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Items: 1 to 20 of 424

1.

Analgesia, enhancement of spinal morphine antinociception, and inhibition of tolerance by ultra-low dose of the α2A-adrenoceptor selective antagonist BRL44408.

Milne B, Jhamandas K, Sutak M, Grenier P, Cahill CM.

Eur J Pharmacol. 2014 Nov 15;743:89-97. doi: 10.1016/j.ejphar.2014.08.040. Epub 2014 Sep 19.

PMID:
25242119
2.

Stereo-selective inhibition of spinal morphine tolerance and hyperalgesia by an ultra-low dose of the alpha-2-adrenoceptor antagonist efaroxan.

Milne B, Jhamandas K, Sutak M, Grenier P, Cahill CM.

Eur J Pharmacol. 2013 Feb 28;702(1-3):227-34. doi: 10.1016/j.ejphar.2013.01.022. Epub 2013 Jan 29.

3.

Intrathecal atipamezole augments the antinociceptive effect of morphine in rats.

Lilius TO, Rauhala PV, Kambur O, Rossi SM, Väänänen AJ, Kalso EA.

Anesth Analg. 2012 Jun;114(6):1353-8. doi: 10.1213/ANE.0b013e31824c727d. Epub 2012 May 3.

PMID:
22556211
4.

Low doses of alpha 2-adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance.

Milne B, Sutak M, Cahill CM, Jhamandas K.

Br J Pharmacol. 2008 Dec;155(8):1264-78. doi: 10.1038/bjp.2008.353. Epub 2008 Sep 22.

5.
6.

Low dose alpha-2 antagonist paradoxically enhances rat norepinephrine and clonidine analgesia.

Milne B, Sutak M, Cahill CM, Jhamandas K.

Anesth Analg. 2011 Jun;112(6):1500-3. doi: 10.1213/ANE.0b013e3182121bae. Epub 2011 May 5.

PMID:
21543786
7.

Dissociation between morphine-induced spinal gliosis and analgesic tolerance by ultra-low-dose α2-adrenergic and cannabinoid CB1-receptor antagonists.

Grenier P, Wiercigroch D, Olmstead MC, Cahill CM.

Behav Pharmacol. 2018 Apr;29(2 and 3-Spec Issue):241-254. doi: 10.1097/FBP.0000000000000377.

PMID:
29481424
8.

Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine.

Nazarian A, Christianson CA, Hua XY, Yaksh TL.

Br J Pharmacol. 2008 Dec;155(7):1117-26. doi: 10.1038/bjp.2008.341. Epub 2008 Sep 1.

9.

Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I₂ receptor ligands.

Li JX, Zhang Y, Winter JC.

Eur J Pharmacol. 2011 Nov 1;669(1-3):59-65. doi: 10.1016/j.ejphar.2011.07.041. Epub 2011 Aug 16.

PMID:
21867697
10.

Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors.

Chabot-Doré AJ, Millecamps M, Naso L, Devost D, Trieu P, Piltonen M, Diatchenko L, Fairbanks CA, Wilcox GL, Hébert TE, Stone LS.

Neuropharmacology. 2015 Dec;99:285-300. doi: 10.1016/j.neuropharm.2015.08.010. Epub 2015 Aug 6.

12.

Antinociceptive and morphine modulatory actions of spinal orphanin FQ.

Jhamandas KH, Sutak M, Henderson G.

Can J Physiol Pharmacol. 1998 Mar;76(3):314-24.

PMID:
9673795
13.

Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of mu- and delta-opioid receptor antagonists.

Abul-Husn NS, Sutak M, Milne B, Jhamandas K.

Br J Pharmacol. 2007 Jul;151(6):877-87. Epub 2007 May 14.

14.

CB1 and CB2 cannabinoid receptor agonists induce peripheral antinociception by activation of the endogenous noradrenergic system.

Romero TR, Resende LC, Guzzo LS, Duarte ID.

Anesth Analg. 2013 Feb;116(2):463-72. doi: 10.1213/ANE.0b013e3182707859. Epub 2013 Jan 9.

PMID:
23302980
15.
16.

Inhibition of tolerance to spinal morphine antinociception by low doses of opioid receptor antagonists.

McNaull B, Trang T, Sutak M, Jhamandas K.

Eur J Pharmacol. 2007 Apr 10;560(2-3):132-41. Epub 2007 Jan 17.

PMID:
17307158
17.

Centhaquin antinociception in mice is mediated by α2A- and α2B- but not α2C-adrenoceptors.

Bhalla S, Ali I, Andurkar SV, Gulati A.

Eur J Pharmacol. 2013 Sep 5;715(1-3):328-36. doi: 10.1016/j.ejphar.2013.05.004. Epub 2013 May 24.

PMID:
23712005
18.

Tramadol antinociception is potentiated by clonidine through α₂-adrenergic and I₂-imidazoline but not by endothelin ET(A) receptors in mice.

Andurkar SV, Gendler L, Gulati A.

Eur J Pharmacol. 2012 May 15;683(1-3):109-15. doi: 10.1016/j.ejphar.2012.03.016. Epub 2012 Mar 16.

PMID:
22449379
19.

Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors.

Huang Q, Sun ML, Chen Y, Li XY, Wang YX.

J Ethnopharmacol. 2017 Jan 20;196:151-159. doi: 10.1016/j.jep.2016.12.027. Epub 2016 Dec 16.

PMID:
27989510
20.

Histamine in the locus coeruleus promotes descending noradrenergic inhibition of neuropathic hypersensitivity.

Wei H, Jin CY, Viisanen H, You HJ, Pertovaara A.

Pharmacol Res. 2014 Dec;90:58-66. doi: 10.1016/j.phrs.2014.09.007. Epub 2014 Oct 7.

PMID:
25304183

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