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Items: 1 to 20 of 153

1.

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW.

J Biol Chem. 2014 Sep 26;289(39):27215-34. doi: 10.1074/jbc.M114.599712. Epub 2014 Aug 12. Erratum in: J Biol Chem. 2014 Dec 26;289(52):35858.

2.

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.

Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, Liedtke W, Jimenez-Vargas NN, Vanner SJ, Bunnett NW.

J Biol Chem. 2015 May 29;290(22):13875-87. doi: 10.1074/jbc.M115.642736. Epub 2015 Apr 15.

3.

Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.

Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW.

J Physiol. 2007 Feb 1;578(Pt 3):715-33. Epub 2006 Nov 23.

4.

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo.

Grace MS, Lieu T, Darby B, Abogadie FC, Veldhuis N, Bunnett NW, McIntyre P.

Br J Pharmacol. 2014 Aug;171(16):3881-94. doi: 10.1111/bph.12750.

5.

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.

Lieu T, Savage E, Zhao P, Edgington-Mitchell L, Barlow N, Bron R, Poole DP, McLean P, Lohman RJ, Fairlie DP, Bunnett NW.

Br J Pharmacol. 2016 Sep;173(18):2752-65. doi: 10.1111/bph.13554. Epub 2016 Aug 3.

6.

Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice.

Cattaruzza F, Lyo V, Jones E, Pham D, Hawkins J, Kirkwood K, Valdez-Morales E, Ibeakanma C, Vanner SJ, Bogyo M, Bunnett NW.

Gastroenterology. 2011 Nov;141(5):1864-74.e1-3. doi: 10.1053/j.gastro.2011.07.035. Epub 2011 Jul 28.

7.

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

Poole DP, Amadesi S, Veldhuis NA, Abogadie FC, Lieu T, Darby W, Liedtke W, Lew MJ, McIntyre P, Bunnett NW.

J Biol Chem. 2013 Feb 22;288(8):5790-802. doi: 10.1074/jbc.M112.438184. Epub 2013 Jan 3.

8.

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.

Sostegni S, Diakov A, McIntyre P, Bunnett N, Korbmacher C, Haerteis S.

Pflugers Arch. 2015 Apr;467(4):687-701. doi: 10.1007/s00424-014-1539-6. Epub 2014 Jun 8. Erratum in: Pflugers Arch. 2017 Jun;469(5-6):845-846.

PMID:
24906497
9.

Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.

Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, Davis JB, Mayer EA, Bunnett NW.

J Neurosci. 2004 May 5;24(18):4300-12.

10.

Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants.

Cattaruzza F, Amadesi S, Carlsson JF, Murphy JE, Lyo V, Kirkwood K, Cottrell GS, Bogyo M, Knecht W, Bunnett NW.

Br J Pharmacol. 2014 Aug;171(16):3814-26. doi: 10.1111/bph.12738.

11.

Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.

Amadesi S, Cottrell GS, Divino L, Chapman K, Grady EF, Bautista F, Karanjia R, Barajas-Lopez C, Vanner S, Vergnolle N, Bunnett NW.

J Physiol. 2006 Sep 1;575(Pt 2):555-71. Epub 2006 Jun 22.

12.

Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2.

Zhao P, Pattison LA, Jensen DD, Jimenez-Vargas NN, Latorre R, Lieu T, Jaramillo JO, Lopez-Lopez C, Poole DP, Vanner SJ, Schmidt BL, Bunnett NW.

J Biol Chem. 2019 Jul 5;294(27):10649-10662. doi: 10.1074/jbc.RA118.006935. Epub 2019 May 29.

PMID:
31142616
13.

The C-terminus of murine S100A9 protein inhibits hyperalgesia induced by the agonist peptide of protease-activated receptor 2 (PAR2).

Dale CS, Cenac N, Britto LR, Juliano MA, Juliano L, Vergnolle N, Giorgi R.

Br J Pharmacol. 2006 Oct;149(4):374-84. Epub 2006 Sep 11.

14.

Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2.

Huang ZJ, Li HC, Cowan AA, Liu S, Zhang YK, Song XJ.

Pain. 2012 Jul;153(7):1426-37. doi: 10.1016/j.pain.2012.03.025. Epub 2012 Apr 27.

PMID:
22541444
15.

Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2.

Amadesi S, Grant AD, Cottrell GS, Vaksman N, Poole DP, Rozengurt E, Bunnett NW.

J Comp Neurol. 2009 Sep 10;516(2):141-56. doi: 10.1002/cne.22104.

16.

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.

Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16.

17.

Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.

Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skåregärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW.

J Biol Chem. 2007 Sep 7;282(36):26089-100. Epub 2007 Jul 10.

18.

Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice.

Ceppa E, Cattaruzza F, Lyo V, Amadesi S, Pelayo JC, Poole DP, Vaksman N, Liedtke W, Cohen DM, Grady EF, Bunnett NW, Kirkwood KS.

Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G556-71. doi: 10.1152/ajpgi.00433.2009. Epub 2010 Jun 10.

19.

Cathepsin S signals via PAR2 and generates a novel tethered ligand receptor agonist.

Elmariah SB, Reddy VB, Lerner EA.

PLoS One. 2014 Jun 25;9(6):e99702. doi: 10.1371/journal.pone.0099702. eCollection 2014.

20.

Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain.

Dai Y, Wang S, Tominaga M, Yamamoto S, Fukuoka T, Higashi T, Kobayashi K, Obata K, Yamanaka H, Noguchi K.

J Clin Invest. 2007 Jul;117(7):1979-87. Erratum in: J Clin Invest. 2007 Oct;117(10):3140.

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