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Long-acting glucose-dependent insulinotropic polypeptide ameliorates obesity-induced adipose tissue inflammation.

Varol C, Zvibel I, Spektor L, Mantelmacher FD, Vugman M, Thurm T, Khatib M, Elmaliah E, Halpern Z, Fishman S. Varol C, et al. J Immunol. 2014 Oct 15;193(8):4002-9. doi: 10.4049/jimmunol.1401149. Epub 2014 Sep 12. J Immunol. 2014. PMID: 25217161

GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial.

Gögebakan Ö, Osterhoff MA, Schüler R, Pivovarova O, Kruse M, Seltmann AC, Mosig AS, Rudovich N, Nauck M, Pfeiffer AF. Gögebakan Ö, et al. Diabetologia. 2015 Aug;58(8):1759-68. doi: 10.1007/s00125-015-3618-4. Epub 2015 May 21. Diabetologia. 2015. PMID: 25994074 Clinical Trial.

Increased GIP signaling induces adipose inflammation via a HIF-1α-dependent pathway and impairs insulin sensitivity in mice.

Chen S, Okahara F, Osaki N, Shimotoyodome A. Chen S, et al. Am J Physiol Endocrinol Metab. 2015 Mar 1;308(5):E414-25. doi: 10.1152/ajpendo.00418.2014. Epub 2014 Dec 23. Am J Physiol Endocrinol Metab. 2015. PMID: 25537494 Free article.

GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.

McClean PL, Irwin N, Cassidy RS, Holst JJ, Gault VA, Flatt PR. McClean PL, et al. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1746-55. doi: 10.1152/ajpendo.00460.2007. Epub 2007 Sep 11. Am J Physiol Endocrinol Metab. 2007. PMID: 17848629 Free article.

The influence of Glucose-dependent Insulinotropic Polypeptide (GIP) on human adipose tissue and fat metabolism: Implications for obesity, type 2 diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD).

Thondam SK, Cuthbertson DJ, Wilding JPH. Thondam SK, et al. Peptides. 2020 Mar;125:170208. doi: 10.1016/j.peptides.2019.170208. Epub 2019 Nov 20. Peptides. 2020. PMID: 31759125 Review.

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance.

Lee BC, Lee J. Lee BC, et al. Biochim Biophys Acta. 2014 Mar;1842(3):446-62. doi: 10.1016/j.bbadis.2013.05.017. Epub 2013 May 22. Biochim Biophys Acta. 2014. PMID: 23707515 Free PMC article. Review.

Adiponectin Limits IFN-γ and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis.

Surendar J, Frohberger SJ, Karunakaran I, Schmitt V, Stamminger W, Neumann AL, Wilhelm C, Hoerauf A, Hübner MP. Surendar J, et al. Front Immunol. 2019 Oct 29;10:2555. doi: 10.3389/fimmu.2019.02555. eCollection 2019. Front Immunol. 2019. PMID: 31736971 Free PMC article.

Disruption of GIP/GIPR axis in human adipose tissue is linked to obesity and insulin resistance.

Ceperuelo-Mallafré V, Duran X, Pachón G, Roche K, Garrido-Sánchez L, Vilarrasa N, Tinahones FJ, Vicente V, Pujol J, Vendrell J, Fernández-Veledo S. Ceperuelo-Mallafré V, et al. J Clin Endocrinol Metab. 2014 May;99(5):E908-19. doi: 10.1210/jc.2013-3350. Epub 2014 Feb 10. J Clin Endocrinol Metab. 2014. PMID: 24512489 Free article.

Sub-chronic administration of stable GIP analog in mice decreases serum LPL activity and body weight.

Szalowska E, Meijer K, Kloosterhuis N, Razaee F, Priebe M, Vonk RJ. Szalowska E, et al. Peptides. 2011 May;32(5):938-45. doi: 10.1016/j.peptides.2011.02.011. Epub 2011 Feb 18. Peptides. 2011. PMID: 21334410

Dietary flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration in obese, insulin-resistant rats.

Baranowski M, Enns J, Blewett H, Yakandawala U, Zahradka P, Taylor CG. Baranowski M, et al. Cytokine. 2012 Aug;59(2):382-91. doi: 10.1016/j.cyto.2012.04.004. Epub 2012 May 14. Cytokine. 2012. PMID: 22592037

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