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Items: 1 to 20 of 248

1.

Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.

Tang W, Strachan RT, Lefkowitz RJ, Rockman HA.

J Biol Chem. 2014 Oct 10;289(41):28271-83. doi: 10.1074/jbc.M114.585067. Epub 2014 Aug 28.

2.

Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling.

Wang J, Hanada K, Gareri C, Rockman HA.

J Cell Biochem. 2018 Apr;119(4):3586-3597. doi: 10.1002/jcb.26552. Epub 2018 Jan 4.

3.

Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs.

Zimmerman B, Beautrait A, Aguila B, Charles R, Escher E, Claing A, Bouvier M, Laporte SA.

Sci Signal. 2012 Apr 24;5(221):ra33. doi: 10.1126/scisignal.2002522.

4.

Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanisms.

Bonde MM, Hansen JT, Sanni SJ, Haunsø S, Gammeltoft S, Lyngsø C, Hansen JL.

PLoS One. 2010 Nov 30;5(11):e14135. doi: 10.1371/journal.pone.0014135.

5.

Angiotensin type 1A receptor regulates β-arrestin binding of the β2-adrenergic receptor via heterodimerization.

Tóth AD, Gyombolai P, Szalai B, Várnai P, Turu G, Hunyady L.

Mol Cell Endocrinol. 2017 Feb 15;442:113-124. doi: 10.1016/j.mce.2016.11.027. Epub 2016 Nov 28.

PMID:
27908837
6.

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

Shukla AK, Violin JD, Whalen EJ, Gesty-Palmer D, Shenoy SK, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9988-93. doi: 10.1073/pnas.0804246105. Epub 2008 Jul 11.

7.

Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors.

Sleno R, Devost D, Pétrin D, Zhang A, Bourque K, Shinjo Y, Aoki J, Inoue A, Hébert TE.

J Biol Chem. 2017 Jul 21;292(29):12139-12152. doi: 10.1074/jbc.M117.793877. Epub 2017 Jun 5.

9.

Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR).

Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Rojas Bie Thomsen A, Zhu X, Kleist A, Costa T, Lefkowitz RJ.

J Biol Chem. 2014 May 16;289(20):14211-24. doi: 10.1074/jbc.M114.548131. Epub 2014 Mar 25.

10.

Biased agonism of the angiotensin II type 1 receptor.

Godin CM, Ferguson SS.

Mini Rev Med Chem. 2012 Aug;12(9):812-6. Review.

PMID:
22681254
11.

Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.

Violin JD, DeWire SM, Yamashita D, Rominger DH, Nguyen L, Schiller K, Whalen EJ, Gowen M, Lark MW.

J Pharmacol Exp Ther. 2010 Dec;335(3):572-9. doi: 10.1124/jpet.110.173005. Epub 2010 Aug 26.

PMID:
20801892
12.

β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.

Kim KS, Abraham D, Williams B, Violin JD, Mao L, Rockman HA.

Am J Physiol Heart Circ Physiol. 2012 Oct 15;303(8):H1001-10. doi: 10.1152/ajpheart.00475.2012. Epub 2012 Aug 10.

13.

Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations.

Cabana J, Holleran B, Leduc R, Escher E, Guillemette G, Lavigne P.

J Biol Chem. 2015 Jun 19;290(25):15835-54. doi: 10.1074/jbc.M114.627356. Epub 2015 May 1.

14.

Biased Agonism of the Angiotensin II Type I Receptor.

Ikeda Y, Kumagai H, Motozawa Y, Suzuki J, Komuro I.

Int Heart J. 2015;56(5):485-8. doi: 10.1536/ihj.15-256. Epub 2015 Jul 14. Review.

15.

Investigation of the fate of type I angiotensin receptor after biased activation.

Szakadáti G, Tóth AD, Oláh I, Erdélyi LS, Balla T, Várnai P, Hunyady L, Balla A.

Mol Pharmacol. 2015 Jun;87(6):972-81. doi: 10.1124/mol.114.097030. Epub 2015 Mar 24.

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18.

Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms.

St-Pierre D, Cabana J, Holleran BJ, Besserer-Offroy É, Escher E, Guillemette G, Lavigne P, Leduc R.

Biochem Pharmacol. 2018 Aug;154:104-117. doi: 10.1016/j.bcp.2018.04.021. Epub 2018 Apr 20.

PMID:
29684376
20.

Single-molecule force spectroscopy study of interactions between angiotensin II type 1 receptor and different biased ligands in living cells.

Li W, Xu J, Kou X, Zhao R, Zhou W, Fang X.

Anal Bioanal Chem. 2018 May;410(14):3275-3284. doi: 10.1007/s00216-018-0956-3. Epub 2018 Feb 28.

PMID:
29492619

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