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Items: 1 to 20 of 128

1.

Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.

Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV Jr, Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ.

J Biol Chem. 2014 Oct 24;289(43):29881-91. doi: 10.1074/jbc.M114.601864. Epub 2014 Aug 25.

2.

DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle.

Liu L, Yu S, Khan RS, Ables GP, Bharadwaj KG, Hu Y, Huggins LA, Eriksson JW, Buckett LK, Turnbull AV, Ginsberg HN, Blaner WS, Huang LS, Goldberg IJ.

J Lipid Res. 2011 Apr;52(4):732-44. doi: 10.1194/jlr.M011395. Epub 2011 Jan 3.

3.

DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity.

Liu L, Shi X, Bharadwaj KG, Ikeda S, Yamashita H, Yagyu H, Schaffer JE, Yu YH, Goldberg IJ.

J Biol Chem. 2009 Dec 25;284(52):36312-23. doi: 10.1074/jbc.M109.049817. Epub 2009 Sep 24.

4.

Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice.

Liu L, Yu S, Khan RS, Homma S, Schulze PC, Blaner WS, Yin Y, Goldberg IJ.

J Lipid Res. 2012 Aug;53(8):1482-92. doi: 10.1194/jlr.M024208. Epub 2012 May 24.

5.

Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse.

Glenn DJ, Cardema MC, Gardner DG.

J Steroid Biochem Mol Biol. 2016 Nov;164:292-298. doi: 10.1016/j.jsbmb.2015.09.034. Epub 2015 Sep 30. Review.

PMID:
26429397
6.

A murine model of isolated cardiac steatosis leads to cardiomyopathy.

Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG.

Hypertension. 2011 Feb;57(2):216-22. doi: 10.1161/HYPERTENSIONAHA.110.160655. Epub 2011 Jan 10.

7.

Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases.

Cao J, Zhou Y, Peng H, Huang X, Stahler S, Suri V, Qadri A, Gareski T, Jones J, Hahm S, Perreault M, McKew J, Shi M, Xu X, Tobin JF, Gimeno RE.

J Biol Chem. 2011 Dec 2;286(48):41838-51. doi: 10.1074/jbc.M111.245456. Epub 2011 Oct 11.

8.

Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload.

Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Colucci WS, Miller EJ.

J Mol Cell Cardiol. 2015 Feb;79:275-83. doi: 10.1016/j.yjmcc.2014.12.001. Epub 2014 Dec 9.

9.

Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans.

Maciejewski BS, LaPerle JL, Chen D, Ghosh A, Zavadoski WJ, McDonald TS, Manion TB, Mather D, Patterson TA, Hanna M, Watkins S, Gibbs EM, Calle RA, Steppan CM.

Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1;304(11):G958-69. doi: 10.1152/ajpgi.00384.2012. Epub 2013 Apr 4.

10.

Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes.

Yu YH, Zhang Y, Oelkers P, Sturley SL, Rader DJ, Ginsberg HN.

J Biol Chem. 2002 Dec 27;277(52):50876-84. Epub 2002 Oct 28.

11.

Intestine-targeted DGAT1 inhibition improves obesity and insulin resistance without skin aberrations in mice.

Tsuda N, Kumadaki S, Higashi C, Ozawa M, Shinozaki M, Kato Y, Hoshida K, Kikuchi S, Nakano Y, Ogawa Y, Furusako S.

PLoS One. 2014 Nov 18;9(11):e112027. doi: 10.1371/journal.pone.0112027. eCollection 2014.

12.

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.

Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI.

J Biol Chem. 2007 Aug 3;282(31):22678-88. Epub 2007 May 27.

13.

Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1.

Liu L, Shi X, Choi CS, Shulman GI, Klaus K, Nair KS, Schwartz GJ, Zhang Y, Goldberg IJ, Yu YH.

Diabetes. 2009 Nov;58(11):2516-24. doi: 10.2337/db08-1096. Epub 2009 Aug 12.

14.

Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance.

Liu L, Zhang Y, Chen N, Shi X, Tsang B, Yu YH.

J Clin Invest. 2007 Jun;117(6):1679-89. Epub 2007 May 17.

15.

Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying.

Ables GP, Yang KJ, Vogel S, Hernandez-Ono A, Yu S, Yuen JJ, Birtles S, Buckett LK, Turnbull AV, Goldberg IJ, Blaner WS, Huang LS, Ginsberg HN.

J Lipid Res. 2012 Nov;53(11):2364-79. doi: 10.1194/jlr.M029041. Epub 2012 Aug 21.

16.

Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure.

Chokshi A, Drosatos K, Cheema FH, Ji R, Khawaja T, Yu S, Kato T, Khan R, Takayama H, Knöll R, Milting H, Chung CS, Jorde U, Naka Y, Mancini DM, Goldberg IJ, Schulze PC.

Circulation. 2012 Jun 12;125(23):2844-53. doi: 10.1161/CIRCULATIONAHA.111.060889. Epub 2012 May 14.

17.

PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation.

Son NH, Yu S, Tuinei J, Arai K, Hamai H, Homma S, Shulman GI, Abel ED, Goldberg IJ.

J Clin Invest. 2010 Oct;120(10):3443-54. doi: 10.1172/JCI40905. Epub 2010 Sep 13. Erratum in: J Clin Invest. 2010 Dec 1;120(12):4583.

18.

Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.

Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z.

Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2096-108. doi: 10.1152/ajpheart.00452.2009. Epub 2009 Oct 2.

19.

Enhancing Cardiac Triacylglycerol Metabolism Improves Recovery From Ischemic Stress.

Kolwicz SC Jr, Liu L, Goldberg IJ, Tian R.

Diabetes. 2015 Aug;64(8):2817-27. doi: 10.2337/db14-1943. Epub 2015 Apr 9.

20.

Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.

Niizeki T, Takeishi Y, Kitahara T, Arimoto T, Koyama Y, Goto K, Mende U, Kubota I.

Circ J. 2008 Feb;72(2):309-17.

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