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Items: 1 to 20 of 148

1.

Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging.

Gu WG, Zhang X, Ip DT, Yang LM, Zheng YT, Wan DC.

FEBS Lett. 2014 Sep 17;588(18):3461-8. doi: 10.1016/j.febslet.2014.08.004. Epub 2014 Aug 13.

2.

1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor.

Gu WG, Ip DT, Liu SJ, Chan JH, Wang Y, Zhang X, Zheng YT, Wan DC.

Chem Biol Interact. 2014 Apr 25;213:21-7. doi: 10.1016/j.cbi.2014.01.011. Epub 2014 Jan 28.

PMID:
24480521
3.

Inhibition of the interaction between HIV-1 integrase and its cofactor LEDGF/p75: a promising approach in anti-retroviral therapy.

De Luca L, Ferro S, Morreale F, Chimirri A.

Mini Rev Med Chem. 2011 Jul;11(8):714-27. Review.

PMID:
21651465
4.

New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays.

De Luca L, Morreale F, Christ F, Debyser Z, Ferro S, Gitto R.

Eur J Med Chem. 2013 Oct;68:405-11. doi: 10.1016/j.ejmech.2013.07.025. Epub 2013 Aug 9.

PMID:
23994868
5.

Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays.

Hu G, Li X, Zhang X, Li Y, Ma L, Yang LM, Liu G, Li W, Huang J, Shen X, Hu L, Zheng YT, Tang Y.

J Med Chem. 2012 Nov 26;55(22):10108-17. doi: 10.1021/jm301226a. Epub 2012 Oct 22.

PMID:
23046280
6.

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

De Luca L, Barreca ML, Ferro S, Christ F, Iraci N, Gitto R, Monforte AM, Debyser Z, Chimirri A.

ChemMedChem. 2009 Aug;4(8):1311-6. doi: 10.1002/cmdc.200900070.

PMID:
19565598
7.

D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.

Du L, Zhao Y, Chen J, Yang L, Zheng Y, Tang Y, Shen X, Jiang H.

Biochem Biophys Res Commun. 2008 Oct 10;375(1):139-44. doi: 10.1016/j.bbrc.2008.07.139. Epub 2008 Aug 6.

PMID:
18691555
8.

Virtual-screening targeting Human Immunodeficiency Virus type 1 integrase-lens epithelium-derived growth factor/p75 interaction for drug development.

Gu WG, Liu BN, Yuan JF.

J Drug Target. 2015 Feb;23(2):134-9. doi: 10.3109/1061186X.2014.959020. Epub 2014 Sep 18. Review.

PMID:
25230778
9.

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.

Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E.

J Biol Chem. 2016 Nov 4;291(45):23569-23577. Epub 2016 Sep 19.

10.

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy.

Christ F, Debyser Z.

Virology. 2013 Jan 5;435(1):102-9. doi: 10.1016/j.virol.2012.09.033. Review. Erratum in: Virology. 2013 Mar 30;438(1):50.

11.

Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization.

Christ F, Shaw S, Demeulemeester J, Desimmie BA, Marchand A, Butler S, Smets W, Chaltin P, Westby M, Debyser Z, Pickford C.

Antimicrob Agents Chemother. 2012 Aug;56(8):4365-74. doi: 10.1128/AAC.00717-12. Epub 2012 Jun 4.

12.

Molecular modeling study on the allosteric inhibition mechanism of HIV-1 integrase by LEDGF/p75 binding site inhibitors.

Xue W, Liu H, Yao X.

PLoS One. 2014 Mar 5;9(3):e90799. doi: 10.1371/journal.pone.0090799. eCollection 2014.

13.

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.

Le Rouzic E, Bonnard D, Chasset S, Bruneau JM, Chevreuil F, Le Strat F, Nguyen J, Beauvoir R, Amadori C, Brias J, Vomscheid S, Eiler S, Lévy N, Delelis O, Deprez E, Saïb A, Zamborlini A, Emiliani S, Ruff M, Ledoussal B, Moreau F, Benarous R.

Retrovirology. 2013 Nov 21;10:144. doi: 10.1186/1742-4690-10-144.

14.

Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein.

Hayouka Z, Hurevich M, Levin A, Benyamini H, Iosub A, Maes M, Shalev DE, Loyter A, Gilon C, Friedler A.

Bioorg Med Chem. 2010 Dec 1;18(23):8388-95. doi: 10.1016/j.bmc.2010.09.046. Epub 2010 Oct 1.

PMID:
20974536
15.

Blocking the interaction between HIV-1 integrase and human LEDGF/p75: mutational studies, virtual screening and molecular dynamics simulations.

Reddy KK, Singh P, Singh SK.

Mol Biosyst. 2014 Mar 4;10(3):526-36. doi: 10.1039/c3mb70418a. Epub 2014 Jan 6.

PMID:
24389668
16.

Wikstroelide M potently inhibits HIV replication by targeting reverse transcriptase and integrase nuclear translocation.

Zhang X, Huang SZ, Gu WG, Yang LM, Chen H, Zheng CB, Zhao YX, Wan DC, Zheng YT.

Chin J Nat Med. 2014 Mar;12(3):186-93. doi: 10.1016/S1875-5364(14)60031-5.

PMID:
24702804
17.

Traditional Chinese medicine application in HIV: an in silico study.

Huang HJ, Jian YR, Chen CY.

J Biomol Struct Dyn. 2014;32(1):1-12. doi: 10.1080/07391102.2012.745168. Epub 2012 Dec 20.

PMID:
23252879
18.

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.

Serrao E, Xu ZL, Debnath B, Christ F, Debyser Z, Long YQ, Neamati N.

Bioorg Med Chem. 2013 Oct 1;21(19):5963-72. doi: 10.1016/j.bmc.2013.07.047. Epub 2013 Aug 2.

19.

The evaluation of statins as potential inhibitors of the LEDGF/p75-HIV-1 integrase interaction.

Harrison AT, Kriel FH, Papathanasopoulos MA, Mosebi S, Abrahams S, Hewer R.

Chem Biol Drug Des. 2015 Mar;85(3):290-5. doi: 10.1111/cbdd.12384. Epub 2014 Jul 12.

PMID:
24954548
20.

Discovery of HIV-1 integrase inhibitors: pharmacophore mapping, virtual screening, molecular docking, synthesis, and biological evaluation.

Bhatt H, Patel P, Pannecouque C.

Chem Biol Drug Des. 2014 Feb;83(2):154-66. doi: 10.1111/cbdd.12207. Epub 2013 Oct 4.

PMID:
23957390

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