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Items: 1 to 20 of 352

1.

Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.

Vikram A, Kim YR, Kumar S, Naqvi A, Hoffman TA, Kumar A, Miller FJ Jr, Kim CS, Irani K.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2301-9. doi: 10.1161/ATVBAHA.114.304338. Epub 2014 Aug 21.

2.

TNFα signals via p66(Shc) to induce E-Selectin, promote leukocyte transmigration and enhance permeability in human endothelial cells.

Laviola L, Orlando MR, Incalza MA, Caccioppoli C, Melchiorre M, Leonardini A, Cignarelli A, Tortosa F, Labarbuta R, Martemucci S, Pacelli C, Cocco T, Perrini S, Natalicchio A, Giorgino F.

PLoS One. 2013 Dec 2;8(12):e81930. doi: 10.1371/journal.pone.0081930. eCollection 2013.

3.

The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.

Natalicchio A, Tortosa F, Labarbuta R, Biondi G, Marrano N, Carchia E, Leonardini A, Cignarelli A, Bugliani M, Marchetti P, Fadini GP, Giorgio M, Avogaro A, Perrini S, Laviola L, Giorgino F.

Diabetologia. 2015 Jun;58(6):1260-71. doi: 10.1007/s00125-015-3563-2. Epub 2015 Mar 26. Erratum in: Diabetologia. 2015 Nov;58(11):2682.

PMID:
25810038
4.

Adaptor protein p66(Shc) mediates hypertension-associated, cyclic stretch-dependent, endothelial damage.

Spescha RD, Glanzmann M, Simic B, Witassek F, Keller S, Akhmedov A, Tanner FC, Lüscher TF, Camici GG.

Hypertension. 2014 Aug;64(2):347-53. doi: 10.1161/HYPERTENSIONAHA.113.02129. Epub 2014 May 19.

5.

P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.

Li Q, Kim YR, Vikram A, Kumar S, Kassan M, Gabani M, Lee SK, Jacobs JS, Irani K.

Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2394-2403. Epub 2016 Oct 27.

6.

Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc.

Kim CS, Kim YR, Naqvi A, Kumar S, Hoffman TA, Jung SB, Kumar A, Jeon BH, McNamara DM, Irani K.

Cardiovasc Res. 2011 Dec 1;92(3):466-75. doi: 10.1093/cvr/cvr250. Epub 2011 Sep 20.

7.

Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells.

Shi Y, Cosentino F, Camici GG, Akhmedov A, Vanhoutte PM, Tanner FC, Lüscher TF.

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2090-7. doi: 10.1161/ATVBAHA.111.229260. Epub 2011 Aug 4.

PMID:
21817106
8.

Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

Camici GG, Schiavoni M, Francia P, Bachschmid M, Martin-Padura I, Hersberger M, Tanner FC, Pelicci P, Volpe M, Anversa P, Lüscher TF, Cosentino F.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5217-22. Epub 2007 Mar 14.

9.

Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis.

Jiang L, Yin M, Wei X, Liu J, Wang X, Niu C, Kang X, Xu J, Zhou Z, Sun S, Wang X, Zheng X, Duan S, Yao K, Qian R, Sun N, Chen A, Wang R, Zhang J, Chen S, Meng D.

Circ Res. 2015 Jul 31;117(4):364-375. doi: 10.1161/CIRCRESAHA.115.306829. Epub 2015 Jun 29. Erratum in: Circ Res. 2015 Oct 9;117(9):e79.

10.

p66(Shc)-induced redox changes drive endothelial insulin resistance.

Paneni F, Costantino S, Cosentino F.

Atherosclerosis. 2014 Oct;236(2):426-9. doi: 10.1016/j.atherosclerosis.2014.07.027. Epub 2014 Aug 5.

PMID:
25150941
11.

p66Shc-generated oxidative signal promotes fat accumulation.

Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, Pelicci PG, Giorgio M.

J Biol Chem. 2008 Dec 5;283(49):34283-93. doi: 10.1074/jbc.M804362200. Epub 2008 Oct 6.

12.

CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.

Nagar H, Jung SB, Kwon SK, Park JB, Shong M, Song HJ, Jeon BH, Irani K, Kim CS.

PLoS One. 2014 Jun 6;9(6):e98670. doi: 10.1371/journal.pone.0098670. eCollection 2014.

13.

Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts.

Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC.

J Biol Chem. 2011 Dec 30;286(52):44326-35. doi: 10.1074/jbc.M111.283481. Epub 2011 Oct 26.

14.

Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.

Almeida M, Han L, Ambrogini E, Bartell SM, Manolagas SC.

Mol Endocrinol. 2010 Oct;24(10):2030-7. doi: 10.1210/me.2010-0189. Epub 2010 Aug 4.

15.

D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc.

Sakao K, Singh SV.

J Cell Biochem. 2012 Feb;113(2):599-610. doi: 10.1002/jcb.23386.

16.

Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes.

Paneni F, Mocharla P, Akhmedov A, Costantino S, Osto E, Volpe M, Lüscher TF, Cosentino F.

Circ Res. 2012 Jul 20;111(3):278-89. doi: 10.1161/CIRCRESAHA.112.266593. Epub 2012 Jun 12.

PMID:
22693349
17.
18.

Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke.

Spescha RD, Klohs J, Semerano A, Giacalone G, Derungs RS, Reiner MF, Rodriguez Gutierrez D, Mendez-Carmona N, Glanzmann M, Savarese G, Kränkel N, Akhmedov A, Keller S, Mocharla P, Kaufmann MR, Wenger RH, Vogel J, Kulic L, Nitsch RM, Beer JH, Peruzzotti-Jametti L, Sessa M, Lüscher TF, Camici GG.

Eur Heart J. 2015 Jul 1;36(25):1590-600. doi: 10.1093/eurheartj/ehv140. Epub 2015 Apr 22.

19.

p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice.

Martin-Padura I, de Nigris F, Migliaccio E, Mansueto G, Minardi S, Rienzo M, Lerman LO, Stendardo M, Giorgio M, De Rosa G, Pelicci PG, Napoli C.

Endothelium. 2008 Sep-Oct;15(5-6):276-87. doi: 10.1080/10623320802487791.

PMID:
19065319
20.

Knockdown of p66Shc by siRNA injection rescues arsenite-induced developmental retardation in mouse preimplantation embryos.

Ren K, Li X, Yan J, Huang G, Zhou S, Yang B, Ma X, Lu C.

Reprod Toxicol. 2014 Jan;43:8-18. doi: 10.1016/j.reprotox.2013.10.008. Epub 2013 Oct 31.

PMID:
24184494

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