

Mol Cell Biol. 2015 Nov;35(22):3800-9. doi: 10.1128/MCB.00512-15. Epub 2015 Sep 14. Review.

6.

Targeted Transcriptional Repression in Bacteria Using CRISPR Interference (CRISPRi).

Hawkins JS, Wong S, Peters JM, Almeida R, Qi LS.

Methods Mol Biol. 2015;1311:349-62. doi: 10.1007/978-1-4939-2687-9_23.

7.

Exploring the potential of genome editing CRISPR-Cas9 technology.

Singh V, Braddick D, Dhar PK.

Gene. 2017 Jan 30;599:1-18. doi: 10.1016/j.gene.2016.11.008. Epub 2016 Nov 9. Review.

PMID:
27836667
8.

Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance.

le Sage C, Lawo S, Panicker P, Scales TME, Rahman SA, Little AS, McCarthy NJ, Moore JD, Cross BCS.

Sci Rep. 2017 Dec 18;7(1):17693. doi: 10.1038/s41598-017-18172-6.

9.

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.

Konermann S, Brigham MD, Trevino AE, Joung J, Abudayyeh OO, Barcena C, Hsu PD, Habib N, Gootenberg JS, Nishimasu H, Nureki O, Zhang F.

Nature. 2015 Jan 29;517(7536):583-8. doi: 10.1038/nature14136. Epub 2014 Dec 10.

10.

Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design.

Smith JD, Suresh S, Schlecht U, Wu M, Wagih O, Peltz G, Davis RW, Steinmetz LM, Parts L, St Onge RP.

Genome Biol. 2016 Mar 8;17:45. doi: 10.1186/s13059-016-0900-9.

11.

Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM.

Jia Y, Xu RG, Ren X, Ewen-Campen B, Rajakumar R, Zirin J, Yang-Zhou D, Zhu R, Wang F, Mao D, Peng P, Qiao HH, Wang X, Liu LP, Xu B, Ji JY, Liu Q, Sun J, Perrimon N, Ni JQ.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4719-4724. doi: 10.1073/pnas.1800677115. Epub 2018 Apr 16.

PMID:
29666231
12.

Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression.

Luo ML, Mullis AS, Leenay RT, Beisel CL.

Nucleic Acids Res. 2015 Jan;43(1):674-81. doi: 10.1093/nar/gku971. Epub 2014 Oct 17.

13.

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression.

Radzisheuskaya A, Shlyueva D, Müller I, Helin K.

Nucleic Acids Res. 2016 Oct 14;44(18):e141. Epub 2016 Jun 28.

14.

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression.

Rosenbluh J, Xu H, Harrington W, Gill S, Wang X, Vazquez F, Root DE, Tsherniak A, Hahn WC.

Nat Commun. 2017 May 23;8:15403. doi: 10.1038/ncomms15403.

15.

Toward Whole-Transcriptome Editing with CRISPR-Cas9.

Heckl D, Charpentier E.

Mol Cell. 2015 May 21;58(4):560-2. doi: 10.1016/j.molcel.2015.05.016.

16.

CRISPR interference (CRISPRi) for sequence-specific control of gene expression.

Larson MH, Gilbert LA, Wang X, Lim WA, Weissman JS, Qi LS.

Nat Protoc. 2013 Nov;8(11):2180-96. doi: 10.1038/nprot.2013.132. Epub 2013 Oct 17.

17.

Potential pitfalls of CRISPR/Cas9-mediated genome editing.

Peng R, Lin G, Li J.

FEBS J. 2016 Apr;283(7):1218-31. doi: 10.1111/febs.13586. Epub 2015 Nov 27. Review.

18.

CRISPR/Cas9 library screening for drug target discovery.

Kurata M, Yamamoto K, Moriarity BS, Kitagawa M, Largaespada DA.

J Hum Genet. 2018 Feb;63(2):179-186. doi: 10.1038/s10038-017-0376-9. Epub 2017 Nov 20. Review.

PMID:
29158600
19.

Gene Repression in Haloarchaea Using the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas I-B System.

Stachler AE, Marchfelder A.

J Biol Chem. 2016 Jul 15;291(29):15226-42. doi: 10.1074/jbc.M116.724062. Epub 2016 May 16.

20.

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.

Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE.

Nat Biotechnol. 2016 Feb;34(2):184-191. doi: 10.1038/nbt.3437. Epub 2016 Jan 18.

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