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Items: 1 to 20 of 114

1.

Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.

Ho GD, Tulshian D, Bercovici A, Tan Z, Hanisak J, Brumfield S, Matasi J, Heap CR, Earley WG, Courneya B, Herr RJ, Zhou X, Bridal T, Rindgen D, Sorota S, Yang SW.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4110-3. doi: 10.1016/j.bmcl.2014.07.060.

PMID:
25113934
2.

Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain.

Yang SW, Ho GD, Tulshian D, Bercovici A, Tan Z, Hanisak J, Brumfield S, Matasi J, Sun X, Sakwa SA, Herr RJ, Zhou X, Bridal T, Urban M, Vivian J, Rindgen D, Sorota S.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):4958-62. doi: 10.1016/j.bmcl.2014.09.038.

PMID:
25288187
3.

Phenethyl nicotinamides, a novel class of Na(V)1.7 channel blockers: structure and activity relationship.

Kers I, Macsari I, Csjernyik G, Nylöf M, Skogholm K, Sandberg L, Minidis A, Bueters T, Malmborg J, Eriksson AB, Lund PE, Venyike E, Luo L, Nyström JE, Besidski Y.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6108-15. doi: 10.1016/j.bmcl.2012.08.031.

PMID:
22939696
4.

The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7.

Sun S, Jia Q, Zenova AY, Chafeev M, Zhang Z, Lin S, Kwan R, Grimwood ME, Chowdhury S, Young C, Cohen CJ, Oballa RM.

Bioorg Med Chem Lett. 2014 Sep 15;24(18):4397-401. doi: 10.1016/j.bmcl.2014.08.017.

PMID:
25176194
5.

Ligand- and structure-based virtual screening for clathrodin-derived human voltage-gated sodium channel modulators.

Tomašić T, Hartzoulakis B, Zidar N, Chan F, Kirby RW, Madge DJ, Peigneur S, Tytgat J, Kikelj D.

J Chem Inf Model. 2013 Dec 23;53(12):3223-32. doi: 10.1021/ci400505e.

PMID:
24215100
6.

Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.

Frost JM, DeGoey DA, Shi L, Gum RJ, Fricano MM, Lundgaard GL, El-Kouhen OF, Hsieh GC, Neelands T, Matulenko MA, Daanen JF, Pai M, Ghoreishi-Haack N, Zhan C, Zhang XF, Kort ME.

J Med Chem. 2016 Apr 14;59(7):3373-91. doi: 10.1021/acs.jmedchem.6b00063.

PMID:
27015369
7.

Modulation of peripheral Na(+) channels and neuronal firing by n-butyl-p-aminobenzoate.

Thériault O, Poulin H, Sculptoreanu A, de Groat WC, O'Leary ME, Chahine M.

Eur J Pharmacol. 2014 Mar 15;727:158-66. doi: 10.1016/j.ejphar.2014.01.036.

PMID:
24486399
8.

N-Aryl azacycles as novel sodium channel blockers.

Lynch SM, Tafesse L, Carlin K, Ghatak P, Shao B, Abdelhamid H, Kyle DJ.

Bioorg Med Chem Lett. 2015 Jan 1;25(1):48-52. doi: 10.1016/j.bmcl.2014.11.023.

PMID:
25435147
9.

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain.

Chowdhury S, Chafeev M, Liu S, Sun J, Raina V, Chui R, Young W, Kwan R, Fu J, Cadieux JA.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3676-81. doi: 10.1016/j.bmcl.2011.04.088.

PMID:
21570288
10.

Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.

Kort ME, Drizin I, Gregg RJ, Scanio MJ, Shi L, Gross MF, Atkinson RN, Johnson MS, Pacofsky GJ, Thomas JB, Carroll WA, Krambis MJ, Liu D, Shieh CC, Zhang X, Hernandez G, Mikusa JP, Zhong C, Joshi S, Honore P, Roeloffs R, Marsh KC, Murray BP, Liu J, Werness S, Faltynek CR, Krafte DS, Jarvis MF, Chapman ML, Marron BE.

J Med Chem. 2008 Feb 14;51(3):407-16. doi: 10.1021/jm070637u.

PMID:
18176998
11.

Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.

Williams BS, Felix JP, Priest BT, Brochu RM, Dai K, Hoyt SB, London C, Tang YS, Duffy JL, Parsons WH, Kaczorowski GJ, Garcia ML.

Biochemistry. 2007 Dec 18;46(50):14693-703.

PMID:
18027973
12.

Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling.

Du Y, Days E, Romaine I, Abney KK, Kaufmann K, Sulikowski G, Stauffer S, Lindsley CW, Weaver CD.

ACS Chem Neurosci. 2015 Jun 17;6(6):871-8. doi: 10.1021/acschemneuro.5b00004.

PMID:
25879403
13.

Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers.

Kers I, Csjernyik G, Macsari I, Nylöf M, Sandberg L, Skogholm K, Bueters T, Eriksson AB, Oerther S, Lund PE, Venyike E, Nyström JE, Besidski Y.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5618-24. doi: 10.1016/j.bmcl.2012.06.105.

PMID:
22832315
14.

Future potential and status of selective sodium channel blockers for the treatment of pain.

Priest BT.

Curr Opin Drug Discov Devel. 2009 Sep;12(5):682-92. Review.

PMID:
19736626
15.
16.

Inhibitors of voltage-gated sodium channel Nav1.7: patent applications since 2010.

Sun S, Cohen CJ, Dehnhardt CM.

Pharm Pat Anal. 2014 Sep;3(5):509-21. doi: 10.4155/ppa.14.39. Review. Erratum in: Pharm Pat Anal. 2014;3(6):640.

PMID:
25374320
17.

Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain.

Drizin I, Gregg RJ, Scanio MJ, Shi L, Gross MF, Atkinson RN, Thomas JB, Johnson MS, Carroll WA, Marron BE, Chapman ML, Liu D, Krambis MJ, Shieh CC, Zhang X, Hernandez G, Gauvin DM, Mikusa JP, Zhu CZ, Joshi S, Honore P, Marsh KC, Roeloffs R, Werness S, Krafte DS, Jarvis MF, Faltynek CR, Kort ME.

Bioorg Med Chem. 2008 Jun 15;16(12):6379-86. doi: 10.1016/j.bmc.2008.05.003.

PMID:
18501613
18.
19.

3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.

Macsari I, Besidski Y, Csjernyik G, Nilsson LI, Sandberg L, Yngve U, Ahlin K, Bueters T, Eriksson AB, Lund PE, Venyike E, Oerther S, Hygge Blakeman K, Luo L, Arvidsson PI.

J Med Chem. 2012 Aug 9;55(15):6866-80. doi: 10.1021/jm300623u.

PMID:
22770500
20.

Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain.

Hoyt SB, London C, Gorin D, Wyvratt MJ, Fisher MH, Abbadie C, Felix JP, Garcia ML, Li X, Lyons KA, McGowan E, MacIntyre DE, Martin WJ, Priest BT, Ritter A, Smith MM, Warren VA, Williams BS, Kaczorowski GJ, Parsons WH.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4630-4.

PMID:
17588748
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