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Items: 1 to 20 of 166

1.

Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function.

Thompson AJ, Alqazzaz M, Price KL, Weston DA, Lummis SC.

Biochemistry. 2014 Oct 7;53(39):6183-8. doi: 10.1021/bi5008035. Epub 2014 Sep 19.

2.

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor.

Thompson AJ, Alqazzaz M, Ulens C, Lummis SC.

Neuropharmacology. 2012 Sep;63(4):761-7. doi: 10.1016/j.neuropharm.2012.05.027. Epub 2012 Jun 4.

3.

Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine.

Nys M, Wijckmans E, Farinha A, Yoluk Ö, Andersson M, Brams M, Spurny R, Peigneur S, Tytgat J, Lindahl E, Ulens C.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6696-E6703. Epub 2016 Oct 10.

4.

Cys-loop receptor channel blockers also block GLIC.

Alqazzaz M, Thompson AJ, Price KL, Breitinger HG, Lummis SC.

Biophys J. 2011 Dec 21;101(12):2912-8. doi: 10.1016/j.bpj.2011.10.055. Epub 2011 Dec 20.

5.

Probing Proline Residues in the Prokaryotic Ligand-Gated Ion Channel, ELIC.

Mosesso R, Dougherty DA, Lummis SCR.

Biochemistry. 2018 Jul 10;57(27):4036-4043. doi: 10.1021/acs.biochem.8b00379. Epub 2018 Jun 21.

PMID:
29927250
6.
7.

Probing residues in the pore-forming (M2) domain of the Cys-loop receptor homologue GLIC reveals some unusual features.

Alqazzaz MA, Lummis SC.

Mol Membr Biol. 2015;32(1):26-31. doi: 10.3109/09687688.2015.1023377. Epub 2015 Apr 13.

PMID:
25865129
8.

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine.

Pan J, Chen Q, Willenbring D, Yoshida K, Tillman T, Kashlan OB, Cohen A, Kong XP, Xu Y, Tang P.

Nat Commun. 2012 Mar 6;3:714. doi: 10.1038/ncomms1703.

9.

Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).

Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SC, Ulens C.

J Biol Chem. 2013 Mar 22;288(12):8355-64. doi: 10.1074/jbc.M112.424507. Epub 2013 Jan 30.

10.

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals.

Gonzalez-Gutierrez G, Lukk T, Agarwal V, Papke D, Nair SK, Grosman C.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6331-6. doi: 10.1073/pnas.1119268109. Epub 2012 Apr 2.

11.

An internally modulated, thermostable, pH-sensitive Cys loop receptor from the hydrothermal vent worm Alvinella pompejana.

Juneja P, Horlacher R, Bertrand D, Krause R, Marger F, Welte W.

J Biol Chem. 2014 May 23;289(21):15130-40. doi: 10.1074/jbc.M113.525576. Epub 2014 Apr 9.

12.

Structural insights into Cys-loop receptor function and ligand recognition.

Nys M, Kesters D, Ulens C.

Biochem Pharmacol. 2013 Oct 15;86(8):1042-53. doi: 10.1016/j.bcp.2013.07.001. Epub 2013 Jul 10. Review.

PMID:
23850718
13.

Functional evaluation of key interactions evident in the structure of the eukaryotic Cys-loop receptor GluCl.

Daeffler KN, Lester HA, Dougherty DA.

ACS Chem Biol. 2014 Oct 17;9(10):2283-90. doi: 10.1021/cb500323d. Epub 2014 Aug 5.

14.

Importance of lipid-pore loop interface for potassium channel structure and function.

van der Cruijsen EA, Nand D, Weingarth M, Prokofyev A, Hornig S, Cukkemane AA, Bonvin AM, Becker S, Hulse RE, Perozo E, Pongs O, Baldus M.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13008-13. doi: 10.1073/pnas.1305563110. Epub 2013 Jul 23.

15.

The prokaryote ligand-gated ion channel ELIC captured in a pore blocker-bound conformation by the Alzheimer's disease drug memantine.

Ulens C, Spurny R, Thompson AJ, Alqazzaz M, Debaveye S, Han L, Price K, Villalgordo JM, Tresadern G, Lynch JW, Lummis SC.

Structure. 2014 Oct 7;22(10):1399-407. doi: 10.1016/j.str.2014.07.013. Epub 2014 Sep 4.

16.

The desensitization gate of inhibitory Cys-loop receptors.

Gielen M, Thomas P, Smart TG.

Nat Commun. 2015 Apr 20;6:6829. doi: 10.1038/ncomms7829.

17.

Contribution of valine 7' of TMD2 to gating of neuronal alpha3 receptor subtypes.

Nieves-Cintrón M, Caballero-Rivera D, Navedo MF, Lasalde-Dominicci JA.

J Neurosci Res. 2006 Dec;84(8):1778-88.

PMID:
17044037
18.

Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor.

Thompson AJ, Duke RK, Lummis SC.

Mol Pharmacol. 2011 Jul;80(1):183-90. doi: 10.1124/mol.111.071415. Epub 2011 Apr 19.

19.

Functional characterization and visualization of a GABAA receptor-GFP chimera expressed in Xenopus oocytes.

Bueno OF, Robinson LC, Alvarez-Hernandez X, Leidenheimer NJ.

Brain Res Mol Brain Res. 1998 Aug 31;59(2):165-77.

PMID:
9729362
20.

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