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Items: 1 to 20 of 213

1.

RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication.

Wu MJ, Ke PY, Horng JT.

Biochem Biophys Res Commun. 2014 Nov 7;454(1):19-24. doi: 10.1016/j.bbrc.2014.10.008. Epub 2014 Oct 8.

PMID:
25305482
2.

Hepatitis C virus non-structural 5B protein interacts with cyclin A2 and regulates viral propagation.

Pham LV, Ngo HT, Lim YS, Hwang SB.

J Hepatol. 2012 Nov;57(5):960-6. doi: 10.1016/j.jhep.2012.07.006. Epub 2012 Jul 14.

PMID:
22796893
3.

Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors.

Jin G, Lee S, Choi M, Son S, Kim GW, Oh JW, Lee C, Lee K.

Eur J Med Chem. 2014 Mar 21;75:413-25. doi: 10.1016/j.ejmech.2014.01.062. Epub 2014 Jan 31.

PMID:
24561671
4.

NS5B induces up-regulation of the BH3-only protein, BIK, essential for the hepatitis C virus RNA replication and viral release.

Aweya JJ, Sze CW, Bayega A, Mohd-Ismail NK, Deng L, Hotta H, Tan YJ.

Virology. 2015 Jan 1;474:41-51. doi: 10.1016/j.virol.2014.10.027. Epub 2014 Nov 13.

5.

Antiviral therapy: inhibition of Hepatitis C Virus expression by RNA interference directed against the NS5B region of the viral genome.

Trejo-Avila L, Elizondo-González R, Trujillo-Murillo Kdel C, Zapata-Benavides P, Rodríguez-Padilla C, Rivas-Estilla AM.

Ann Hepatol. 2007 Jul-Sep;6(3):174-80.

6.

Interference of HCV replication by cell penetrable human monoclonal scFv specific to NS5B polymerase.

Thueng-in K, Thanongsaksrikul J, Jittavisutthikul S, Seesuay W, Chulanetra M, Sakolvaree Y, Srimanote P, Chaicumpa W.

MAbs. 2014;6(5):1327-39. doi: 10.4161/mabs.29978.

7.

Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

Ahmed-Belkacem A, Ahnou N, Barbotte L, Wychowski C, Pallier C, Brillet R, Pohl RT, Pawlotsky JM.

Gastroenterology. 2010 Mar;138(3):1112-22. doi: 10.1053/j.gastro.2009.11.053. Epub 2009 Dec 4.

8.

Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.

Howe AY, Cheng H, Johann S, Mullen S, Chunduru SK, Young DC, Bard J, Chopra R, Krishnamurthy G, Mansour T, O'Connell J.

Antimicrob Agents Chemother. 2008 Sep;52(9):3327-38. doi: 10.1128/AAC.00238-08. Epub 2008 Jun 16.

9.

Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.

Ludmerer SW, Graham DJ, Boots E, Murray EM, Simcoe A, Markel EJ, Grobler JA, Flores OA, Olsen DB, Hazuda DJ, LaFemina RL.

Antimicrob Agents Chemother. 2005 May;49(5):2059-69.

10.

Hepatitis C virus replication is modulated by the interaction of nonstructural protein NS5B and fatty acid synthase.

Huang JT, Tseng CP, Liao MH, Lu SC, Yeh WZ, Sakamoto N, Chen CM, Cheng JC.

J Virol. 2013 May;87(9):4994-5004. doi: 10.1128/JVI.02526-12. Epub 2013 Feb 20.

11.

Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus.

Fillebeen C, Rivas-Estilla AM, Bisaillon M, Ponka P, Muckenthaler M, Hentze MW, Koromilas AE, Pantopoulos K.

J Biol Chem. 2005 Mar 11;280(10):9049-57. Epub 2005 Jan 6.

12.

Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase.

Shih IH, Vliegen I, Peng B, Yang H, Hebner C, Paeshuyse J, Pürstinger G, Fenaux M, Tian Y, Mabery E, Qi X, Bahador G, Paulson M, Lehman LS, Bondy S, Tse W, Reiser H, Lee WA, Schmitz U, Neyts J, Zhong W.

Antimicrob Agents Chemother. 2011 Sep;55(9):4196-203. doi: 10.1128/AAC.00307-11. Epub 2011 Jul 11.

13.

Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells.

Beaulieu PL, Bousquet Y, Gauthier J, Gillard J, Marquis M, McKercher G, Pellerin C, Valois S, Kukolj G.

J Med Chem. 2004 Dec 30;47(27):6884-92.

PMID:
15615537
14.

Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase.

Kukolj G, McGibbon GA, McKercher G, Marquis M, Lefèbvre S, Thauvette L, Gauthier J, Goulet S, Poupart MA, Beaulieu PL.

J Biol Chem. 2005 Nov 25;280(47):39260-7. Epub 2005 Sep 27.

15.

Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Dhanak D, Duffy KJ, Johnston VK, Lin-Goerke J, Darcy M, Shaw AN, Gu B, Silverman C, Gates AT, Nonnemacher MR, Earnshaw DL, Casper DJ, Kaura A, Baker A, Greenwood C, Gutshall LL, Maley D, DelVecchio A, Macarron R, Hofmann GA, Alnoah Z, Cheng HY, Chan G, Khandekar S, Keenan RM, Sarisky RT.

J Biol Chem. 2002 Oct 11;277(41):38322-7. Epub 2002 Aug 6.

16.

A novel hepatitis C virus NS5B polymerase assay of de novo initiated RNA synthesis directed from a heteropolymeric RNA template.

Ferrari E, Huang HC.

Methods Mol Biol. 2013;1030:81-92. doi: 10.1007/978-1-62703-484-5_7.

PMID:
23821261
17.

Nonstructural 3 Protein of Hepatitis C Virus Modulates the Tribbles Homolog 3/Akt Signaling Pathway for Persistent Viral Infection.

Tran SC, Pham TM, Nguyen LN, Park EM, Lim YS, Hwang SB.

J Virol. 2016 Jul 27;90(16):7231-7247. doi: 10.1128/JVI.00326-16. Print 2016 Aug 15.

18.

Recent advances on the synthesis of hepatitis C virus NS5B RNA-dependent RNA-polymerase inhibitors.

Zhao C, Wang Y, Ma S.

Eur J Med Chem. 2015 Sep 18;102:188-214. doi: 10.1016/j.ejmech.2015.07.046. Epub 2015 Jul 31. Review.

PMID:
26276434
19.

Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon.

Shimakami T, Honda M, Kusakawa T, Murata T, Shimotohno K, Kaneko S, Murakami S.

J Virol. 2006 Apr;80(7):3332-40.

20.

Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells.

Lee JC, Tseng CK, Young KC, Sun HY, Wang SW, Chen WC, Lin CK, Wu YH.

Br J Pharmacol. 2014 Jan;171(1):237-52. doi: 10.1111/bph.12440.

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