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Items: 1 to 20 of 100

1.

Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.

Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK.

Cell Host Microbe. 2014 Aug 13;16(2):187-200. doi: 10.1016/j.chom.2014.07.008.

2.

VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.

Schwarz TM, Edwards MR, Diederichs A, Alinger JB, Leung DW, Amarasinghe GK, Basler CF.

J Virol. 2017 Jan 31;91(4). pii: e01715-16. doi: 10.1128/JVI.01715-16. Print 2017 Feb 15.

3.

Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.

Reid SP, Valmas C, Martinez O, Sanchez FM, Basler CF.

J Virol. 2007 Dec;81(24):13469-77. Epub 2007 Oct 10.

4.

The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin α1 and partially alters its nuclear import.

Shabman RS, Gulcicek EE, Stone KL, Basler CF.

J Infect Dis. 2011 Nov;204 Suppl 3:S904-10. doi: 10.1093/infdis/jir323.

5.

Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation.

Reid SP, Leung LW, Hartman AL, Martinez O, Shaw ML, Carbonnelle C, Volchkov VE, Nichol ST, Basler CF.

J Virol. 2006 Jun;80(11):5156-67.

6.

The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold.

Zhang AP, Bornholdt ZA, Liu T, Abelson DM, Lee DE, Li S, Woods VL Jr, Saphire EO.

PLoS Pathog. 2012 Feb;8(2):e1002550. doi: 10.1371/journal.ppat.1002550. Epub 2012 Feb 23. Erratum in: PLoS Pathog. 2013 Dec;9(12). doi:10.1371/annotation/360ddc68-0313-4eae-af24-043cc040c52d.

7.

Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling.

Mateo M, Reid SP, Leung LW, Basler CF, Volchkov VE.

J Virol. 2010 Jan;84(2):1169-75. doi: 10.1128/JVI.01372-09. Epub 2009 Nov 4.

8.

An all-atom molecular dynamics study of the anti-interferon signaling of Ebola virus: interaction mechanisms of EBOV VP24 binding to Karyopherin alpha5.

Ding JN, Zhang YJ, Zhong H, Ao CC, Li J, Han JG.

Mol Biosyst. 2017 May 2;13(5):1031-1045. doi: 10.1039/c7mb00136c.

PMID:
28418440
9.

Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5.

Nardozzi J, Wenta N, Yasuhara N, Vinkemeier U, Cingolani G.

J Mol Biol. 2010 Sep 10;402(1):83-100. doi: 10.1016/j.jmb.2010.07.013. Epub 2010 Jul 17.

10.

Evasion of interferon responses by Ebola and Marburg viruses.

Basler CF, Amarasinghe GK.

J Interferon Cytokine Res. 2009 Sep;29(9):511-20. doi: 10.1089/jir.2009.0076. Review.

11.

How a virus blocks a cellular emergency access lane to the nucleus, STAT!

Daugherty MD, Malik HS.

Cell Host Microbe. 2014 Aug 13;16(2):150-152. doi: 10.1016/j.chom.2014.07.013.

12.

Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5.

Song X, Lu LY, Passioura T, Suga H.

Org Biomol Chem. 2017 Jun 21;15(24):5155-5160. doi: 10.1039/c7ob00012j.

PMID:
28574091
13.

Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.

Frieman M, Yount B, Heise M, Kopecky-Bromberg SA, Palese P, Baric RS.

J Virol. 2007 Sep;81(18):9812-24. Epub 2007 Jun 27.

14.

Fold prediction of VP24 protein of Ebola and Marburg viruses using de novo fragment assembly.

Lee MS, Lebeda FJ, Olson MA.

J Struct Biol. 2009 Aug;167(2):136-44. doi: 10.1016/j.jsb.2009.05.001. Epub 2009 May 15.

PMID:
19447180
15.

Lloviu virus VP24 and VP35 proteins function as innate immune antagonists in human and bat cells.

Feagins AR, Basler CF.

Virology. 2015 Nov;485:145-52. doi: 10.1016/j.virol.2015.07.010. Epub 2015 Aug 6.

16.

Nuclear Respiratory Factor 2β (NRF-2β) recruits NRF-2α to the nucleus by binding to importin-α:β via an unusual monopartite-type nuclear localization signal.

Hayashi R, Takeuchi N, Ueda T.

J Mol Biol. 2013 Sep 23;425(18):3536-48. doi: 10.1016/j.jmb.2013.07.007. Epub 2013 Jul 13.

17.
18.

The COOH-terminal nuclear localization sequence of interferon gamma regulates STAT1 alpha nuclear translocation at an intracellular site.

Subramaniam PS, Larkin J 3rd, Mujtaba MG, Walter MR, Johnson HM.

J Cell Sci. 2000 Aug;113 ( Pt 15):2771-81.

19.

Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein.

Melen K, Fagerlund R, Franke J, Kohler M, Kinnunen L, Julkunen I.

J Biol Chem. 2003 Jul 25;278(30):28193-200. Epub 2003 May 9.

20.

Characterization of an unusual importin alpha binding motif in the borna disease virus p10 protein that directs nuclear import.

Wolff T, Unterstab G, Heins G, Richt JA, Kann M.

J Biol Chem. 2002 Apr 5;277(14):12151-7. Epub 2002 Jan 16.

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