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Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.

Alejandro EU, Gregg B, Wallen T, Kumusoglu D, Meister D, Chen A, Merrins MJ, Satin LS, Liu M, Arvan P, Bernal-Mizrachi E.

J Clin Invest. 2014 Oct;124(10):4395-410. doi: 10.1172/JCI74237. Epub 2014 Sep 2.


Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass.

Alejandro EU, Bozadjieva N, Blandino-Rosano M, Wasan MA, Elghazi L, Vadrevu S, Satin L, Bernal-Mizrachi E.

Diabetes. 2017 Aug;66(8):2150-2162. doi: 10.2337/db16-1349. Epub 2017 May 25.


Maternal Low Protein Isocaloric Diet Suppresses Pancreatic β-Cell Proliferation in Mouse Offspring via miR-15b.

Su Y, Jiang X, Li Y, Li F, Cheng Y, Peng Y, Song D, Hong J, Ning G, Cao Y, Wang W.

Endocrinology. 2016 Dec;157(12):4782-4793. Epub 2016 Oct 18.


Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass.

King R, Hill JL, Saha B, Tong Y, Strutt BJ, Russell MA, Morgan NG, Richardson SJ, Hill DJ.

Nutrients. 2019 Mar 12;11(3). pii: E605. doi: 10.3390/nu11030605.


Maternal taurine supplementation in rats partially prevents the adverse effects of early-life protein deprivation on β-cell function and insulin sensitivity.

Tang C, Marchand K, Lam L, Lux-Lantos V, Thyssen SM, Guo J, Giacca A, Arany E.

Reproduction. 2013 May 21;145(6):609-20. doi: 10.1530/REP-12-0388. Print 2013 Jun.


Maternal high-fat diet induces insulin resistance and deterioration of pancreatic β-cell function in adult offspring with sex differences in mice.

Yokomizo H, Inoguchi T, Sonoda N, Sakaki Y, Maeda Y, Inoue T, Hirata E, Takei R, Ikeda N, Fujii M, Fukuda K, Sasaki H, Takayanagi R.

Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1163-75. doi: 10.1152/ajpendo.00688.2013. Epub 2014 Apr 1.


The programming of cardiac hypertrophy in the offspring by maternal obesity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation.

Fernandez-Twinn DS, Blackmore HL, Siggens L, Giussani DA, Cross CM, Foo R, Ozanne SE.

Endocrinology. 2012 Dec;153(12):5961-71. doi: 10.1210/en.2012-1508. Epub 2012 Oct 15.


Decreased basal insulin secretion from pancreatic islets of pups in a rat model of maternal obesity.

Zambrano E, Sosa-Larios T, Calzada L, Ibáñez CA, Mendoza-Rodríguez CA, Morales A, Morimoto S.

J Endocrinol. 2016 Oct;231(1):49-57. doi: 10.1530/JOE-16-0321. Epub 2016 Aug 5.


Interaction between maternal and postnatal high fat diet leads to a greater risk of myocardial dysfunction in offspring via enhanced lipotoxicity, IRS-1 serine phosphorylation and mitochondrial defects.

Turdi S, Ge W, Hu N, Bradley KM, Wang X, Ren J.

J Mol Cell Cardiol. 2013 Feb;55:117-29. doi: 10.1016/j.yjmcc.2012.12.007. Epub 2012 Dec 22.


Maternal Low-Protein Diet Modulates Glucose Metabolism and Hepatic MicroRNAs Expression in the Early Life of Offspring †.

Zheng J, Xiao X, Zhang Q, Wang T, Yu M, Xu J.

Nutrients. 2017 Feb 27;9(3). pii: E205. doi: 10.3390/nu9030205.


Impaired hypothalamic mTOR activation in the adult rat offspring born to mothers fed a low-protein diet.

Guzmán-Quevedo O, Da Silva Aragão R, Pérez García G, Matos RJ, de Sa Braga Oliveira A, Manhães de Castro R, Bolaños-Jiménez F.

PLoS One. 2013 Sep 9;8(9):e74990. doi: 10.1371/journal.pone.0074990. eCollection 2013.


A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat.

Zambrano E, Bautista CJ, Deás M, Martínez-Samayoa PM, González-Zamorano M, Ledesma H, Morales J, Larrea F, Nathanielsz PW.

J Physiol. 2006 Feb 15;571(Pt 1):221-30. Epub 2005 Dec 8.


Maternal high-calorie diet is associated with altered hepatic microRNA expression and impaired metabolic health in offspring at weaning age.

Zheng J, Zhang Q, Mul JD, Yu M, Xu J, Qi C, Wang T, Xiao X.

Endocrine. 2016 Oct;54(1):70-80. Epub 2016 Apr 22.


Maternal cigarette smoke exposure contributes to glucose intolerance and decreased brain insulin action in mice offspring independent of maternal diet.

Chen H, Iglesias MA, Caruso V, Morris MJ.

PLoS One. 2011;6(11):e27260. doi: 10.1371/journal.pone.0027260. Epub 2011 Nov 4.


Maternal low-protein diet alters pancreatic islet mitochondrial function in a sex-specific manner in the adult rat.

Theys N, Bouckenooghe T, Ahn MT, Remacle C, Reusens B.

Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1516-25. doi: 10.1152/ajpregu.00280.2009. Epub 2009 Sep 16.


Prenatal exposure to diesel exhaust PM2.5 causes offspring β cell dysfunction in adulthood.

Chen M, Liang S, Qin X, Zhang L, Qiu L, Chen S, Hu Z, Xu Y, Wang W, Zhang Y, Cao Q, Ying Z.

Am J Physiol Endocrinol Metab. 2018 Jul 1;315(1):E72-E80. doi: 10.1152/ajpendo.00336.2017. Epub 2017 Dec 26.


Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring.

Zhang Q, Sun X, Xiao X, Zheng J, Li M, Yu M, Ping F, Wang Z, Qi C, Wang T, Wang X.

PLoS One. 2017 Jan 10;12(1):e0169889. doi: 10.1371/journal.pone.0169889. eCollection 2017.


Maternal vitamin D-restricted diet has consequences in the formation of pancreatic islet/insulin-signaling in the adult offspring of mice.

Maia-Ceciliano TC, Barreto-Vianna AR, Barbosa-da-Silva S, Aguila MB, Faria TS, Mandarim-de-Lacerda CA.

Endocrine. 2016 Oct;54(1):60-69. Epub 2016 May 3.


Maternal Exercise Improves Glucose Tolerance in Female Offspring.

Stanford KI, Takahashi H, So K, Alves-Wagner AB, Prince NB, Lehnig AC, Getchell KM, Lee MY, Hirshman MF, Goodyear LJ.

Diabetes. 2017 Aug;66(8):2124-2136. doi: 10.2337/db17-0098. Epub 2017 Jun 1.

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