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Items: 1 to 20 of 163

1.

The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation.

Csibi A, Lee G, Yoon SO, Tong H, Ilter D, Elia I, Fendt SM, Roberts TM, Blenis J.

Curr Biol. 2014 Oct 6;24(19):2274-80. doi: 10.1016/j.cub.2014.08.007. Epub 2014 Sep 11.

2.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.

3.

Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.

Hong S, Zhao B, Lombard DB, Fingar DC, Inoki K.

J Biol Chem. 2014 May 9;289(19):13132-41. doi: 10.1074/jbc.M113.520734. Epub 2014 Mar 20.

4.

Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.

Dennis MD, Jefferson LS, Kimball SR.

J Biol Chem. 2012 Dec 14;287(51):42890-9. doi: 10.1074/jbc.M112.404822. Epub 2012 Oct 26.

5.

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N.

Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001.

6.

p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.

Cam M, Bid HK, Xiao L, Zambetti GP, Houghton PJ, Cam H.

J Biol Chem. 2014 Feb 14;289(7):4083-94. doi: 10.1074/jbc.M113.530303. Epub 2013 Dec 23.

7.

Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism.

Schriever SC, Deutsch MJ, Adamski J, Roscher AA, Ensenauer R.

J Nutr Biochem. 2013 May;24(5):824-31. doi: 10.1016/j.jnutbio.2012.04.018. Epub 2012 Aug 13.

PMID:
22898570
8.

A conserved role of IQGAP1 in regulating TOR complex 1.

Tekletsadik YK, Sonn R, Osman MA.

J Cell Sci. 2012 Apr 15;125(Pt 8):2041-52. doi: 10.1242/jcs.098947. Epub 2012 Feb 10.

9.

Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.

Li J, Csibi A, Yang S, Hoffman GR, Li C, Zhang E, Yu JJ, Blenis J.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E21-9. doi: 10.1073/pnas.1417015112. Epub 2014 Dec 18.

10.

mTORC1 regulates glutamine metabolism.

[No authors listed]

Cancer Discov. 2013 Jul;3(7):OF25. doi: 10.1158/2159-8290.CD-RW2013-106. Epub 2013 May 16.

11.

A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.

Liu P, Ge M, Hu J, Li X, Che L, Sun K, Cheng L, Huang Y, Pilo MG, Cigliano A, Pes GM, Pascale RM, Brozzetti S, Vidili G, Porcu A, Cossu A, Palmieri G, Sini MC, Ribback S, Dombrowski F, Tao J, Calvisi DF, Chen L, Chen X.

Hepatology. 2017 Jul;66(1):167-181. doi: 10.1002/hep.29183. Epub 2017 May 22.

12.
13.

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.

Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW, Phang JM.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8983-8. doi: 10.1073/pnas.1203244109. Epub 2012 May 21.

14.

Fisetin regulates obesity by targeting mTORC1 signaling.

Jung CH, Kim H, Ahn J, Jeon TI, Lee DH, Ha TY.

J Nutr Biochem. 2013 Aug;24(8):1547-54. doi: 10.1016/j.jnutbio.2013.01.003. Epub 2013 Mar 18.

PMID:
23517912
15.

Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle.

Apró W, Wang L, Pontén M, Blomstrand E, Sahlin K.

Am J Physiol Endocrinol Metab. 2013 Jul 1;305(1):E22-32. doi: 10.1152/ajpendo.00091.2013. Epub 2013 Apr 30.

16.

Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling.

Gao S, Duan C, Gao G, Wang X, Yang H.

Int J Biochem Cell Biol. 2015 Jul;64:25-33. doi: 10.1016/j.biocel.2015.03.006. Epub 2015 Mar 23.

PMID:
25813876
17.

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition.

Lampa M, Arlt H, He T, Ospina B, Reeves J, Zhang B, Murtie J, Deng G, Barberis C, Hoffmann D, Cheng H, Pollard J, Winter C, Richon V, Garcia-Escheverria C, Adrian F, Wiederschain D, Srinivasan L.

PLoS One. 2017 Sep 26;12(9):e0185092. doi: 10.1371/journal.pone.0185092. eCollection 2017.

18.

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J.

Cell. 2013 May 9;153(4):840-54. doi: 10.1016/j.cell.2013.04.023.

19.

PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester.

Ni Y, Wang L, Zhang J, Pang Z, Liu Q, Du J.

Int J Biochem Cell Biol. 2015 Mar;60:34-42. doi: 10.1016/j.biocel.2014.12.018. Epub 2015 Jan 9.

PMID:
25578563
20.

Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation.

Huck B, Duss S, Hausser A, Olayioye MA.

J Biol Chem. 2014 Feb 7;289(6):3138-47. doi: 10.1074/jbc.M113.502633. Epub 2013 Dec 11.

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