Similar articles for PMID: 25228699

Year	Number of Results
1999	1
2005	2
2006	3
2007	5
2008	3
2009	15
2010	14
2011	10
2012	19
2013	20
2014	22
2015	15
2016	5
2017	1
2018	3
2019	3
2020	8
2021	17
2022	13
2023	5
2024	0

1

Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.

Liu Z, Galemmo RA Jr, Fraser KB, Moehle MS, Sen S, Volpicelli-Daley LA, DeLucas LJ, Ross LJ, Valiyaveettil J, Moukha-Chafiq O, Pathak AK, Ananthan S, Kezar H, White EL, Gupta V, Maddry JA, Suto MJ, West AB. Liu Z, et al. J Biol Chem. 2014 Nov 21;289(47):32937-51. doi: 10.1074/jbc.M114.602318. Epub 2014 Sep 16. J Biol Chem. 2014. PMID: 25228699 Free PMC article.

2

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.

Galatsis P, Henderson JL, Kormos BL, Han S, Kurumbail RG, Wager TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD. Galatsis P, et al. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4132-40. doi: 10.1016/j.bmcl.2014.07.052. Epub 2014 Jul 30. Bioorg Med Chem Lett. 2014. PMID: 25113930

3

The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro.

Liu Z, West AB. Liu Z, et al. Biochim Biophys Acta Proteins Proteom. 2017 Mar;1865(3):274-280. doi: 10.1016/j.bbapap.2016.12.001. Epub 2016 Dec 8. Biochim Biophys Acta Proteins Proteom. 2017. PMID: 27939437 Free PMC article.

4

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.

Webber PJ, Smith AD, Sen S, Renfrow MB, Mobley JA, West AB. Webber PJ, et al. J Mol Biol. 2011 Sep 9;412(1):94-110. doi: 10.1016/j.jmb.2011.07.033. Epub 2011 Jul 22. J Mol Biol. 2011. PMID: 21806997 Free PMC article.

5

The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition.

Covy JP, Giasson BI. Covy JP, et al. J Neurochem. 2010 Oct;115(1):36-46. doi: 10.1111/j.1471-4159.2010.06894.x. Epub 2010 Aug 19. J Neurochem. 2010. PMID: 20626563 Free PMC article.

6

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.

Law BM, Spain VA, Leinster VH, Chia R, Beilina A, Cho HJ, Taymans JM, Urban MK, Sancho RM, Blanca Ramírez M, Biskup S, Baekelandt V, Cai H, Cookson MR, Berwick DC, Harvey K. Law BM, et al. J Biol Chem. 2014 Jan 10;289(2):895-908. doi: 10.1074/jbc.M113.507913. Epub 2013 Nov 25. J Biol Chem. 2014. PMID: 24275654 Free PMC article.

7

ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?

Gillardon F, Kremmer E, Froehlich T, Ueffing M, Hengerer B, Gloeckner CJ. Gillardon F, et al. J Neurosci Methods. 2013 Mar 30;214(1):62-8. doi: 10.1016/j.jneumeth.2012.12.015. Epub 2013 Jan 12. J Neurosci Methods. 2013. PMID: 23318290

8

Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors.

Liu M, Poulose S, Schuman E, Zaitsev AD, Dobson B, Auerbach K, Seyb K, Cuny GD, Glicksman MA, Stein RL, Yue Z. Liu M, et al. Anal Biochem. 2010 Sep 15;404(2):186-92. doi: 10.1016/j.ab.2010.05.033. Epub 2010 Jun 2. Anal Biochem. 2010. PMID: 20566370 Free PMC article.

9

Development of a high-throughput AlphaScreen assay measuring full-length LRRK2(G2019S) kinase activity using moesin protein substrate.

Pedro L, Padrós J, Beaudet L, Schubert HD, Gillardon F, Dahan S. Pedro L, et al. Anal Biochem. 2010 Sep 1;404(1):45-51. doi: 10.1016/j.ab.2010.04.028. Epub 2010 Apr 29. Anal Biochem. 2010. PMID: 20434426

10

Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2.

Li X, Moore DJ, Xiong Y, Dawson TM, Dawson VL. Li X, et al. J Biol Chem. 2010 Sep 17;285(38):29569-76. doi: 10.1074/jbc.M110.127639. Epub 2010 Jul 1. J Biol Chem. 2010. PMID: 20595391 Free PMC article.

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