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Items: 1 to 20 of 121

1.

C5a and bradykinin receptor cross-talk regulates innate and adaptive immunity in Trypanosoma cruzi infection.

Schmitz V, Almeida LN, Svensjö E, Monteiro AC, Köhl J, Scharfstein J.

J Immunol. 2014 Oct 1;193(7):3613-23. doi: 10.4049/jimmunol.1302417. Epub 2014 Sep 3.

2.

Bradykinin B2 Receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses.

Monteiro AC, Schmitz V, Morrot A, de Arruda LB, Nagajyothi F, Granato A, Pesquero JB, Müller-Esterl W, Tanowitz HB, Scharfstein J.

PLoS Pathog. 2007 Nov;3(11):e185.

3.

Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi.

Monteiro AC, Schmitz V, Svensjo E, Gazzinelli RT, Almeida IC, Todorov A, de Arruda LB, Torrecilhas AC, Pesquero JB, Morrot A, Bouskela E, Bonomo A, Lima AP, Müller-Esterl W, Scharfstein J.

J Immunol. 2006 Nov 1;177(9):6325-35.

4.

Mast Cell Coupling to the Kallikrein-Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease.

Nascimento CR, Andrade D, Carvalho-Pinto CE, Serra RR, Vellasco L, Brasil G, Ramos-Junior ES, da Mota JB, Almeida LN, Andrade MV, Correia Soeiro MN, Juliano L, Alvarenga PH, Oliveira AC, Sicuro FL, de Carvalho ACC, Svensjö E, Scharfstein J.

Front Immunol. 2017 Aug 2;8:840. doi: 10.3389/fimmu.2017.00840. eCollection 2017.

5.

Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors.

Schmitz V, Svensjö E, Serra RR, Teixeira MM, Scharfstein J.

J Leukoc Biol. 2009 Jun;85(6):1005-14. doi: 10.1189/jlb.1108693. Epub 2009 Mar 17.

PMID:
19293401
6.

Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy.

Andrade D, Serra R, Svensjö E, Lima AP, Ramos ES Jr, Fortes FS, Morandini AC, Morandi V, Soeiro Mde N, Tanowitz HB, Scharfstein J.

Br J Pharmacol. 2012 Mar;165(5):1333-47. doi: 10.1111/j.1476-5381.2011.01609.x.

7.

Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway.

Scharfstein J, Monteiro AC, Schmitz V, Svensjö E.

Biol Chem. 2008 Aug;389(8):1015-24. doi: 10.1515/BC.2008.126. Review.

PMID:
18979626
8.

Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice.

Schnapp AR, Eickhoff CS, Sizemore D, Curtiss R 3rd, Hoft DF.

Infect Immun. 2002 Sep;70(9):5065-74.

9.

Trypanosoma cruzi induces edematogenic responses in mice and invades cardiomyocytes and endothelial cells in vitro by activating distinct kinin receptor (B1/B2) subtypes.

Todorov AG, Andrade D, Pesquero JB, Araujo Rde C, Bader M, Stewart J, Gera L, Müller-Esterl W, Morandi V, Goldenberg RC, Neto HC, Scharfstein J.

FASEB J. 2003 Jan;17(1):73-5. Epub 2002 Nov 1.

PMID:
12424228
10.

Induction of B- and T-cell responses to cruzipain in the murine model of Trypanosoma cruzi infection.

Schnapp AR, Eickhoff CS, Scharfstein J, Hoft DF.

Microbes Infect. 2002 Jul;4(8):805-13.

PMID:
12270727
11.

Specific humoral immunity versus polyclonal B cell activation in Trypanosoma cruzi infection of susceptible and resistant mice.

Bryan MA, Guyach SE, Norris KA.

PLoS Negl Trop Dis. 2010 Jul 6;4(7):e733. doi: 10.1371/journal.pntd.0000733.

12.

Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite.

Giordanengo L, Guiñazú N, Stempin C, Fretes R, Cerbán F, Gea S.

Eur J Immunol. 2002 Apr;32(4):1003-11.

13.

Subverting bradykinin-evoked inflammation by co-opting the contact system: lessons from survival strategies of Trypanosoma cruzi.

Scharfstein J.

Curr Opin Hematol. 2018 Sep;25(5):347-357. doi: 10.1097/MOH.0000000000000444.

PMID:
30028741
14.

Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex.

Svensjö E, Batista PR, Brodskyn CI, Silva R, Lima AP, Schmitz V, Saraiva E, Pesquero JB, Mori MA, Müller-Esterl W, Scharfstein J.

Microbes Infect. 2006 Jan;8(1):206-20. Epub 2005 Sep 8.

PMID:
16203170
15.

Targeting C3a/C5a receptors inhibits human mesangial cell proliferation and alleviates immunoglobulin A nephropathy in mice.

Zhang Y, Yan X, Zhao T, Xu Q, Peng Q, Hu R, Quan S, Zhou Y, Xing G.

Clin Exp Immunol. 2017 Jul;189(1):60-70. doi: 10.1111/cei.12961. Epub 2017 Apr 10.

16.

Dendritic cell function in allostimulation is modulated by C5aR signaling.

Peng Q, Li K, Wang N, Li Q, Asgari E, Lu B, Woodruff TM, Sacks SH, Zhou W.

J Immunol. 2009 Nov 15;183(10):6058-68. doi: 10.4049/jimmunol.0804186. Epub 2009 Oct 28.

17.

Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice.

Moulton RA, Mashruwala MA, Smith AK, Lindsey DR, Wetsel RA, Haviland DL, Hunter RL, Jagannath C.

J Leukoc Biol. 2007 Oct;82(4):956-67. Epub 2007 Aug 3.

PMID:
17675563
18.

Mesenchymal stem cells alleviate acute kidney injury by down-regulating C5a/C5aR pathway activation.

Tang M, Zhang K, Li Y, He QH, Li GQ, Zheng QY, Zhang KQ.

Int Urol Nephrol. 2018 Aug;50(8):1545-1553. doi: 10.1007/s11255-018-1844-7. Epub 2018 Mar 28.

PMID:
29594894
19.

Immune cell-derived C3a and C5a costimulate human T cell alloimmunity.

Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS.

Am J Transplant. 2013 Oct;13(10):2530-9. doi: 10.1111/ajt.12405. Epub 2013 Sep 6.

20.

Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus.

Pawaria S, Ramani K, Maers K, Liu Y, Kane LP, Levesque MC, Biswas PS.

J Immunol. 2014 Oct 1;193(7):3288-95. doi: 10.4049/jimmunol.1401322. Epub 2014 Aug 22.

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