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Items: 1 to 20 of 104

1.

A direct interaction between the sigma-1 receptor and the hERG voltage-gated K+ channel revealed by atomic force microscopy and homogeneous time-resolved fluorescence (HTRF®).

Balasuriya D, D'Sa L, Talker R, Dupuis E, Maurin F, Martin P, Borgese F, Soriani O, Edwardson JM.

J Biol Chem. 2014 Nov 14;289(46):32353-63. doi: 10.1074/jbc.M114.603506. Epub 2014 Sep 29.

2.

Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis.

Wu ZY, Yu DJ, Soong TW, Dawe GS, Bian JS.

J Biol Chem. 2011 Jun 24;286(25):22186-94. doi: 10.1074/jbc.M110.198853. Epub 2011 Apr 27.

3.

Protein kinase A activity at the endoplasmic reticulum surface is responsible for augmentation of human ether-a-go-go-related gene product (HERG).

Sroubek J, McDonald TV.

J Biol Chem. 2011 Jun 17;286(24):21927-36. doi: 10.1074/jbc.M110.201699. Epub 2011 May 2.

4.

Demonstration of a direct interaction between sigma-1 receptors and acid-sensing ion channels.

Carnally SM, Johannessen M, Henderson RM, Jackson MB, Edwardson JM.

Biophys J. 2010 Apr 7;98(7):1182-91. doi: 10.1016/j.bpj.2009.12.4293.

5.

Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene.

Roti EC, Myers CD, Ayers RA, Boatman DE, Delfosse SA, Chan EK, Ackerman MJ, January CT, Robertson GA.

J Biol Chem. 2002 Dec 6;277(49):47779-85. Epub 2002 Sep 20.

6.

The sigma-1 receptor binds to the Nav1.5 voltage-gated Na+ channel with 4-fold symmetry.

Balasuriya D, Stewart AP, Crottès D, Borgese F, Soriani O, Edwardson JM.

J Biol Chem. 2012 Oct 26;287(44):37021-9. doi: 10.1074/jbc.M112.382077. Epub 2012 Sep 5.

7.

Down-regulation of ether-a-go-go-related gene potassium channel protein through sustained stimulation of AT1 receptor by angiotensin II.

Cai Y, Wang Y, Xu J, Zuo X, Xu Y.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):852-7. doi: 10.1016/j.bbrc.2014.09.014. Epub 2014 Sep 10.

PMID:
25218469
8.
9.

Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells.

Crottès D, Martial S, Rapetti-Mauss R, Pisani DF, Loriol C, Pellissier B, Martin P, Chevet E, Borgese F, Soriani O.

J Biol Chem. 2011 Aug 12;286(32):27947-58. doi: 10.1074/jbc.M111.226738. Epub 2011 Jun 16.

10.

Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.

Massaeli H, Guo J, Xu J, Zhang S.

Circ Res. 2010 Apr 2;106(6):1072-82. doi: 10.1161/CIRCRESAHA.109.215970. Epub 2010 Feb 4.

PMID:
20133899
11.

A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-à-go-go-related gene channel.

Kinoshita K, Yamaguchi Y, Nishide K, Kimoto K, Nonobe Y, Fujita A, Asano K, Tabata T, Mori H, Inoue H, Hata Y, Fukurotani K, Nishida N.

J Cardiovasc Electrophysiol. 2012 Nov;23(11):1246-53. doi: 10.1111/j.1540-8167.2012.02383.x. Epub 2012 Jul 5.

PMID:
22764740
12.

KvLQT1 modulates the distribution and biophysical properties of HERG. A novel alpha-subunit interaction between delayed rectifier currents.

Ehrlich JR, Pourrier M, Weerapura M, Ethier N, Marmabachi AM, Hébert TE, Nattel S.

J Biol Chem. 2004 Jan 9;279(2):1233-41. Epub 2003 Oct 29.

13.

HERG-F463L potassium channels linked to long QT syndrome reduce I(Kr) current by a trafficking-deficient mechanism.

Yang HT, Sun CF, Cui CC, Xue XL, Zhang AF, Li HB, Wang DQ, Shu J.

Clin Exp Pharmacol Physiol. 2009 Aug;36(8):822-7. doi: 10.1111/j.1440-1681.2009.05150.x.

PMID:
19215240
14.

Retention in the endoplasmic reticulum as a mechanism of dominant-negative current suppression in human long QT syndrome.

Ficker E, Dennis AT, Obejero-Paz CA, Castaldo P, Taglialatela M, Brown AM.

J Mol Cell Cardiol. 2000 Dec;32(12):2327-37.

PMID:
11113008
15.

Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking.

Wang L, Wible BA, Wan X, Ficker E.

J Pharmacol Exp Ther. 2007 Feb;320(2):525-34. Epub 2006 Nov 9.

PMID:
17095614
16.

Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.

Wang L, Dennis AT, Trieu P, Charron F, Ethier N, Hebert TE, Wan X, Ficker E.

Mol Pharmacol. 2009 Apr;75(4):927-37. doi: 10.1124/mol.108.053793. Epub 2009 Jan 12.

17.

PKA phosphorylation of HERG protein regulates the rate of channel synthesis.

Chen J, Sroubek J, Krishnan Y, Li Y, Bian J, McDonald TV.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1244-54. doi: 10.1152/ajpheart.01252.2008. Epub 2009 Feb 20.

18.

Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum.

Wang Y, Huang X, Zhou J, Yang X, Li D, Mao H, Sun HH, Liu N, Lian J.

PLoS One. 2012;7(1):e29885. doi: 10.1371/journal.pone.0029885. Epub 2012 Jan 5.

19.

Interaction between the cardiac rapidly (IKr) and slowly (IKs) activating delayed rectifier potassium channels revealed by low K+-induced hERG endocytic degradation.

Guo J, Wang T, Yang T, Xu J, Li W, Fridman MD, Fisher JT, Zhang S.

J Biol Chem. 2011 Oct 7;286(40):34664-74. doi: 10.1074/jbc.M111.253351. Epub 2011 Aug 15.

20.

Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.

Gianulis EC, Liu Q, Trudeau MC.

J Gen Physiol. 2013 Oct;142(4):351-66. doi: 10.1085/jgp.201310995. Epub 2013 Sep 16.

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