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Items: 1 to 20 of 120

1.

Lean Big Data integration in systems biology and systems pharmacology.

Ma'ayan A, Rouillard AD, Clark NR, Wang Z, Duan Q, Kou Y.

Trends Pharmacol Sci. 2014 Sep;35(9):450-60. doi: 10.1016/j.tips.2014.07.001. Epub 2014 Aug 7.

2.

Translational bioinformatics and systems biology approaches for personalized medicine.

Yan Q.

Methods Mol Biol. 2010;662:167-78. doi: 10.1007/978-1-60761-800-3_8.

PMID:
20824471
3.

Systems pharmacology to predict drug toxicity: integration across levels of biological organization.

Bai JP, Abernethy DR.

Annu Rev Pharmacol Toxicol. 2013;53:451-73. doi: 10.1146/annurev-pharmtox-011112-140248. Epub 2012 Nov 5. Review.

PMID:
23140241
4.

Systems pharmacology: network analysis to identify multiscale mechanisms of drug action.

Zhao S, Iyengar R.

Annu Rev Pharmacol Toxicol. 2012;52:505-21. doi: 10.1146/annurev-pharmtox-010611-134520. Review.

5.

Network medicine: finding the links to personalized therapy.

Chen JY, Piquette-Miller M, Smith BP.

Clin Pharmacol Ther. 2013 Dec;94(6):613-6. doi: 10.1038/clpt.2013.195.

PMID:
24241633
6.

Role of systems pharmacology in understanding drug adverse events.

Berger SI, Iyengar R.

Wiley Interdiscip Rev Syst Biol Med. 2011 Mar-Apr;3(2):129-35. doi: 10.1002/wsbm.114. Epub 2010 Aug 27. Review.

7.

Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases.

Li P, Chen J, Wang J, Zhou W, Wang X, Li B, Tao W, Wang W, Wang Y, Yang L.

J Ethnopharmacol. 2014;151(1):93-107. doi: 10.1016/j.jep.2013.07.001. Epub 2013 Jul 9.

PMID:
23850710
8.

Cognitive IT-systems for big data analysis in medicine.

Isakova J.

Int J Risk Saf Med. 2015;27 Suppl 1:S108-9. doi: 10.3233/JRS-150711.

PMID:
26639685
9.

Using quantitative systems pharmacology for novel drug discovery.

PĂ©rez-Nueno VI.

Expert Opin Drug Discov. 2015 Dec;10(12):1315-31. doi: 10.1517/17460441.2015.1082543. Epub 2015 Aug 25. Review.

PMID:
26328768
10.

Drug discovery in the age of systems biology: the rise of computational approaches for data integration.

Iskar M, Zeller G, Zhao XM, van Noort V, Bork P.

Curr Opin Biotechnol. 2012 Aug;23(4):609-16. doi: 10.1016/j.copbio.2011.11.010. Epub 2011 Dec 5. Review.

PMID:
22153034
11.

Harnessing Big Data for Systems Pharmacology.

Xie L, Draizen EJ, Bourne PE.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:245-262. doi: 10.1146/annurev-pharmtox-010716-104659. Epub 2016 Oct 13. Review.

13.

Network analyses in systems pharmacology.

Berger SI, Iyengar R.

Bioinformatics. 2009 Oct 1;25(19):2466-72. doi: 10.1093/bioinformatics/btp465. Epub 2009 Jul 30. Review.

14.

Genome-scale modeling of human metabolism - a systems biology approach.

Mardinoglu A, Gatto F, Nielsen J.

Biotechnol J. 2013 Sep;8(9):985-96. doi: 10.1002/biot.201200275. Epub 2013 Apr 24. Review.

PMID:
23613448
15.

Providing data science support for systems pharmacology and its implications to drug discovery.

Hart T, Xie L.

Expert Opin Drug Discov. 2016;11(3):241-56. doi: 10.1517/17460441.2016.1135126. Epub 2016 Jan 9. Review.

16.

Systems engineering meets quantitative systems pharmacology: from low-level targets to engaging the host defenses.

Androulakis IP.

Wiley Interdiscip Rev Syst Biol Med. 2015 May-Jun;7(3):101-12. doi: 10.1002/wsbm.1294. Epub 2015 Mar 16. Review.

PMID:
25778449
17.

Text-mining solutions for biomedical research: enabling integrative biology.

Rebholz-Schuhmann D, Oellrich A, Hoehndorf R.

Nat Rev Genet. 2012 Dec;13(12):829-39. doi: 10.1038/nrg3337. Epub 2012 Nov 14. Review.

PMID:
23150036
18.

Linking tissues to phenotypes using gene expression profiles.

Oellrich A; Sanger Mouse Genetics Project, Smedley D.

Database (Oxford). 2014 Mar 13;2014:bau017. doi: 10.1093/database/bau017. Print 2014.

19.

Drug-target networks for Tanshinone IIA identified by data mining.

Chen SJ.

Chin J Nat Med. 2015 Oct;13(10):751-9. doi: 10.1016/S1875-5364(15)30075-3.

PMID:
26481375
20.

Network-based drug discovery by integrating systems biology and computational technologies.

Leung EL, Cao ZW, Jiang ZH, Zhou H, Liu L.

Brief Bioinform. 2013 Jul;14(4):491-505. doi: 10.1093/bib/bbs043. Epub 2012 Aug 9.

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