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Items: 1 to 20 of 129

1.

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells.

Lee Y, Berglund ED, Yu X, Wang MY, Evans MR, Scherer PE, Holland WL, Charron MJ, Roth MG, Unger RH.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13217-22. doi: 10.1073/pnas.1409638111. Epub 2014 Aug 25.

2.

Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor-deficient mice.

Omar BA, Andersen B, Hald J, Raun K, Nishimura E, Ahrén B.

Diabetes. 2014 Jan;63(1):101-10. doi: 10.2337/db13-0710. Epub 2013 Sep 23.

3.

Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic alpha and beta cells in two models of alpha cell hyperplasia.

Kedees MH, Grigoryan M, Guz Y, Teitelman G.

Mol Cell Endocrinol. 2009 Nov 13;311(1-2):69-76. doi: 10.1016/j.mce.2009.07.024. Epub 2009 Jul 30.

4.

Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia.

Conarello SL, Jiang G, Mu J, Li Z, Woods J, Zycband E, Ronan J, Liu F, Roy RS, Zhu L, Charron MJ, Zhang BB.

Diabetologia. 2007 Jan;50(1):142-50. Epub 2006 Nov 28.

PMID:
17131145
5.

Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass.

Gelling RW, Vuguin PM, Du XQ, Cui L, Rømer J, Pederson RA, Leiser M, Sørensen H, Holst JJ, Fledelius C, Johansen PB, Fleischer N, McIntosh CH, Nishimura E, Charron MJ.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E695-707. doi: 10.1152/ajpendo.00082.2009. Epub 2009 Jul 14.

6.

Transgenic expression of insulin-response element binding protein-1 in beta-cells reproduces type 2 diabetes.

Villafuerte BC, Barati MT, Song Y, Moore JP, Epstein PN, Portillo J.

Endocrinology. 2009 Jun;150(6):2611-7. doi: 10.1210/en.2008-1294. Epub 2009 Feb 12.

7.

Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia.

Gu W, Yan H, Winters KA, Komorowski R, Vonderfecht S, Atangan L, Sivits G, Hill D, Yang J, Bi V, Shen Y, Hu S, Boone T, Lindberg RA, Véniant MM.

J Pharmacol Exp Ther. 2009 Dec;331(3):871-81. doi: 10.1124/jpet.109.157685. Epub 2009 Aug 31.

8.

Human monoclonal antibodies against glucagon receptor improve glucose homeostasis by suppression of hepatic glucose output in diet-induced obese mice.

Kim WD, Lee YH, Kim MH, Jung SY, Son WC, Yoon SJ, Lee BW.

PLoS One. 2012;7(12):e50954. doi: 10.1371/journal.pone.0050954. Epub 2012 Dec 3.

9.

Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice.

Pocai A, Carrington PE, Adams JR, Wright M, Eiermann G, Zhu L, Du X, Petrov A, Lassman ME, Jiang G, Liu F, Miller C, Tota LM, Zhou G, Zhang X, Sountis MM, Santoprete A, Capito' E, Chicchi GG, Thornberry N, Bianchi E, Pessi A, Marsh DJ, SinhaRoy R.

Diabetes. 2009 Oct;58(10):2258-66. doi: 10.2337/db09-0278. Epub 2009 Jul 14.

10.

Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor.

Longuet C, Robledo AM, Dean ED, Dai C, Ali S, McGuinness I, de Chavez V, Vuguin PM, Charron MJ, Powers AC, Drucker DJ.

Diabetes. 2013 Apr;62(4):1196-205. doi: 10.2337/db11-1605. Epub 2012 Nov 16.

11.

Metabolic manifestations of insulin deficiency do not occur without glucagon action.

Lee Y, Berglund ED, Wang MY, Fu X, Yu X, Charron MJ, Burgess SC, Unger RH.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14972-6. doi: 10.1073/pnas.1205983109. Epub 2012 Aug 13.

12.

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice.

Lee Y, Wang MY, Du XQ, Charron MJ, Unger RH.

Diabetes. 2011 Feb;60(2):391-7. doi: 10.2337/db10-0426.

13.

Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis.

Kumar DP, Asgharpour A, Mirshahi F, Park SH, Liu S, Imai Y, Nadler JL, Grider JR, Murthy KS, Sanyal AJ.

J Biol Chem. 2016 Mar 25;291(13):6626-40. doi: 10.1074/jbc.M115.699504. Epub 2016 Jan 12.

14.

Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.

Thorel F, Damond N, Chera S, Wiederkehr A, Thorens B, Meda P, Wollheim CB, Herrera PL.

Diabetes. 2011 Nov;60(11):2872-82. doi: 10.2337/db11-0876. Epub 2011 Sep 16.

15.

Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice.

Mu J, Jiang G, Brady E, Dallas-Yang Q, Liu F, Woods J, Zycband E, Wright M, Li Z, Lu K, Zhu L, Shen X, Sinharoy R, Candelore ML, Qureshi SA, Shen DM, Zhang F, Parmee ER, Zhang BB.

Diabetologia. 2011 Sep;54(9):2381-91. doi: 10.1007/s00125-011-2217-2. Epub 2011 Jun 22.

PMID:
21695571
16.

Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.

Moralejo DH, Hansen CT, Treuting P, Hessner MJ, Fuller JM, Van Yserloo B, Jensen R, Osborne W, Kwitek AE, Lernmark A.

Physiol Genomics. 2010 Mar 3;41(1):9-20. doi: 10.1152/physiolgenomics.00186.2009. Epub 2009 Dec 8.

17.

Insulin signaling in alpha cells modulates glucagon secretion in vivo.

Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN.

Cell Metab. 2009 Apr;9(4):350-61. doi: 10.1016/j.cmet.2009.02.007.

18.

Effect of chronic p,p'-dichlorodiphenyldichloroethylene (DDE) exposure on high fat diet-induced alterations in glucose and lipid metabolism in male C57BL/6H mice.

Howell GE 3rd, Mulligan C, Meek E, Chambers JE.

Toxicology. 2015 Feb 3;328:112-22. doi: 10.1016/j.tox.2014.12.017. Epub 2014 Dec 23.

PMID:
25541407
19.

Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents.

Day JW, Gelfanov V, Smiley D, Carrington PE, Eiermann G, Chicchi G, Erion MD, Gidda J, Thornberry NA, Tschöp MH, Marsh DJ, SinhaRoy R, DiMarchi R, Pocai A.

Biopolymers. 2012;98(5):443-50. doi: 10.1002/bip.22072.

PMID:
23203689
20.

Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function.

Sørensen H, Winzell MS, Brand CL, Fosgerau K, Gelling RW, Nishimura E, Ahren B.

Diabetes. 2006 Dec;55(12):3463-9.

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