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Items: 1 to 20 of 94

1.

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation.

Romberg N, Al Moussawi K, Nelson-Williams C, Stiegler AL, Loring E, Choi M, Overton J, Meffre E, Khokha MK, Huttner AJ, West B, Podoltsev NA, Boggon TJ, Kazmierczak BI, Lifton RP.

Nat Genet. 2014 Oct;46(10):1135-1139. doi: 10.1038/ng.3066. Epub 2014 Sep 14.

2.

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.

Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O'Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R.

Nat Genet. 2014 Oct;46(10):1140-6. doi: 10.1038/ng.3089. Epub 2014 Sep 14.

3.

Autoinflammation: NLRC4 mutation causes rare autoinflammatory disease.

Bernard NJ.

Nat Rev Rheumatol. 2014 Nov;10(11):635. doi: 10.1038/nrrheum.2014.170. Epub 2014 Sep 30. No abstract available.

PMID:
25266450
4.

NLRC4 gets out of control.

Khameneh HJ, Mortellaro A.

Nat Genet. 2014 Oct;46(10):1048-9. doi: 10.1038/ng.3100.

PMID:
25257084
5.

A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death.

Raghawan AK, Sripada A, Gopinath G, Pushpanjali P, Kumar Y, Radha V, Swarup G.

J Biol Chem. 2017 Jan 27;292(4):1218-1230. doi: 10.1074/jbc.M116.763979. Epub 2016 Dec 14.

6.

Novel NLRC4 Mutation Causes a Syndrome of Perinatal Autoinflammation With Hemophagocytic Lymphohistiocytosis, Hepatosplenomegaly, Fetal Thrombotic Vasculopathy, and Congenital Anemia and Ascites.

Liang J, Alfano DN, Squires JE, Riley MM, Parks WT, Kofler J, El-Gharbawy A, Madan-Kheterpal S, Acquaro R, Picarsic J.

Pediatr Dev Pathol. 2017 Nov-Dec;20(6):498-505. doi: 10.1177/1093526616686890. Epub 2017 Mar 15.

PMID:
28403691
7.

An inherited mutation in NLRC4 causes autoinflammation in human and mice.

Kitamura A, Sasaki Y, Abe T, Kano H, Yasutomo K.

J Exp Med. 2014 Nov 17;211(12):2385-96. doi: 10.1084/jem.20141091. Epub 2014 Nov 10.

8.

NLRC4 inflammasomopathies.

Romberg N, Vogel TP, Canna SW.

Curr Opin Allergy Clin Immunol. 2017 Dec;17(6):398-404. doi: 10.1097/ACI.0000000000000396. Review.

9.

Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition.

Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM.

J Allergy Clin Immunol. 2017 May;139(5):1698-1701. doi: 10.1016/j.jaci.2016.10.022. Epub 2016 Nov 19. No abstract available.

10.

Phosphorylation of NLRC4 is critical for inflammasome activation.

Qu Y, Misaghi S, Izrael-Tomasevic A, Newton K, Gilmour LL, Lamkanfi M, Louie S, Kayagaki N, Liu J, Kömüves L, Cupp JE, Arnott D, Monack D, Dixit VM.

Nature. 2012 Oct 25;490(7421):539-42. doi: 10.1038/nature11429. Epub 2012 Aug 12.

PMID:
22885697
11.

Erythematous nodes, urticarial rash and arthralgias in a large pedigree with NLRC4-related autoinflammatory disease, expansion of the phenotype.

Volker-Touw CM, de Koning HD, Giltay JC, de Kovel CG, van Kempen TS, Oberndorff KM, Boes ML, van Steensel MA, van Well GT, Blokx WA, Schalkwijk J, Simon A, Frenkel J, van Gijn ME.

Br J Dermatol. 2017 Jan;176(1):244-248. doi: 10.1111/bjd.14757. Epub 2016 Dec 8. No abstract available.

PMID:
27203668
12.

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface.

Moghaddas F, Zeng P, Zhang Y, Schützle H, Brenner S, Hofmann SR, Berner R, Zhao Y, Lu B, Chen X, Zhang L, Cheng S, Winkler S, Lehmberg K, Canna SW, Czabotar PE, Wicks IP, De Nardo D, Hedrich CM, Zeng H, Masters SL.

J Allergy Clin Immunol. 2018 Dec;142(6):1956-1967.e6. doi: 10.1016/j.jaci.2018.04.033. Epub 2018 May 17.

13.

A clinical update on inflammasomopathies.

Sönmez HE, Özen S.

Int Immunol. 2017 Nov 1;29(9):393-400. doi: 10.1093/intimm/dxx020. Review.

PMID:
28387826
14.

Nlrc4/Ipaf/CLAN/CARD12: more than a flagellin sensor.

Abdelaziz DH, Amr K, Amer AO.

Int J Biochem Cell Biol. 2010 Jun;42(6):789-91. doi: 10.1016/j.biocel.2010.01.003. Epub 2010 Jan 11. Review.

15.

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

Zhao Y, Yang J, Shi J, Gong YN, Lu Q, Xu H, Liu L, Shao F.

Nature. 2011 Sep 14;477(7366):596-600. doi: 10.1038/nature10510.

PMID:
21918512
16.

Too much of a good thing: NLRC4 and autoinflammation.

Anderson MS.

J Exp Med. 2014 Nov 17;211(12):2329. doi: 10.1084/jem.21112insight5. No abstract available.

17.

Identification of a High-Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection.

Kawasaki Y, Oda H, Ito J, Niwa A, Tanaka T, Hijikata A, Seki R, Nagahashi A, Osawa M, Asaka I, Watanabe A, Nishimata S, Shirai T, Kawashima H, Ohara O, Nakahata T, Nishikomori R, Heike T, Saito MK.

Arthritis Rheumatol. 2017 Feb;69(2):447-459. doi: 10.1002/art.39960.

18.

The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus.

Zhao Y, Shao F.

Immunol Rev. 2015 May;265(1):85-102. doi: 10.1111/imr.12293. Review.

PMID:
25879286
19.

[NLRC4 associated autoinflammatory diseases: A systematic review of the current literature].

Rodrigues F, Hentgen V, Bachmeyer C, Kone-Paut I, Belot A, Grateau G, Sarrabay G, Georgin-Lavialle S.

Rev Med Interne. 2018 Apr;39(4):279-286. doi: 10.1016/j.revmed.2018.02.003. Epub 2018 Feb 26. Review. French.

PMID:
29496273
20.

The NAIP/NLRC4 inflammasomes.

Vance RE.

Curr Opin Immunol. 2015 Feb;32:84-9. doi: 10.1016/j.coi.2015.01.010. Epub 2015 Jan 24. Review.

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